Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: A combined haplotype analysis

European Journal of Gastroenterology and Hepatology

Volumn 22, Issue 10, 2010, Pages 1189-1195

  Kupcinskas, Limas ^a   Wex, Thomas ^b   Kupcinskas, Juozas ^a   Leja, Marcis ^c   Ivanauskas, Audrius ^a   Jonaitis, Laimas Virgilijus ^a   Janciauskas, Dainius ^a   Kiudelis, Gediminas ^a   Funka, Konrads ^c   Sudraba, Agnese ^c   Chiu, Han Mo ^d   Lin, Jaw Town ^d   Malfertheiner, Peter ^b  

^a KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY OF LATVIA   (Latvia)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

gastric atrophy; haplotype analysis; interleukin 1; intestinal metaplasia; polymorphisms

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA;

ADULT; AGED; ARTICLE; ASIAN; ATROPHIC GASTRITIS; CARCINOGENESIS; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; DYSPEPSIA; ENDOSCOPY; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STOMACH BIOPSY; STOMACH CANCER;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GASTRITIS, ATROPHIC; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PRECANCEROUS CONDITIONS; RISK FACTORS; STOMACH NEOPLASMS;

EID: 77957579887     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32833cf3d5     Document Type: Article

References (30)

1. Koivurova OP, Karhukorpi JM, Joensuu ET, Koistinen PO, Valtonen JM, Karttunen TJ, et al. IL1 RN2/2 genotype and simultaneous carriage of genotypes IL1RN 2/2 and IL1Beta-511 T/T associated with oesophagitis in Helicobacter pylori-negative patients. Scand J Gastroenterol 2003;38:1217-1222.
2. Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008;134:306-323.
3. Peek RM Jr, Crabtree JE. Helicobacter infection and gastric neoplasia. J Pathol 2006;208:233-248.
4. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-789.
5. Sipponen P. Gastric cancer: pathogenesis, risks, and prevention. J Gastroenterol 2002;37:39-44.
6. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000;404:398-402.
7. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, et al. Cytokine gene polymorphism in human disease: on-balance line databases. Genes Immun 1999;1:3-19.
8. Vamvakopoulos JE, Taylor CJ, Morris-Stiff GJ, Green C, Metcalfe S. The interleukin-1 receptor antagonist gene: a single-copy variant of the intron 2 variable number tandem repeat (VNTR) polymorphism. Eur J Immunogenet 2007;29:337-340.
9. Camargo MC, Mera R, Correa P, Peek RM Jr, Fontham ET, Goodman KJ, et al. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006;15:1674-1687.
10. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, et al. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001;121:823-829.
11. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002;94:1680-1687.
12. Kamangar F, Cheng C, Abnet CC, Rabkin CS. Interleukin-1b polymorphisms and gastric cancer risk-a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006;15:1920-1928. (Pubitemid 44664269)
13. Murphy G, Thornton J, McManus R, Swan N, Ryan B, Hughes DJ, et al. Association of gastric disease with polymorphisms in the inflammatoryrelated genes IL1B, IL1RN, IL10, TNF and TLR4. Eur J Gastroenterol Hepatol 2009;21:630-635.
14. Perri F, Piepoli A, Bonvicini C, Gentile A, Quitadamo M, Di Candia M, et al. Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. Cytokine 2005;30:293-302.
15. Persson C, Engstrand L, Nyrén O, Hansson LE, Enroth H, Ekström AM, Ye W. Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden. Scand J Gastroenterol 2009;44:339-345.
16. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003;125:364-371.
17. Furuta T, El-Omar EM, Xiao F, Shirai N, Takashima M, Sugimura H, et al. Interleukin 1b polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 2002;123:92-105.
18. Zabaleta J, Camargo MC, Piazuelo MB, Fontham E, Schneider BG, Sicinschi LA, et al. Association of interleukin-1b gene polymorphisms with precancerous gastric lesions in African-Americans and Caucasians. Am J Gastroenterol 2006;101:163-171.
19. Gao L, Weck MN, Nieters A, Brenner H. Association between a proinflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany. Eur J Cancer 2009;45:428-434.
20. Vincenzi B, Patti G, Galluzzo S, Pantano F, Venditti O, Santini D, et al. Interleukin1beta-511T gene (IL1beta) polymorphism is correlated with gastric cancer in the Caucasian population: results from a meta-analysis. Oncol Rep 2008;20:1213-1220.
21. Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006;15:519-529.
22. Rogus J, Beck JD, Offenbacher S, Huttner K, Iacoviello L, Latella MC, et al. IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet 2008;123:387-398.
23. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-1181.
24. Rad R, Dossumbekova A, Neu B, Lang R, Bauer S, Saur D, et al. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 2004;53:1082-1089.
25. Wex T, Leodolter A, Bornschein J, Kuester D, Kähne T, Kropf S, et al. Interleukin 1beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany. Anticancer Res 2010;30:505-511.
26. Wex T, Bornschein J, Malfertheiner P. Host polymorphisms of immune regulatory genes as risk factors for gastric cancer. Minerva Gastroenterol Dietol 2009;55:395-408.
27. Chen A, Li CN, Hsu PI, Lai KH, Tseng HH, Hsu PN, et al. Risks of interleukin-1 genetic polymorphisms and Helicobacter pylori infection in the development of gastric cancer. Aliment Pharmacol Ther 2004;20:203-211.
28. Lahner E, Corleto VD, D'Ambra G, Di Giulio E, Delle Fave G, Annibale B. Is interleukin-1 genotyping useful for the clinical management of patients with atrophic body gastritis? Aliment Pharmacol Ther 2008;27:355-365.
29. Lee KA. Functional haplotype frequencies of the interleukin-1B promoter in the Korean population. Genomics Inform 2008;6:29-31.
30. Peleteiro B, Lunet N, Carrilho C, Durães C, Machado JC, La Vecchia C, et al. Association between cytokine gene polymorphisms and gastric precancerous lesions: systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2010;19:762-776.