3α,23-Isopropylidenedioxyolean-12-en-27-oic acid, a triterpene isolated from Aceriphyllum rossii, induces apoptosis in human cervical cancer HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 9, 2010, Pages 1620-1626

  Won, So Jung ^a   Ki, Yo Sook ^a   Chung, Kyung Sook ^a   Choi, Jung Hye ^a   Bae, Ki Hwan ^b   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

3 ,23 isopropylidenedioxyolean 12 en 27 oic acid; Apoptosis; Caspase; Endoplasmic reticulum stress; HeLa cell; Mitochondrial dysfunction

Indexed keywords

3ALPHA,23 ISOPROPYLIDENEDIOXYOLEAN 12 EN 27 OIC ACID; 4',6 DIAMIDINO 2 PHENYLINDOLE; CALCIUM; CALPAIN 1; CASPASE 12; CASPASE 3 INHIBITOR; CASPASE 8 INHIBITOR; CASPASE 9 INHIBITOR; CYTOCHROME C; DNA FRAGMENT; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; TRITERPENE; UNCLASSIFIED DRUG;

ACERIPHYLLUM ROSSII; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG ISOLATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; SAXIFRAGACEAE; SIGNAL TRANSDUCTION; STAINING; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; MITOCHONDRIA; OLEANOLIC ACID; OXIDATIVE STRESS; PLANT EXTRACTS; SAXIFRAGACEAE; TRITERPENES;

EID: 77957579341     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1620     Document Type: Article

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