Why are we still using oxygen to resuscitate term infants?

Journal of Perinatology

Volumn 30, Issue SUPPL. 1, 2010, Pages

  Saugstad, O D ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

100 oxygen; 21 oxygen; newborn resuscitation; oxygen toxicity

Indexed keywords

OXYGEN;

ARTIFICIAL VENTILATION; CLINICAL TRIAL; CONFERENCE PAPER; DRUG RESPONSE; EXTREMELY LOW BIRTH WEIGHT; HEART ARREST; HUMAN; NEWBORN DEATH; NEWBORN HYPOXIA; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; NONHUMAN; OXYGEN THERAPY; PREMATURITY; RESUSCITATION; VERY LOW BIRTH WEIGHT;

HUMANS; INFANT, EXTREMELY LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; OXYGEN; OXYGEN INHALATION THERAPY; REPERFUSION INJURY; RESPIRATORY INSUFFICIENCY; RESUSCITATION;

EID: 77957550841     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2010.94     Document Type: Conference Paper

References (50)

1. Obladen M. History of neonatal resuscitation. Part 2: oxygen and other drugs. Neonatology 2009;95:91-96.
2. Klaus M, Meyer BP. Oxygen therapy for the newborn. Pediatr Clin North Am 1966;13:731-752.
3. Emergency Cardiac Care Committee Subcommittees of the American Heart Association. Guidelines for cardiopulmonary resuscitation and emergency cardiac care, IV: pediatric basic life support. J Am Med Assoc 1992;268:2276-2281.
4. 2 in a hyperbaric chamber by positive pressure ventilation, in the resuscitation of newborn rabbits. J Pediatr 1966;68:153-163.
5. Saugstad OD, Aasen AO. Plasma hypoxanthine concentrations in pigs. A prognostic aid in hypoxia Eur Surg Res 1980;12:123-129.
6. Granger DN, Rutili G, McCord JM. Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981;81:22-29.
7. Perez-de-Sa V, Cunha-Goncalves D, Nordh A, Hansson S, Larsson A, Ley D et al. High brain tissue oxygen tension during ventilation with 100% oxygen after fetal asphyxia in newborn sheep. Pediatr Res 2009;65:57-61.
8. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 1988;23:143-150.
9. Poulsen JP, Oyasaeter S, Saugstad OD. Hypoxanthine, xanthine, and uric acid in newborn pigs during hypoxemia followed by resuscitation with room air or 100% oxygen. Crit Care Med 1993;21:1058-1065.
10. Rootwelt T, Løberg EM, Moen A, Oyasaeter S, Saugstad OD. Hypoxemia and reoxygenation with 21 or 100% oxygen in newborn pigs: changes in blood pressure, base deficit, and hypoxanthine and brain morphology. Pediatr Res 1992;32:107-113.
11. Rootwelt T, Odden JP, Hall C, Ganes T, Saugstad OD. Cerebral blood flow and evoked potentials during reoxygenation with 21 or 100% O2 in newborn pigs. J Appl Physiol 1993;75:2054-2060.
12. Feet BA, Medbö S, Rootwelt T, Ganes T, Saugstad OD. Hypoxemic resuscitation in newborn piglets: recovery of somatosensory evoked potentials, hypoxanthine, and acid-base balance. Pediatr Res 1998;43:690-696.
13. Feet BA, Yu XQ, Rootwelt T, Oyasaeter S, Saugstad OD. Effects of hypoxemia and reoxygenation with 21 or 100% oxygen in newborn piglets: extracellular hypoxanthine in cerebral cortex and femoral muscle. Crit Care Med 1997;25:1384-1391.
14. Kutzsche S, Ilves P, Kirkeby OJ, Saugstad OD. Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100 or 21% oxygen in newborn piglets. Pediatr Res 2001;49:834-842.
15. Kutzsche S, Kirkeby OJ, Rise IR, Saugstad OD. Effects of hypoxia and reoxygenation with 21 and 100%-oxygen on cerebral nitric oxide concentration and microcirculation in newborn piglets. Biol Neonate 1999;76:153-167.
16. Medbø S, Yu XQ, Asberg A, Saugstad OD. Pulmonary hemodynamics and plasma endothelin-1 during hypoxemia and reoxygenation with room air or 100% oxygen in a piglet model. Pediatr Res 1998;44:843-849.
17. Ramji S, Ahuja S, Thirupuram S, Rootwelt T, Rooth G, Saugstad OD. Resuscitation of asphyxic newborn infants with room air or 100% oxygen. Pediatr Res 1993;34:809-812.
18. Saugstad OD, Rootwelt T, Aalen O. Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study. Pediatrics 1998;102: e1.
19. Saugstad OD, Ramji S, Irani SF, El-Meneza S, Hernandez EA, Vento M et al. Resuscitation of newborn infants with 21 or 100% oxygen: follow-up at 18 to 24 months. Pediatrics 2003;112:296-300.
20. Munkeby BH, Børke WB, Bjørnland K, Sikkeland LI, Borge GI, Halvorsen B et al. Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets. Pediatr Res 2004;56:783-790.
21. Solberg R, Andresen JH, Pettersen S, Wright MS, Munkeby BH, Charrat E et al. Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dosedependent increase in matrix metalloproteinase-activity and down-regulates vital genes. Pediatr Res 2010;67(3):250-256.
22. Lakshminrusimha S, Russell JA, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF et al. Pulmonary hemodynamics in neonatal lambs resuscitated with 21, 50, and 100% oxygen. Pediatr Res 2007;62:313-318.
23. Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin 3rd FC et al. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res 2006;59:137-141.
24. Markus T, Hansson S, Amer-Wahlin I, Hellström-Westas L, Saugstad OD, Ley D. Cerebral inflammatory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep. Pediatr Res 2007;62:71-77.
25. Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG. Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury. J Cereb Blood Flow Metab 2008;28:1294-12306.
26. Vento M, Sastre J, Asensi MA, Viña J. Room-air resuscitation causes less damage to heart and kidney than 100% oxygen. Am J Respir Crit Care Med 2005;172:1393-1398.
27. Oxer HF. Simply add oxygen: why isn't oxygen administration taught in all resuscitation training? Resuscitation 2000;43:163-169.
28. Niermeyer S, Kattwinkel J, Van Reempts P, Nadkarni V, Phillips B, Zideman D et al. International guidelines for neonatal resuscitation: an excerpt from the guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care: international consensus on science. Contributors and reviewers for the neonatal resuscitation guidelines. Pediatrics 2000;106: e29.
29. WHO. Basic Newborn Resuscitation: A Practical Guide. WHO: Geneva, 1998.
30. International Liaison Committee on Resuscitation. The International Liaison Committee on Resuscitation (ILCOR) consensus on science with treatment recommendations for pediatric and neonatal patients: neonatal resuscitation. Pediatrics 2006;117: e978.
31. Saugstad OD, Ramji S, Soll RF, Vento M. Resuscitation of newborn infants with 21 or 100% oxygen: an updated systematic review and meta-analysis. Neonatology 2008;94:176-182.
32. Davis PG, Tan A, O'Donnell CP, Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet 2004;364:1329-1333.
33. Saugstad OD, Ramji S, Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate 2005;87:27-34.
34. Rabi Y, Rabi D, Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation 2007;72:353-363.
35. Linner R, Werner O, Perez-de-Sa V, Cunha-Goncalves D. Circulatory recovery is as fast with air ventilation as with 100% oxygen after asphyxia-induced cardiac arrest in piglets. Pediatr Res 2009;66:391-394.
36. Solevåg AL, Dannevig I, Nakstad B, Saugstad OD. Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21 or 100% oxygen. Neonatology 2010;98:64-72.
37. Yeh ST, Cawley RJ, Aune SE, Angelos MG. Oxygen requirement during cardiopulmonary resuscitation (CPR) to effect return of spontaneous circulation. Resuscitation 2009;80:951-955.
38. Matsiukevich D, Randis TM, Utkina-Sosunova I, Polin RA, Ten VS. The state of systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia-ischemia. Resuscitation 2010;81:224-229.
39. Liu JQ, Saugstad OD, Cheung PY. Using 100% oxygen for the resuscitation of term neonates until evidence of spontaneous circulation: More investigations needed. Resuscitation 2010;81:145-147.
40. Canadian Paediatric Society. Neonatal resuscitation program. http://www.cps.ca.
41. Australian Resuscitation Council. Airway and mask ventilation of the newborn infant. Australian Resuscitation Council February 2006, Guideline 13.4:1-9. Available from http://www.resus.org.au/(Accessed May 2006).
42. van den Dungen FA, van Veenendaal MB, Mulder AL. Clinical practice: neonatal resuscitation. A Dutch consensus. Eur J Pediatr 2010;169:521-527.
43. Resuscitation Council UK. Newborn life support. http://www.resus.org.uk.
44. Escrig R, Arruza L, Izquierdo I, Villar G, Sáenz P, Gimeno A et al. Achievement of targeted saturation values in extremely low gestational age neonates resuscitated with low or high oxygen concentrations: a prospective, randomized trial. Pediatrics 2008;121:875-881.
45. Wang CL, Anderson C, Leone TA, Rich W, Govindaswami B, Finer NN. Resuscitation of preterm neonates by using room air or 100% oxygen. Pediatrics 2008;121:1083-1089.
46. Vento M, Moro M, Escrig R, Arruza L, Villar G, Izquierdo I et al. Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease. Pediatrics 2009;124:439-449.
47. Dawson JA, Kamlin CO, Wong C, te Pas AB, O'Donnell CP, Donath SM et al. Oxygen saturation and heart rate during delivery room resuscitation of infants <30 weeks' gestation with air or 100% oxygen. Arch Dis Child Fetal Neonatal Ed 2009;94: F87-F91.
48. Stola A, Schulman J, Perlman J. Initiating delivery room stabilisation/resuscitation in very low birth weight (VLBW) infants with an FiO2 less than 100% is feasible. J Perinatol 2009;29:548-552.
49. Ezaki S, Suzuki K, Kurishima C, Miura M, Weilin W, Hoshi R et al. Resuscitation of preterm infants with reduced oxygen results in less oxidative stress than resuscitation with 100% oxygen. J Clin Biochem Nutr 2009;44:111-118.
50. Finer N, Saugstad O, Vento M, Barrington K, Davis P, Duara S et al. Use of oxygen for resuscitation of the extremely low birth weight infant. Pediatrics 2010;125(2):389-391.