A forward-genetic screen and dynamic analysis of lambda phage host-dependencies reveals an extensive interaction network and a new anti-viral strategy

PLoS Genetics

Volumn 6, Issue 7, 2010, Pages 1-15

  Maynard, Nathaniel D ^a   Birch, Elsa W ^a   Sanghvi, Jayodita C ^a   Chen, Lu ^a   Gutschow, Miriam V ^a   Covert, Markus W ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID TRANSFER RNA; GLUTAMINE TRANSFER RNA LIGASE; LYSINE TRANSFER RNA; TRANSFER RNA; 2 THIOURIDINE; 2-THIOURIDINE; DRUG DERIVATIVE; THIOURIDINE;

ANTIVIRAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIOPHAGE LAMBDA; BACTERIOPHAGE T7; CONTROLLED STUDY; ESCHERICHIA COLI K 12; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INTERACTION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC SCREENING; KNOCKOUT GENE; MOLECULAR DYNAMICS; NONHUMAN; OBSERVATIONAL STUDY; REGULATOR GENE; RNA PROCESSING; RNA THIOLATION; VIRUS CELL INTERACTION; WILD TYPE; YNEJ GENE; BACTERIAL GENE; ESCHERICHIA COLI; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; PHYSIOLOGY; VIROLOGY; VIRUS GENE; VIRUS REPLICATION;

ENTEROBACTERIA PHAGE LAMBDA; ESCHERICHIA COLI;

BACTERIOPHAGE LAMBDA; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENES, BACTERIAL; GENES, VIRAL; GENETIC TESTING; HOST-PATHOGEN INTERACTIONS; THIOURIDINE; VIRUS REPLICATION;

EID: 77957376210     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001017     Document Type: Article

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