Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp

Frontiers in Bioscience - Elite

Volumn 2 E, Issue 3, 2010, Pages 972-979

  Seki, Yasufumi ^a   Ichihara, Atsuhiro ^a   Mizuguchi, Yuki ^a   Sakoda, Mariyo ^a   Kurauchi Mito, Asako ^a   Narita, Tatsuya ^a   Kinouchi, Kenichiro ^a   Bokuda, Kanako ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin converting enzyme inhibitors; Diabetes; Handle region peptide; Hypertension; Proteinuria

Indexed keywords

ANGIOTENSIN II; CELL SURFACE RECEPTOR; COLLAGEN TYPE 1; IMIDAPRIL; IMIDAZOLIDINE DERIVATIVE; MESSENGER RNA; PRORENIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; DRUG ANTAGONISM; EXPERIMENTAL DIABETES MELLITUS; GENETICS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT;

ANGIOTENSIN II; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; COLLAGEN TYPE I; DIABETES MELLITUS, EXPERIMENTAL; IMIDAZOLIDINES; MALE; ORGAN SIZE; RATS; RATS, INBRED SHR; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 77957375156     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e156     Document Type: Article

References (30)

1. Steinbrook R. Facing the diabetes epidemic-mandatory reporting of glycosylated hemoglobin values in New York city. N Engl J Med 354, 545-548 (2006) (Pubitemid 43209099)
2. Hypertension in Diabetes Study Group (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardio-vascular and diabetic complications. J Hypertens 11, 309-317 (1993)
3. Hypertension in Diabetes Study (HDS): II. Increased risk of cardio-vascular complications in hypertensive type 2 diabetic patients. J Hypertens 11, 319-325 (1993)
4. Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AHMN, Ishida Y, Inagami T, Saruta T. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J Clin Invest 114, 1128-1135 (2004) (Pubitemid 39578702)
5. Ichihara A, Sakoda M, Mito-Kurauchi A, Nishiyama A, Itoh H. Involvement of receptor-bound prorenin in development of nephropathy in db/db mice. J Am Soc Hypertens 2, 332-340 (2008)
6. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Nishiyama A, Inagami T, Hayashi M. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47, 894-900 (2006) (Pubitemid 44297561)
7. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, Kawachi H, Shimizu F, Inagami T. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17, 2495-2503 (2006) (Pubitemid 44300965)
8. Susic D, Zhou X, Frohlich ED, Lippton H, Knight M. Cardiovascular effects of prorenin blockade in genetically hypertensive rats (SHR) on normal and high salt diet. Am J Physiol Heart Circ Physiol 295, H1117-H1121 (2008)
9. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109, 1417-1427 (2002) (Pubitemid 34596167)
10. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W. Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin IIindependent mechanisms. Kidney Int 69, 105-113 (2006) (Pubitemid 43117745)
11. NurunNabi AHM, Uddin M, Nakagawa T, Iwata H, Ichihara A, Inagami T, Suzuki F. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro) renin receptor. Front Biosci 12, 4810-4817 (2007)
12. NurunNabi AHM, Biswas KB, Nakagawa T, Ichihara A, Inagami T, Suzuki F. 'Decoy peptide' region (RIFLKRMPSI) of prorenin prosegment plays a crucial role in prorenin binding to the (pro) renin receptor. Int J Mol Med 24, 83-89 (2009)
13. Nishiyama A, Seth DM, Navar LG. Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition. J Am Soc Nephrol 13, 2207-2212 (2002) (Pubitemid 34925230)
14. Bolbrinker J, Markovic S, Wehland M, Melenhorst WBWH, van Goor H, Kreutz R. Expression and response to angiotensin-converting enzyme inhibition of matrix metalloproteases 2 and 9 in renal glomerular damage in young transgenic rats with renin-dependent hypertension. J Pharmacol Exp Ther 316, 8-16 (2006) (Pubitemid 41832575)
15. Shan Z, Cuadra AE, Sumners C, Raizada MK. Characterization of a functional (pro) renin receptor in rat brain neurons. Exp Physiol 93, 701-708 (2008) (Pubitemid 351595061)
16. Schefe J, Menk M, Reinemund J, Effertz K, Hobbs R, Pandolfi P, Ruiz P, Unger T, Funke-Kaiser H. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 99, 1355-1366 (2006) (Pubitemid 44949671)
17. Feldman DL, Jin L, Xuan H, Contrepas A, Zhou Y, Webb RL, Mueller DN, Feldt S, Cumin F, Maniara W, Persohn E, Schuetz H, Danser J, Nguyen G. Effects of aliskiren on blood pressure, albuminuria, and (pro) renin receptor expression in diabetic TG (mRen-2) 27 rats. Hypertension 52, 130-136 (2008)
18. Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, Nabi AHMN, Nishiyama A, Sugaya T, Hayashi M, Inagami T. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol 17, 1950-1961 (2006) (Pubitemid 44036179)
19. Brilla CG, Weber KT. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 120, 893-901 (1992) (Pubitemid 23002899)
20. Blasi ER, Rocha R, Rudolph AE, Blomme EAG, Polly ML, McMahon EG. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int 63, 1791-1890 (2003)
21. Endemann DH, Touyz RM, Iglarz M, Savoia C, Schiffrin EL. Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 43, 1252-1257 (2004) (Pubitemid 38691747)
22. Zhu A, Yoneda T, Demura M, Karashima S, Usukura M, Yamagishi M, Takeda Y. Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. J Hypertens 27, 800-805 (2009)
23. Burckle CA, Jan Danser AH, Muller DN, Garrelds IM, Gasc JM, Popova E, Plehm R, Peters J, Bader M, Nguyen G. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 47, 552-556 (2006) (Pubitemid 43843874)
24. Muller DN, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder RE, Luft FC, Hilgers KF. (Pro) renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 51, 676-681 (2008) (Pubitemid 351301520)
25. Feldt S, Maschke U, Dechend R, Luft FC, Muller DN. The putative (pro) renin receptor blocker HRP fails to prevent (pro) renin signaling. J Am Soc Nephrol 19, 743-748 (2008)
26. NurunNabi AHM, Kageshima A, Uddin M, Nakagawa T, Park E, Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18, 483-488 (2006)
27. Cousin C, Bracquart D, Contrepas A, Corvol P, Muller L, Nguyen F. Soluble form of the (pro) renin receptor generated by intracellular cleavage by furin is secreted in plasma. Hypertension 53, 1077-1082 (2009)
28. Batenburg WW, Krop MK, Garrelds IM, deVries R, deBruin RJA, Burckle CA, Muller DN, Bader M, Nguyen G, Danser AHJ. Prorenin is the endogenous agonist of the (pro) renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro) renin receptor. J Hypertens 25, 2441-2453 (2007) (Pubitemid 350060383)
29. Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, Kvakan H, Dechend R, Fiebeler A, Burckle C, Contrepas A, Danser AHJ, Bader M, Nguyen G, Luft FC, Muller DN. Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 51, 682-688 (2008) (Pubitemid 351301521)
30. He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol 606, 155-161 (2009)