-
1
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P and Hunter T: Oncogenic kinase signalling. Nature 411: 355-365, 2001.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
2
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F and Normando N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normando, N.4
-
3
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM, Lane HA and Hynes NE: The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19: 3159-3167, 2000.
-
(2000)
EMBO J
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
4
-
-
0037291769
-
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
-
Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ and Lemmon MA: EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11: 507-517, 2003.
-
(2003)
Mol Cell
, vol.11
, pp. 507-517
-
-
Ferguson, K.M.1
Berger, M.B.2
Mendrola, J.M.3
Cho, H.S.4
Leahy, D.J.5
Lemmon, M.A.6
-
5
-
-
0037162799
-
Structure of the extracellular region of HER3 reveals an interdomain tether
-
Cho HS and Leahy DJ: Structure of the extracellular region of HER3 reveals an interdomain tether. Science 297: 1330-1333, 2002.
-
(2002)
Science
, vol.297
, pp. 1330-1333
-
-
Cho, H.S.1
Leahy, D.J.2
-
6
-
-
10744230127
-
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
-
DOI 10.1016/S1097-2765(03)00350-2
-
Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Thomas PJ, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW and Yokoyama S: An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 12: 541-552, 2003. (Pubitemid 37222478)
-
(2003)
Molecular Cell
, vol.12
, Issue.3
, pp. 541-552
-
-
Burgess, A.W.1
Cho, H.-S.2
Eigenbrot, C.3
Ferguson, K.M.4
Garrett, T.P.J.5
Leahy, D.J.6
Lemmon, M.A.7
Sliwkowski, M.X.8
Ward, C.W.9
Yokoyama, S.10
-
7
-
-
67649472398
-
Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3
-
Baselga J and Swain SM: Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 9: 463-475, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 463-475
-
-
Baselga, J.1
Swain, S.M.2
-
9
-
-
3042800393
-
ErbB3/Her3 does not homodimerize upon neuregulin binding at the cell surface
-
Berger MB, Mendrola JM and Lemmon MA: ErbB3/Her3 does not homodimerize upon neuregulin binding at the cell surface. FEBS lett 569: 332-336, 2004.
-
(2004)
FEBS Lett
, vol.569
, pp. 332-336
-
-
Berger, M.B.1
Mendrola, J.M.2
Lemmon, M.A.3
-
10
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE and Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354, 2005.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
11
-
-
33644529055
-
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
-
DOI 10.1158/0008-5472.CAN-04-4559
-
Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN and Yu D: ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 66: 2028-2037, 2006. (Pubitemid 43294911)
-
(2006)
Cancer Research
, vol.66
, Issue.4
, pp. 2028-2037
-
-
Klos, K.S.1
Wyszomierski, S.L.2
Sun, M.3
Tan, M.4
Zhou, X.5
Li, P.6
Yang, W.7
Yin, G.8
Hittelman, W.N.9
Yu, D.10
-
12
-
-
33745828702
-
EGF-ERBB signalling: Towards the systems level
-
Citri A and Yarden Y: EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7: 505-516, 2006.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
13
-
-
33747855481
-
Comparing antibody and small-molecule therapies for cancer
-
DOI 10.1038/nrc1913, PII NRC1913
-
Imai K and Takaoka A: Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6: 714-727, 2006. (Pubitemid 44286003)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.9
, pp. 714-727
-
-
Imai, K.1
Takaoka, A.2
-
14
-
-
46749144174
-
Mechanisms of resistance to ErbB-targeted cancer therapeutics
-
Wang Q and Greene MI: Mechanisms of resistance to ErbB-targeted cancer therapeutics. J Clin Invest 118: 2389-2392, 2008.
-
(2008)
J Clin Invest
, vol.118
, pp. 2389-2392
-
-
Wang, Q.1
Greene, M.I.2
-
15
-
-
46749156706
-
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
-
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL an Engelman JA: Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. Clin Invest 118: 2609-2619, 2008.
-
(2008)
Clin Invest
, vol.118
, pp. 2609-2619
-
-
Guix, M.1
Faber, A.C.2
Wang, S.E.3
Olivares, M.G.4
Song, Y.5
Qu, S.6
Rinehart, C.7
Seidel, B.8
Yee, D.9
Arteaga, C.L.10
Engelman, J.A.11
-
16
-
-
63749101351
-
Targeting the EGFR and the PKB pathway in cancer
-
Klein S and Levitzki A: Targeting the EGFR and the PKB pathway in cancer. Curr Opin Cell Biol 21: 185-193, 2009.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 185-193
-
-
Klein, S.1
Levitzki, A.2
-
17
-
-
33645540607
-
Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy
-
Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T and Mekada E: Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 97: 341-347, 2006.
-
(2006)
Cancer Sci
, vol.97
, pp. 341-347
-
-
Miyamoto, S.1
Yagi, H.2
Yotsumoto, F.3
Kawarabayashi, T.4
Mekada, E.5
-
18
-
-
36549072385
-
Validation of HB-EGF and amphiregulin as targets for human cancer therapy
-
Yotsumoto F, Yagi H, Suzuki SO, Oki E, Tsujioka H, Hachisuga T, Sonoda K, Kawarabayashi T, Mekada E and Miyamoto S: Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem Biophys Res Commun 365: 555-561, 2009.
-
(2009)
Biochem Biophys Res Commun
, vol.365
, pp. 555-561
-
-
Yotsumoto, F.1
Yagi, H.2
Suzuki, S.O.3
Oki, E.4
Tsujioka, H.5
Hachisuga, T.6
Sonoda, K.7
Kawarabayashi, T.8
Mekada, E.9
Miyamoto, S.10
-
19
-
-
22744450061
-
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk
-
DOI 10.1016/j.bbapap.2004.11.009, PII S1570963904003188, Proteolysis
-
Higashiyama S and Nanba D: ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751: 110-117, 2005. (Pubitemid 41033299)
-
(2005)
Biochimica et Biophysica Acta - Proteins and Proteomics
, vol.1751
, Issue.1
, pp. 110-117
-
-
Higashiyama, S.1
Nanba, D.2
-
20
-
-
0025904265
-
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
-
Higashiyama S, Abraham JA, Miller J, Fiddes JC and Klagsbrun M: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251: 936-939, 1991.
-
(1991)
Science
, vol.251
, pp. 936-939
-
-
Higashiyama, S.1
Abraham, J.A.2
Miller, J.3
Fiddes, J.C.4
Klagsbrun, M.5
-
21
-
-
17444373968
-
A metalloprotease-disintegrin MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
-
Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umeta T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S and Mekada E: A metalloprotease- disintegrin MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17: 7260-7272, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 7260-7272
-
-
Izumi, Y.1
Hirata, M.2
Hasuwa, H.3
Iwamoto, R.4
Umeta, T.5
Miyado, K.6
Tamai, Y.7
Kurisaki, T.8
Sehara-Fujisawa, A.9
Ohno, S.10
Mekada, E.11
-
22
-
-
0037224740
-
The ADAMs family of metalloproteases: Multidomain proteins with multiple functions
-
Seals DF and Coutneidges SA: The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 17: 7-30, 1998.
-
(1998)
Genes Dev
, vol.17
, pp. 7-30
-
-
Seals, D.F.1
Coutneidges, S.A.2
-
23
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H, Laserer M, Abraham R, Wallasch C and Ullrich A: EGF receptor transactivation by G-protein-coupled receptor requires metalloproteases cleavage of proHB-EGF. Nature 402: 884-888, 1999. (Pubitemid 129515992)
-
(1999)
Nature
, vol.402
, Issue.6764
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
Leserer, M.4
Abraham, R.5
Wallasch, C.6
Ullrich, A.7
-
24
-
-
0037593847
-
The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades
-
Takenobu H, Yamazaki A, Hirata M, Umeta T and Mekada E: The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades. J Biol Chem 278: 17255-17262, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 17255-17262
-
-
Takenobu, H.1
Yamazaki, A.2
Hirata, M.3
Umeta, T.4
Mekada, E.5
-
25
-
-
0242425875
-
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
-
Nanba D, Mammoto A, Hashimoto K and Higashiyama S: Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol 163: 489-502, 2003.
-
(2003)
J Cell Biol
, vol.163
, pp. 489-502
-
-
Nanba, D.1
Mammoto, A.2
Hashimoto, K.3
Higashiyama, S.4
-
26
-
-
34447529461
-
The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression
-
DOI 10.1074/jbc.M611036200
-
Kinugasa Y, Hieda M, Hori M and Higashiyama S: The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression. J Biol Chem 282: 14797-14806, 2007. (Pubitemid 47093367)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.20
, pp. 14797-14806
-
-
Kinugasa, Y.1
Hieda, M.2
Hori, M.3
Higashiyama, S.4
-
27
-
-
0035839518
-
BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: A unique role for proHB-EGF in cell survival regulation
-
Lin J, Hutchinson L, Gaston SM, Raab G and Freeman MR: BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. J Biol Chem 276: 30127-30132, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 30127-30132
-
-
Lin, J.1
Hutchinson, L.2
Gaston, S.M.3
Raab, G.4
Freeman, M.R.5
-
28
-
-
4143151913
-
Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy
-
Miyamoto S, Hirata M, Yamazaki A, Kageyama T, Hasuwa H, Mizushima H, Tanaka Y, Yagi H, Sonoda K, Kai M, Kanoh H, Nakano H and Mekada E: Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. Cancer Res 64: 5720-5727, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 5720-5727
-
-
Miyamoto, S.1
Hirata, M.2
Yamazaki, A.3
Kageyama, T.4
Hasuwa, H.5
Mizushima, H.6
Tanaka, Y.7
Yagi, H.8
Sonoda, K.9
Kai, M.10
Kanoh, H.11
Nakano, H.12
Mekada, E.13
-
29
-
-
19944391895
-
Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer
-
Yagi H, Miyamoto S, Tanaka Y, Sonoda K, Kobayashi H, Kishikawa T, Iwamoto R, Mekada E and Nakano H: Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer. Br J Cancer 92: 1737-1745, 2005.
-
(2005)
Br J Cancer
, vol.92
, pp. 1737-1745
-
-
Yagi, H.1
Miyamoto, S.2
Tanaka, Y.3
Sonoda, K.4
Kobayashi, H.5
Kishikawa, T.6
Iwamoto, R.7
Mekada, E.8
Nakano, H.9
-
30
-
-
0028860250
-
Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
-
Mitamura T, Higashiyama S, Taniguchi N, Klagsbrun M and Mekada E: Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 270: 1015-1019, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 1015-1019
-
-
Mitamura, T.1
Higashiyama, S.2
Taniguchi, N.3
Klagsbrun, M.4
Mekada, E.5
-
31
-
-
27644466636
-
Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cahceir
-
Tanaka Y, Miyamoto S, Suzuki SO, Oki E, Yagi H, Sonoda K, Yamazaki A, Mizushima H, Maehara Y, Mekada E and Nakano H: Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cahceir. Clin Cancer Res 11: 4783-4792, 2005.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4783-4792
-
-
Tanaka, Y.1
Miyamoto, S.2
Suzuki, S.O.3
Oki, E.4
Yagi, H.5
Sonoda, K.6
Yamazaki, A.7
Mizushima, H.8
Maehara, Y.9
Mekada, E.10
Nakano, H.11
-
32
-
-
55749092776
-
Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition
-
Yagi H, Yotsumoto F and Miyamoto S: Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Mol Cancer Ther 7: 3441-3451, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3441-3451
-
-
Yagi, H.1
Yotsumoto, F.2
Miyamoto, S.3
-
33
-
-
5644239687
-
CRM197 (nontoxic diphtheria toxin): Effects on advanced cancer patients
-
DOI 10.1007/s00262-004-0546-4
-
Buzzi S, Rubboli D, Buzzi G, Buzzi AM, Morisi C and Pironi F: CRM197 (nontoxic diphtheria toxin): effects on advanced cancer patients. Cancer Immunol Immunother 53: 1041-1048, 2004. (Pubitemid 39371748)
-
(2004)
Cancer Immunology, Immunotherapy
, vol.53
, Issue.11
, pp. 1041-1048
-
-
Buzzi, S.1
Rubboli, D.2
Buzzi, G.3
Buzzi, A.M.4
Morisi, C.5
Pironi, F.6
-
34
-
-
60549113956
-
Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer
-
Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E and Miyamoto S: Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. Int J Cancer 124: 1429-1439, 2009.
-
(2009)
Int J Cancer
, vol.124
, pp. 1429-1439
-
-
Yagi, H.1
Yotsumoto, F.2
Sonoda, K.3
Kuroki, M.4
Mekada, E.5
Miyamoto, S.6
-
35
-
-
55749092281
-
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts
-
Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, Higaki JN, Jorgensen B, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Kumari R, Watson SA, Zhang J and Shepard HM: Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. Mol Cancer Ther 7: 3223-3236, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3223-3236
-
-
Sarup, J.1
Jin, P.2
Turin, L.3
Bai, X.4
Beryt, M.5
Brdlik, C.6
Higaki, J.N.7
Jorgensen, B.8
Lau, F.W.9
Lindley, P.10
Liu, J.11
Ni, I.12
Rozzelle, J.13
Kumari, R.14
Watson, S.A.15
Zhang, J.16
Shepard, H.M.17
-
36
-
-
59649109855
-
Rational optimization of a bispecific ligand trap targeting EGF receptor family ligands
-
Jin P, Zhang J, Beryt M, Turin L, Brdlik C, Feng Y, Bai X, Liu J and Jorgensen B, Shepard HM: Rational optimization of a bispecific ligand trap targeting EGF receptor family ligands. Mol Med 15: 11-20, 2009.
-
(2009)
Mol Med
, vol.15
, pp. 11-20
-
-
Jin, P.1
Zhang, J.2
Beryt, M.3
Turin, L.4
Brdlik, C.5
Feng, Y.6
Bai, X.7
Liu, J.8
Jorgensen, B.9
Shepard, H.M.10
|