메뉴 건너뛰기




Volumn 70, Issue C, 2010, Pages 327-340

DNA demethylating agents and epigenetic therapy of cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HISTONE; HISTONE DEACETYLASE INHIBITOR; MICRORNA;

EID: 77957367695     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-380866-0.60012-5     Document Type: Book
Times cited : (47)

References (74)
  • 1
    • 64049094851 scopus 로고    scopus 로고
    • Epigenetic therapies in haematological malignancies: Searching for true targets
    • Altucci L., Minucci S. Epigenetic therapies in haematological malignancies: Searching for true targets. Eur. J. Cancer 2009, 45:1137-1145.
    • (2009) Eur. J. Cancer , vol.45 , pp. 1137-1145
    • Altucci, L.1    Minucci, S.2
  • 2
    • 4544250024 scopus 로고    scopus 로고
    • Gene-promoter hypermethylation as a biomarker in lung cancer
    • Belinsky S.A. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat. Rev. Cancer 2004, 4:707-717.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 707-717
    • Belinsky, S.A.1
  • 4
    • 21244467166 scopus 로고    scopus 로고
    • Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
    • Bhalla K.N. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J. Clin. Oncol. 2005, 23:3971-3993.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3971-3993
    • Bhalla, K.N.1
  • 5
    • 40449132791 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling
    • Bicaku E., Marchion D.C., Schmitt M.L., Munster P.N. Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 2008, 68:1513-1519.
    • (2008) Cancer Res. , vol.68 , pp. 1513-1519
    • Bicaku, E.1    Marchion, D.C.2    Schmitt, M.L.3    Munster, P.N.4
  • 6
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16:6-21.
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 8
    • 33746407333 scopus 로고    scopus 로고
    • The emerging science of epigenomics
    • Special No 1
    • Callinan P.A., Feinberg A.P. The emerging science of epigenomics. Hum. Mol. Genet. 2006, 15(Special No 1):R95-R101.
    • (2006) Hum. Mol. Genet. , vol.15
    • Callinan, P.A.1    Feinberg, A.P.2
  • 9
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron E.E., Bachman K.E., Myohanen S., Herman J.G., Baylin S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet. 1999, 21:103-107.
    • (1999) Nat. Genet. , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 10
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • Cashen A.F., Schiller G.J., O'Donnell M.R., DiPersio J.F. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J. Clin. Oncol. 2010, 28:556-561.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3    DiPersio, J.F.4
  • 12
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G., Liang G., Aparicio A., Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429:457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 13
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 2007, 8:286-298.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 286-298
    • Esteller, M.1
  • 14
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg A.P., Tycko B. The history of cancer epigenetics. Nat. Rev. Cancer 2004, 4:143-153.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 16
    • 0037424541 scopus 로고    scopus 로고
    • A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase
    • Flynn J., Fang J.Y., Mikovits J.A., Reich N.O. A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. J. Biol. Chem. 2003, 278:8238-8243.
    • (2003) J. Biol. Chem. , vol.278 , pp. 8238-8243
    • Flynn, J.1    Fang, J.Y.2    Mikovits, J.A.3    Reich, N.O.4
  • 17
    • 0037528723 scopus 로고    scopus 로고
    • Drug reactivates genes to inhibit cancer
    • Foubister V. Drug reactivates genes to inhibit cancer. Drug Discov. Today 2003, 8:430-431.
    • (2003) Drug Discov. Today , vol.8 , pp. 430-431
    • Foubister, V.1
  • 19
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W.G., Faderl S., Koller C., Morris G., Rosner G., Loboda A., Fantin V.R., et al. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008, 111:1060-1066.
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3    Ferrajoli, A.4    Cortes, J.5    Wierda, W.G.6    Faderl, S.7    Koller, C.8    Morris, G.9    Rosner, G.10    Loboda, A.11    Fantin, V.R.12
  • 20
    • 3242657117 scopus 로고    scopus 로고
    • The clinical application of targeting cancer through histone acetylation and hypomethylation
    • Gilbert J., Gore S.D., Herman J.G., Carducci M.A. The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin. Cancer Res. 2004, 10:4589-4596.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4589-4596
    • Gilbert, J.1    Gore, S.D.2    Herman, J.G.3    Carducci, M.A.4
  • 21
    • 64049097640 scopus 로고    scopus 로고
    • The promises and pitfalls of epigenetic therapies in solid tumours
    • Graham J.S., Kaye S.B., Brown R. The promises and pitfalls of epigenetic therapies in solid tumours. Eur. J. Cancer 2009, 45:1129-1136.
    • (2009) Eur. J. Cancer , vol.45 , pp. 1129-1136
    • Graham, J.S.1    Kaye, S.B.2    Brown, R.3
  • 23
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman J.G., Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 2003, 349:2042-2054.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 24
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R., Bird A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat. Genet. 2003, 33(Suppl.):245-254.
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 25
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293:1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 27
    • 0037143444 scopus 로고    scopus 로고
    • Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation
    • Johnson L., Cao X., Jacobsen S. Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation. Curr. Biol. 2002, 12:1360-1367.
    • (2002) Curr. Biol. , vol.12 , pp. 1360-1367
    • Johnson, L.1    Cao, X.2    Jacobsen, S.3
  • 28
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P.A., Baylin S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 2002, 3:415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 29
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones P.A., Baylin S.B. The epigenomics of cancer. Cell 2007, 128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 30
    • 29244457579 scopus 로고    scopus 로고
    • A blueprint for a human epigenome project: The AACR human epigenome workshop
    • Jones P.A., Martienssen R. A blueprint for a human epigenome project: The AACR human epigenome workshop. Cancer Res. 2005, 65:11241-11246.
    • (2005) Cancer Res. , vol.65 , pp. 11241-11246
    • Jones, P.A.1    Martienssen, R.2
  • 31
    • 17344366283 scopus 로고    scopus 로고
    • Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells
    • Joung K.E., Kim D.K., Sheen Y.Y. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch. Pharm. Res. 2004, 27:640-645.
    • (2004) Arch. Pharm. Res. , vol.27 , pp. 640-645
    • Joung, K.E.1    Kim, D.K.2    Sheen, Y.Y.3
  • 32
    • 1642580501 scopus 로고    scopus 로고
    • Apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells by enhancing the activation of mitochondria-dependent caspase cascades
    • Kim J.S., Jeung H.K., Cheong J.W., Maeng H., Lee S.T., Hahn J.S., Ko Y.W., Min Y.H. Apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells by enhancing the activation of mitochondria-dependent caspase cascades. Br. J. Haematol. 2004, 124:166-178.
    • (2004) Br. J. Haematol. , vol.124 , pp. 166-178
    • Kim, J.S.1    Jeung, H.K.2    Cheong, J.W.3    Maeng, H.4    Lee, S.T.5    Hahn, J.S.6    Ko, Y.W.7    Min, Y.H.8
  • 34
    • 20544473454 scopus 로고    scopus 로고
    • Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: A potential strategy for uveal melanoma
    • Klisovic D.D., Klisovic M.I., Effron D., Liu S., Marcucci G., Katz S.E. Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: A potential strategy for uveal melanoma. Melanoma Res. 2005, 15:147-153.
    • (2005) Melanoma Res. , vol.15 , pp. 147-153
    • Klisovic, D.D.1    Klisovic, M.I.2    Effron, D.3    Liu, S.4    Marcucci, G.5    Katz, S.E.6
  • 35
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird P.W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 2003, 3:253-266.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 36
    • 17444417521 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Spec No 1
    • Laird P.W. Cancer epigenetics. Hum. Mol. Genet. 2005, 14(Spec No 1):R65-R76.
    • (2005) Hum. Mol. Genet. , vol.14
    • Laird, P.W.1
  • 37
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genome-wide DNA methylation analysis
    • Laird P.W. Principles and challenges of genome-wide DNA methylation analysis. Nat. Rev. Genet. 2010, 11:191-203.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 39
    • 0035893767 scopus 로고    scopus 로고
    • Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide
    • Lin X., Asgari K., Putzi M.J., Gage W.R., Yu X., Cornblatt B.S., Kumar A., Piantadosi S., DeWeese T.L., De Marzo A.M., Nelson W.G. Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. Cancer Res. 2001, 61:8611-8616.
    • (2001) Cancer Res. , vol.61 , pp. 8611-8616
    • Lin, X.1    Asgari, K.2    Putzi, M.J.3    Gage, W.R.4    Yu, X.5    Cornblatt, B.S.6    Kumar, A.7    Piantadosi, S.8    DeWeese, T.L.9    De Marzo, A.M.10    Nelson, W.G.11
  • 40
    • 59449084559 scopus 로고    scopus 로고
    • Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment
    • Lin Z., Bazzaro M., Wang M.C., Chan K.C., Peng S., Roden R.B. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin. Cancer Res. 2009, 15:570-577.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 570-577
    • Lin, Z.1    Bazzaro, M.2    Wang, M.C.3    Chan, K.C.4    Peng, S.5    Roden, R.B.6
  • 41
    • 4744344066 scopus 로고    scopus 로고
    • Epigenetics and cancer
    • Lund A.H., van Lohuizen M. Epigenetics and cancer. Genes Dev. 2004, 18:2315-2335.
    • (2004) Genes Dev. , vol.18 , pp. 2315-2335
    • Lund, A.H.1    van Lohuizen, M.2
  • 42
    • 56149090684 scopus 로고    scopus 로고
    • Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead
    • Mai A., Altucci L. Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead. Int. J. Biochem. Cell Biol. 2009, 41:199-213.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 199-213
    • Mai, A.1    Altucci, L.2
  • 43
    • 0036328030 scopus 로고    scopus 로고
    • Diabetes: A candidate disease for efficient DNA methylation profiling
    • Maier S., Olek A. Diabetes: A candidate disease for efficient DNA methylation profiling. J. Nutr. 2002, 132:2440S-2443S.
    • (2002) J. Nutr. , vol.132
    • Maier, S.1    Olek, A.2
  • 44
    • 28644440158 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Discovery and development as anticancer agents
    • Marks P.A., Dokmanovic M. Histone deacetylase inhibitors: Discovery and development as anticancer agents. Expert Opin. Investig. Drugs 2005, 14:1497-1511.
    • (2005) Expert Opin. Investig. Drugs , vol.14 , pp. 1497-1511
    • Marks, P.A.1    Dokmanovic, M.2
  • 45
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks P.A., Richon V.M., Rifkind R.A. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer Inst. 2000, 92:1210-1216.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 48
    • 31444438952 scopus 로고    scopus 로고
    • Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome
    • Maslak P., Chanel S., Camacho L.H., Soignet S., Pandolfi P.P., Guernah I., Warrell R., Nimer S. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Leukemia 2006, 20:212-217.
    • (2006) Leukemia , vol.20 , pp. 212-217
    • Maslak, P.1    Chanel, S.2    Camacho, L.H.3    Soignet, S.4    Pandolfi, P.P.5    Guernah, I.6    Warrell, R.7    Nimer, S.8
  • 49
    • 1642402966 scopus 로고    scopus 로고
    • Cardiac histone acetylation-therapeutic opportunities abound
    • McKinsey T.A., Olson E.N. Cardiac histone acetylation-therapeutic opportunities abound. Trends Genet. 2004, 20:206-213.
    • (2004) Trends Genet. , vol.20 , pp. 206-213
    • McKinsey, T.A.1    Olson, E.N.2
  • 50
    • 0037455915 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer initiation and progression
    • Nephew K.P., Huang T.H. Epigenetic gene silencing in cancer initiation and progression. Cancer Lett. 2003, 190:125-133.
    • (2003) Cancer Lett. , vol.190 , pp. 125-133
    • Nephew, K.P.1    Huang, T.H.2
  • 51
    • 33645010140 scopus 로고    scopus 로고
    • Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines
    • Noguchi M., Yokoyama M., Watanabe S., Uchiyama M., Nakao Y., Hara K., Iwasaka T. Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines. Cancer Lett. 2006, 234:135-142.
    • (2006) Cancer Lett. , vol.234 , pp. 135-142
    • Noguchi, M.1    Yokoyama, M.2    Watanabe, S.3    Uchiyama, M.4    Nakao, Y.5    Hara, K.6    Iwasaka, T.7
  • 53
    • 34248329903 scopus 로고    scopus 로고
    • Review: Recent clinical trials in epigenetic therapy
    • Oki Y., Issa J.P. Review: Recent clinical trials in epigenetic therapy. Rev. Recent Clin. Trials 2006, 1:169-182.
    • (2006) Rev. Recent Clin. Trials , vol.1 , pp. 169-182
    • Oki, Y.1    Issa, J.P.2
  • 54
    • 67349264883 scopus 로고    scopus 로고
    • Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells
    • Park S.J., Kim M.J., Kim H.B., Sohn H.Y., Bae J.H., Kang C.D., Kim S.H. Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells. Exp. Cell Res. 2009, 315:1809-1818.
    • (2009) Exp. Cell Res. , vol.315 , pp. 1809-1818
    • Park, S.J.1    Kim, M.J.2    Kim, H.B.3    Sohn, H.Y.4    Bae, J.H.5    Kang, C.D.6    Kim, S.H.7
  • 55
    • 23744495968 scopus 로고    scopus 로고
    • Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A
    • Reid G., Metivier R., Lin C.Y., Denger S., Ibberson D., Ivacevic T., Brand H., Benes V., Liu E.T., Gannon F. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene 2005, 24:4894-4907.
    • (2005) Oncogene , vol.24 , pp. 4894-4907
    • Reid, G.1    Metivier, R.2    Lin, C.Y.3    Denger, S.4    Ibberson, D.5    Ivacevic, T.6    Brand, H.7    Benes, V.8    Liu, E.T.9    Gannon, F.10
  • 56
    • 21244447049 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
    • Rudek M.A., Zhao M., He P., Hartke C., Gilbert J., Gore S.D., Carducci M.A., Baker S.D. Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J. Clin. Oncol. 2005, 23:3906-3911.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3906-3911
    • Rudek, M.A.1    Zhao, M.2    He, P.3    Hartke, C.4    Gilbert, J.5    Gore, S.D.6    Carducci, M.A.7    Baker, S.D.8
  • 57
    • 49649128638 scopus 로고    scopus 로고
    • Epigenetic drivers and genetic passengers on the road to cancer
    • Sawan C., Vaissiere T., Murr R., Herceg Z. Epigenetic drivers and genetic passengers on the road to cancer. Mutat. Res. 2008, 642:1-13.
    • (2008) Mutat. Res. , vol.642 , pp. 1-13
    • Sawan, C.1    Vaissiere, T.2    Murr, R.3    Herceg, Z.4
  • 59
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • Seligson D.B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., Kurdistani S.K. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005, 435:1262-1266.
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 61
    • 0013773866 scopus 로고
    • 5-Azacytidine, a new, highly effective cancerostatic
    • Sorm F., Piskala A., Cihak A., Vesely J. 5-Azacytidine, a new, highly effective cancerostatic. Experientia 1964, 20:202-203.
    • (1964) Experientia , vol.20 , pp. 202-203
    • Sorm, F.1    Piskala, A.2    Cihak, A.3    Vesely, J.4
  • 62
    • 71149113328 scopus 로고    scopus 로고
    • Decitabine treatment of patients with higher-risk myelodysplastic syndromes
    • Steensma D.P. Decitabine treatment of patients with higher-risk myelodysplastic syndromes. Leuk. Res. 2009, 33(Suppl. 2):S12-S17.
    • (2009) Leuk. Res. , vol.33 , Issue.SUPPL. 2
    • Steensma, D.P.1
  • 63
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 64
    • 2642574054 scopus 로고    scopus 로고
    • CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1
    • Ting A.H., Jair K.W., Suzuki H., Yen R.W., Baylin S.B., Schuebel K.E. CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nat. Genet. 2004, 36:582-584.
    • (2004) Nat. Genet. , vol.36 , pp. 582-584
    • Ting, A.H.1    Jair, K.W.2    Suzuki, H.3    Yen, R.W.4    Baylin, S.B.5    Schuebel, K.E.6
  • 66
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies
    • Urdinguio R.G., Sanchez-Mut J.V., Esteller M. Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies. Lancet Neurol. 2009, 8:1056-1072.
    • (2009) Lancet Neurol. , vol.8 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 67
    • 14644396228 scopus 로고    scopus 로고
    • Detection and interpretation of altered methylation patterns in cancer cells
    • Ushijima T. Detection and interpretation of altered methylation patterns in cancer cells. Nat. Rev. Cancer 2005, 5:223-231.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 223-231
    • Ushijima, T.1
  • 68
    • 47849083984 scopus 로고    scopus 로고
    • Epigenetic interplay between histone modifications and DNA methylation in gene silencing
    • Vaissiere T., Sawan C., Herceg Z. Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat. Res. 2008, 659:40-48.
    • (2008) Mutat. Res. , vol.659 , pp. 40-48
    • Vaissiere, T.1    Sawan, C.2    Herceg, Z.3
  • 69
    • 2942594292 scopus 로고    scopus 로고
    • The effects of 5-aza-2'-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes
    • van den Bosch J., Lubbert M., Verhoef G., Wijermans P.W. The effects of 5-aza-2'-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes. Leuk. Res. 2004, 28:785-790.
    • (2004) Leuk. Res. , vol.28 , pp. 785-790
    • van den Bosch, J.1    Lubbert, M.2    Verhoef, G.3    Wijermans, P.W.4
  • 70
    • 0036176617 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer treatment
    • Vigushin D.M., Coombes R.C. Histone deacetylase inhibitors in cancer treatment. Anticancer Drugs 2002, 13:1-13.
    • (2002) Anticancer Drugs , vol.13 , pp. 1-13
    • Vigushin, D.M.1    Coombes, R.C.2
  • 71
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea A., Fraga M.F., Espada J., Esteller M. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res. 2003, 63:4984-4989.
    • (2003) Cancer Res. , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 73
    • 20344394418 scopus 로고    scopus 로고
    • Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid
    • Yang H., Hoshino K., Sanchez-Gonzalez B., Kantarjian H., Garcia-Manero G. Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid. Leuk. Res. 2005, 29:739-748.
    • (2005) Leuk. Res. , vol.29 , pp. 739-748
    • Yang, H.1    Hoshino, K.2    Sanchez-Gonzalez, B.3    Kantarjian, H.4    Garcia-Manero, G.5
  • 74
    • 77749342644 scopus 로고    scopus 로고
    • Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: Perspectives for therapeutics
    • Zhou X., Yang X.Y., Popescu N.C. Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: Perspectives for therapeutics. Int. J. Oncol. 2010, 36:999-1005.
    • (2010) Int. J. Oncol. , vol.36 , pp. 999-1005
    • Zhou, X.1    Yang, X.Y.2    Popescu, N.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.