Characterization of polyamine homeostasis in l-ornithine-induced acute pancreatitis in rats

Pancreas

Volumn 39, Issue 7, 2010, Pages 1047-1056

  Biczó, György ^a   Hegyi, Péter ^a   Sinervirta, Riitta ^b   Berczi, Sándor ^a   Dósa, Sándor ^a   Siska, Andrea ^a   Iványi, Béla ^a   Venglovecz, Viktória ^a   Takács, Tamás ^a   Alhonen, Leena ^b   Rakonczay, Zoltán ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

L ornithine; pancreatitis; polyamines

Indexed keywords

AMYLASE; HEAT SHOCK PROTEIN 72; I KAPPA B ALPHA; METHYLSPERMIDINE; MYELOPEROXIDASE; ORNITHINE; ORNITHINE DECARBOXYLASE; POLYAMINE DERIVATIVE; PUTRESCINE; SPERMIDINE; SPERMINE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOLOGY; HOMEOSTASIS; LIVER PARENCHYMA; LUNG PARENCHYMA; MALE; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL LIPASE BLOOD LEVEL;

ACETYLTRANSFERASES; ACUTE DISEASE; ANIMALS; BIOGENIC POLYAMINES; CREATININE; HOMEOSTASIS; HSP72 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; LIVER; LUNG; MALE; ORNITHINE; PANCREAS; PANCREATITIS; RATS; RATS, WISTAR;

EID: 77957346487     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181d3cdf0     Document Type: Article

References (25)

1. Wallace HM, Fraser AV, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14.
2. Moinard C, Cynober L, de Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr. 2005;24:184-197.
3. Löser C, Fölsch UR, Cleffmann U, et al. Role of ornithine decarboxylase and polyamines in camostate (Foy-305)-induced pancreatic growth in rats. Digestion. 1989;43:98-112.
4. Jänne J, Alhonen L, Pietilä M, et al. Genetic approaches to the cellular functions of polyamines in mammals. Eur J Biochem. 2004;271:877-894.
5. Alhonen L, Parkkinen JJ, Keinänen T, et al. Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proc Natl Acad Sci U S A. 2000;97:8290-8295.
6. Hyvönen MT, Herzig KH, Sinervirta R, et al. Activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. Am J Pathol. 2006;168:115-122.
7. Hyvönen MT, Merentie M, Uimari A, et al. Mechanisms of polyamine catabolism-induced acute pancreatitis. Biochem Soc Trans. 2007;35:326-330.
8. Jin HT, Lämsä T, Merentie M, et al. Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis. Pancreatology. 2008;8:15-24.
9. Rakonczay Z Jr, Hegyi P, Dósa S, et al. A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats. Crit Care Med. 2008;36:2117-2127.
10. Grigorenko NA, Vepsäläinen J, Järvinen A, et al. A new synthesis of alpha-methylspermidine. Bioorgan Khim (Moscow). 2004;30:441-445.
11. Hyvönen T, Keinänen TA, Khomutov AR, et al. Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography. J Chromatogr. 1992;574:17-21.
12. Jänne J, Williams-Ashman HG. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme. J Biol Chem. 1971;246:1725-1732
13. Bernacki RJ, Bergeron RJ, Porter CW. N,N'-bis(ethyl) spermine homologues against human MALME-3 melanoma xenografts. Cancer Res. 1992;52:2424-2430.
14. Kuebler WM, Abels C, Schuerer L, et al. Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc Clin Exp. 1996;16:89-97.
15. Rakonczay Z Jr, Jármay K, Kaszaki J, et al. NF-kappaB activation is detrimental in arginineinduced acute pancreatitis. Free Radic Biol Med. 2003;34:696-709.
16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
17. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
18. Kurucz I, Tombor B, Prechl J, et al. Ultrastructural localization of HSP-72 examined with a new polyclonal antibody raised against the truncated variable domain of the heat shock protein. Cell Stress Chaperones. 1999;4:139-152.
19. Rakonczay Z Jr, Takács T, Boros I, et al. Heat shock proteins and the pancreas. J Cell Physiol. 2003;195:383-391.
20. Rakonczay Z Jr, Hegyi P, Takács T, et al. The role of NF-JB activation in the pathogenesis of acute pancreatitis. Gut. 2008;57:259-267.
21. Pirinen E, Kuulasmaa T, Pietilä M, et al. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. Mol Cell Biol. 2007;27:4953-4967.
22. Jin HT, Lämsä T, Hyvönen MT, et al. A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. Surgery. 2008;144:49-56.
23. Lakanen JR, Coward JK, Pegg AE. alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. J Med Chem. 1992;35:724-734.
24. Järvinen A, Grigorenko N, Khomutov AR, et al. Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines. J Biol Chem. 2005;280:6595-6601.
25. Räsänen TL, Alhonen L, Sinervirta R, et al. A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. J Biol Chem. 2002;277:39867-39872.