Evaluation of concentration-response options for diacetyl in support of occupational risk assessment

Regulatory Toxicology and Pharmacology

Volumn 58, Issue 2, 2010, Pages 285-296

  Maier, Andrew ^a   Kohrman Vincent, Melissa ^a   Parker, Ann ^a   Haber, Lynne T ^a  

^a Toxicology Excellence for Risk Assessment   (United States)

Author keywords

Concentration response; Diacetyl; Occupational exposure limit; Risk assessment

Indexed keywords

2,3 BUTANEDIONE;

ARTICLE; BRONCHIOLITIS OBLITERANS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; HAZARD ASSESSMENT; HUMAN; MEDICAL LITERATURE; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT DISEASE; RISK ASSESSMENT; SPECIES DIFFERENCE;

ANIMALS; DIACETYL; HUMANS; INHALATION EXPOSURE; MAXIMUM ALLOWABLE CONCENTRATION; MICE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; RESPIRATORY SYSTEM; RISK ASSESSMENT; SPECIES SPECIFICITY; THRESHOLD LIMIT VALUES;

ANIMALIA; MUS;

EID: 77957335774     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.06.011     Document Type: Article

References (50)

1. Akpinar-Elci M., et al. Exhaled nitric oxide measurement in workers in a microwave popcorn production plant. Int. J. Occup. Environ. Health 2006, 12:106-110.
2. Akpinar-Elci M., et al. Induced sputum evaluation in microwave popcorn production workers. Chest 2005, 128:991-997.
3. Akpinar-Elci M., et al. Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur. Respir. J. 2004, 24:298-302.
4. Allen B.C., et al. Dose-response assessment for developmental toxicity II. Comparison of generic benchmark dose estimates with no observed adverse effect levels. Fundam. Appl. Toxicol. 1994, 23:487-495.
5. Anderson S.E., et al. Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry. Toxicol. Sci. 2007, 97:355-363.
6. Ashley K., et al. Analytical performance criteria: field evaluation of diacetyl sampling and analytical methods. J. Occup. Environ. Hyg. 2008, 5:D11-D16.
7. Bailey, R. et al., 2008. Report on fixed obstructive lung disease in workers at a flavoring manufacturing plant. Health Hazard Evaluation Report 2007-0033-3074. Gold Coast Ingredients, Inc., October 2008.
8. Boylstein R., et al. Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn production. J. Occup. Environ. Med. 2006, 3:530-535.
9. Colley J., et al. Acute and short-term toxicity of diacetyl in rats. Fd Cosmet. Toxicol. 1969, 7:571-580.
10. FDA, 1973. Teratologic evaluation of FDA 71-73 (starter distillate, Hansen). NTIS PB-245-431 (FDABG-GRAS-275).
11. Fedan J.S., et al. Popcorn worker's lung: in vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine. Toxicol. Appl. Pharmacol. 2006, 215:17-22.
12. FEMA, 2004. Respiratory Health and Safety in the Flavor Manufacturing Workplace. The Flavor and Extract Manufacturers Association of the United States (FEMA). Washington, DC.
13. Galbraith D., Weill D. Popcorn lung and bronchiolitis obliterans: a critical appraisal. Int. Arch. Occup. Environ. Health 2009, 82:407-416.
14. Grutters J.C., du Bois R.M. Genetics of fibrosing lung diseases. Eur. Respir. J. 2005, 25:915-927.
15. Harber P., et al. Letter to the editor. RE popcorn lung and bronchiolitis obliterans: a critical appraisal. Int. Arch. Occup. Environ. Health 2009, 82:407-416.
16. Harber P., et al. Diacetyl-induced lung disease. Toxicol. Rev. 2006, 25:261-272.
17. Hubbs A.F., et al. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 2002, 185:128-135.
18. Hubbs A.F., et al. Respiratory toxicologic pathology of inhaled diacetyl in Sprague-Dawley rats. Toxicol. Pathol. 2008, 36:330-344.
19. Kanwal, R. et al., 2004. Health Hazard Evaluation Report 2001-0474-2943 (HETA #2001-0474-2943): American Pop Corn Company, Sioux City, Iowa. NIOSH Health Hazard Evaluation Report. National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH.
20. Kanwal, R., Kullman, G., 2004. HETA #2003-0112-2949, ConAgra Snack Foods, Marion, Ohio. NIOSH Health Hazard Evaluation Report. National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH.
21. Kanwal, R. et al., 2006a. HETA #2000-0401-2991, Glister-Mary Lee Corporation, Jasper, Missouri. NIOSH Health Hazard Evaluation Report. National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH.
22. Kanwal R., et al. Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. JOEM 2006, 48:149-157.
23. Kanwal, R., Kullman, G. 2007. HETA #2006-0303-3043, Report on severe fixed obstructive lung disease in workers at a flavoring manufacturing plant. Health Hazard Evaluation Report. National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH.
24. King T.E. Bronchiolitis obliterans. Lung 1989, 167:69-93.
25. Kreiss K. Flavoring-related bronchiolitis obliterans. Curr. Opin. Allergy Clin. Immunol. 2007, 7:162-167.
26. Kreiss K., et al. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 2002, 347:330-338.
27. Kullman G., Boylstein R., Jones W., Piacitelli C., Pendergrass S., Kreiss K. Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans. J. Occup. Environ. Hyg. 2005, 2:169-178.
28. Kullman, G., Sahakian, N., 2007. HETA 2006-0195-3044: Yatsko's Popcorn, Sand Coulee, Montana. NIOSH Health Hazard Evaluation Report. National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH.
29. Larsen S.T., et al. Acute airway effects of diacetyl in mice. Inhal. Toxicol. 2009, 21:1123-1128.
30. Leikauf G.D., et al. Functional genomics of oxidant-induced lung injury. Adv. Exp. Med. Biol. 2001, 500:479-487.
31. Lockey J.E., et al. Airway obstruction related to diacetyl exposure at microwave popcorn production facilities. Eur. Respir. J. 2009, 34:63-71.
32. McConnell, R., Hartle, R., 1986. HETA 85-171-1710, International Bakers Services, Inc., South Bend, Indiana. NIOSH Health Hazard Evaluation Report. National Institute of Occupational Safety and Health, Cincinnati, OH.
33. Morgan D.L., et al. Respiratory toxicity of diacetyl in C57BI/6 Mice. Toxicol. Sci. 2008, 103:169-180.
34. Morris J.B., Hubbs A.F. Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors. Toxicol. Sci. 2009, 108:173-183.
35. NIOSH, 2002. NIOSH Health Hazard Evaluation Report: Nebraska popcorn close-out report. NIOSH Health Hazard Evaluation Report. National Institute for Occupational Safety and Health (NIOSH).
36. NTP Chemical information review document for artificial butter flavoring and constituents: diacetyl [CAS No. 431-03-8] and acetoin [CAS No. 513-86-0] 2007, Integrated Laboratory Systems, Inc., Research Triangle Park, NC.
37. NTP, 2009. 2,3-Butanedione. Testing Status of Agents at NTP National Toxicology Program. M940009.
38. Old L., et al. Evaluation of a local exhaust ventilation system for controlling exposures during liquid flavoring production. J. Occup. Environ. Hyg. 2008, 5:D103-D110.
39. Parmet A.J., von Essen S. Rapidly progressive, fixed airway obstructive disease in popcorn workers: a new occupational pulmonary illness? JOEM 2002, 44:216-218.
40. 2 absorption. Toxicology 1994, 89:217-237.
41. Roberts D.W., et al. Structure-activity relationships in the murine local lymph node assay for skin sensitization: α,b-diketones. Contact Dermatitis 1999, 41:14-17.
42. Rose C., et al. Respiratory symptoms and airflow limitation in flavor manufacturing workers. Am. J. Respir. Crit. Care Med. 2007, 175:A17.
43. Sahakian, 2003. HETA 2002-0408-2915, Agrilink Foods Popcorn Plant, Ridgway, Illinois. NIOSH Heatlh Hazard Evaluation Report. National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH.
44. Sahakian N., et al. Asthma arising in flavoring-exposed food production workers. Int. J. Occup. Med. Environ. Health 2008, 21:173-177.
45. Stoner G.D., et al. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer Res. 1973, 33:3069-3085.
46. US EPA (US Environmental Protection Agency), Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry 1994, Office of Research and Development, Washington, DC.
47. van Rooy F.G.B.G.J., et al. Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. Am. J. Respir. Crit. Care Med. 2007, 176:498-504.
48. van Rooy F.G.B.G.J., et al. A cross sectional study on lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. Occup. Environ. Med. 2009, 66:105-110.
49. Wallace W.A.H., et al. Inflammation-associated remodelling and fibrosis in the lung: a process and an end point. Int. J. Exp. Path. 2007, 88:103-110.
50. Whittaker P., et al. Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Food Chem. Toxicol. 2008, 46:2928-2933.