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Volumn 21, Issue 3, 2010, Pages 219-221

IL-15 in HIV infection: Pathogenic or therapeutic potential?

Author keywords

AIDS; HIV; IL 15; T cells

Indexed keywords

ADJUVANT; ANTIRETROVIRUS AGENT; INTERLEUKIN 15;

EID: 77957335238     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2010.0198     Document Type: Review
Times cited : (19)

References (35)
  • 2
    • 0029946063 scopus 로고    scopus 로고
    • IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
    • Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 1996; 4: 329.
    • (1996) Immunity , vol.4 , pp. 329
    • Tagaya, Y.1    Bamford, R.N.2    DeFilippis, A.P.3    Waldmann, T.A.4
  • 3
    • 10744224313 scopus 로고    scopus 로고
    • Caspase-dependent and - Independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: Relationship to disease progression
    • Arnoult D, Petit F, Lelievre JD, et al. Caspase-dependent and - independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression. Cell Death Differ 2003; 10: 1240.
    • (2003) Cell Death Differ , vol.10 , pp. 1240
    • Arnoult, D.1    Petit, F.2    Lelievre, J.D.3
  • 4
    • 0031570451 scopus 로고    scopus 로고
    • IL-15 enhances immune functions during HIV infection
    • Chehimi J, Marshall JD, Salvucci O, et al. IL-15 enhances immune functions during HIV infection. J Immunol 1997; 158: 5978.
    • (1997) J Immunol , vol.158 , pp. 5978
    • Chehimi, J.1    Marshall, J.D.2    Salvucci, O.3
  • 5
    • 0030587823 scopus 로고    scopus 로고
    • IL-15 stimulates the expansion of AIDS virus-specific CTL
    • Kanai T, Thomas EK, Yasutomi Y, Letvin NL. IL-15 stimulates the expansion of AIDS virus-specific CTL. J Immunol 1996; 157: 3681.
    • (1996) J Immunol , vol.157 , pp. 3681
    • Kanai, T.1    Thomas, E.K.2    Yasutomi, Y.3    Letvin, N.L.4
  • 6
    • 0037306895 scopus 로고    scopus 로고
    • IL-15 enhances survival and function of HIV-specific CD8+ T cells
    • Mueller YM, Bojczuk PM, Halstead ES, et al. IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood 2003; 101: 1024.
    • (2003) Blood , vol.101 , pp. 1024
    • Mueller, Y.M.1    Bojczuk, P.M.2    Halstead, E.S.3
  • 7
    • 35148829883 scopus 로고    scopus 로고
    • Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects
    • Mueller YM, Petrovas C, Do DH, et al. Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects. J Virol 2007; 81: 10861.
    • (2007) J Virol , vol.81 , pp. 10861
    • Mueller, Y.M.1    Petrovas, C.2    Do, D.H.3
  • 8
    • 1642289250 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
    • Petrovas C, Mueller YM, Dimitriou ID, et al. HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL. J Immunol 2004; 172: 4444.
    • (2004) J Immunol , vol.172 , pp. 4444
    • Petrovas, C.1    Mueller, Y.M.2    Dimitriou, I.D.3
  • 9
    • 0029147357 scopus 로고
    • Cytokine interactions in human immunodeficiency virus-infected individuals: Roles of interleukin (IL)-2, IL-12, and IL-15
    • Seder RA, Grabstein KH, Berzofsky JA, McDyer JF. Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15. J Exp Med 1995; 182: 1067.
    • (1995) J Exp Med , vol.182 , pp. 1067
    • Seder, R.A.1    Grabstein, K.H.2    Berzofsky, J.A.3    McDyer, J.F.4
  • 10
    • 0037526584 scopus 로고    scopus 로고
    • Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: Regulation by interleukin (IL)-2, IL-15, and Bcl-2
    • Zaunders JJ, Moutouh-de Parseval L, Kitada S, et al. Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2. J Infect Dis 2003; 187: 1735.
    • (2003) J Infect Dis , vol.187 , pp. 1735
    • Zaunders, J.J.1    Moutouh-de Parseval, L.2    Kitada, S.3
  • 11
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, Norris PJ, Qin L, et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 2009; 83: 3719.
    • (2009) J Virol , vol.83 , pp. 3719
    • Stacey, A.R.1    Norris, P.J.2    Qin, L.3
  • 12
    • 20144387661 scopus 로고    scopus 로고
    • Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
    • Kornfeld C, Ploquin MJ, Pandrea I, et al. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 2005; 115: 1082.
    • (2005) J Clin Invest , vol.115 , pp. 1082
    • Kornfeld, C.1    Ploquin, M.J.2    Pandrea, I.3
  • 13
    • 63149109249 scopus 로고    scopus 로고
    • Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection
    • Eberly MD, Kader M, Hassan W, et al. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. J Immunol 2009; 182: 1439.
    • (2009) J Immunol , vol.182 , pp. 1439
    • Eberly, M.D.1    Kader, M.2    Hassan, W.3
  • 14
    • 40449100795 scopus 로고    scopus 로고
    • IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
    • Mueller YM, Do DH, Altork SR, et al. IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses. J Immunol 2008; 180: 350.
    • (2008) J Immunol , vol.180 , pp. 350
    • Mueller, Y.M.1    Do, D.H.2    Altork, S.R.3
  • 15
    • 67650457719 scopus 로고    scopus 로고
    • Profound CD4+/CCR5 + T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis
    • Okoye A, Park H, Rohankhedkar M, et al. Profound CD4+/CCR5 + T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med 2009; 206: 1575.
    • (2009) J Exp Med , vol.206 , pp. 1575
    • Okoye, A.1    Park, H.2    Rohankhedkar, M.3
  • 16
    • 0141724627 scopus 로고    scopus 로고
    • Levels of interleukin-15 in plasma may predict a favorable outcome of structured treatment interruption in patients with chronic human immunodeficiency virus infection
    • Amicosante M, Poccia F, Gioia C, et al. Levels of interleukin-15 in plasma may predict a favorable outcome of structured treatment interruption in patients with chronic human immunodeficiency virus infection. J Infect Dis 2003; 188: 661.
    • (2003) J Infect Dis , vol.188 , pp. 661
    • Amicosante, M.1    Poccia, F.2    Gioia, C.3
  • 17
    • 34247626328 scopus 로고    scopus 로고
    • Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment
    • Marcondes MC, Burdo TH, Sopper S, et al. Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment. J Immunol 2007; 178: 5812.
    • (2007) J Immunol , vol.178 , pp. 5812
    • Marcondes, M.C.1    Burdo, T.H.2    Sopper, S.3
  • 18
    • 34447322319 scopus 로고    scopus 로고
    • Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV- 1-infected subjects
    • Boulassel MR, Mercier F, Gilmore N, Routy JP. Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV- 1-infected subjects. Clin Immunol 2007; 124: 149.
    • (2007) Clin Immunol , vol.124 , pp. 149
    • Boulassel, M.R.1    Mercier, F.2    Gilmore, N.3    Routy, J.P.4
  • 19
    • 20144386847 scopus 로고    scopus 로고
    • Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques
    • Mueller YM, Petrovas C, Bojczuk PM, et al. Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. J Virol 2005; 79: 4877.
    • (2005) J Virol , vol.79 , pp. 4877
    • Mueller, Y.M.1    Petrovas, C.2    Bojczuk, P.M.3
  • 20
    • 33745202622 scopus 로고    scopus 로고
    • IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    • Picker LJ, Reed-Inderbitzin EF, Hagen SI, et al. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest 2006; 116: 1514.
    • (2006) J Clin Invest , vol.116 , pp. 1514
    • Picker, L.J.1    Reed-Inderbitzin, E.F.2    Hagen, S.I.3
  • 21
    • 33645924682 scopus 로고    scopus 로고
    • HIV disease: Fallout from a mucosal catastrophe?
    • Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006; 7: 235.
    • (2006) Nat Immunol , vol.7 , pp. 235
    • Brenchley, J.M.1    Price, D.A.2    Douek, D.C.3
  • 22
    • 33745363316 scopus 로고    scopus 로고
    • Immunopathogenesis of acute AIDS virus infection
    • Picker LJ. Immunopathogenesis of acute AIDS virus infection. Curr Opin Immunol 2006; 18: 399.
    • (2006) Curr Opin Immunol , vol.18 , pp. 399
    • Picker, L.J.1
  • 23
    • 3342897676 scopus 로고    scopus 로고
    • Interleukin-15: A new cytokine target for the treatment of inflammatory diseases
    • McInnes IB, Gracie JA. Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr Opin Pharmacol 2004; 4: 392.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 392
    • McInnes, I.B.1    Gracie, J.A.2
  • 24
    • 70350511426 scopus 로고    scopus 로고
    • Safety and immunologic effects of IL-15 administration in nonhuman primates
    • Berger C, Berger M, Hackman RC, et al. Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood 2009; 114: 2417.
    • (2009) Blood , vol.114 , pp. 2417
    • Berger, C.1    Berger, M.2    Hackman, R.C.3
  • 25
    • 3042548953 scopus 로고    scopus 로고
    • IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques
    • Villinger F, Miller R, Mori K, et al. IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques. Vaccine 2004; 22: 3510.
    • (2004) Vaccine , vol.22 , pp. 3510
    • Villinger, F.1    Miller, R.2    Mori, K.3
  • 26
    • 0028829105 scopus 로고
    • Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2
    • Munger W, DeJoy SQ, Jeyaseelan Sr R, et al. Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2. Cell Immunol 1995; 165: 289.
    • (1995) Cell Immunol , vol.165 , pp. 289
    • Munger, W.1    DeJoy, S.Q.2    Jeyaseelan Sr., R.3
  • 27
    • 0032943428 scopus 로고    scopus 로고
    • Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2
    • Lentsch AB, Miller FN, Edwards MJ. Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2. Cancer Immunol Immunother 1999; 47: 243.
    • (1999) Cancer Immunol Immunother , vol.47 , pp. 243
    • Lentsch, A.B.1    Miller, F.N.2    Edwards, M.J.3
  • 29
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997; 277: 112.
    • (1997) Science , vol.277 , pp. 112
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 30
    • 0034687071 scopus 로고    scopus 로고
    • Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy
    • Grabar S, Le Moing V, Goujard C, et al. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann Intern Med 2000; 133: 401.
    • (2000) Ann Intern Med , vol.133 , pp. 401
    • Grabar, S.1    Le Moing, V.2    Goujard, C.3
  • 31
    • 59649116097 scopus 로고    scopus 로고
    • IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment
    • Leone A, Picker LJ, Sodora DL. IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment. Curr HIV Res 2009; 7: 83.
    • (2009) Curr HIV Res , vol.7 , pp. 83
    • Leone, A.1    Picker, L.J.2    Sodora, D.L.3
  • 32
    • 70350441282 scopus 로고    scopus 로고
    • Interleukin-2 therapy in patients with HIV infection
    • Abrams D, Levy Y, Losso MH, et al. Interleukin-2 therapy in patients with HIV infection. N Engl J Med 2009; 361: 1548.
    • (2009) N Engl J Med , vol.361 , pp. 1548
    • Abrams, D.1    Levy, Y.2    Losso, M.H.3
  • 33
    • 11144353584 scopus 로고    scopus 로고
    • Induction and maintenance therapy with intermittent interleukin-2 in HIV-1 infection
    • Farel CE, Chaitt DG, Hahn BK, et al. Induction and maintenance therapy with intermittent interleukin-2 in HIV-1 infection. Blood 2004; 103: 3282.
    • (2004) Blood , vol.103 , pp. 3282
    • Farel, C.E.1    Chaitt, D.G.2    Hahn, B.K.3
  • 34
    • 22144470799 scopus 로고    scopus 로고
    • In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients
    • Sereti I, Imamichi H, Natarajan V, et al. In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients. J Clin Invest 2005; 115: 1839.
    • (2005) J Clin Invest , vol.115 , pp. 1839
    • Sereti, I.1    Imamichi, H.2    Natarajan, V.3
  • 35
    • 0037105607 scopus 로고    scopus 로고
    • Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: Characterization of a novel subset of CD4(+)/CD25(+) T cells
    • Sereti I, Martinez-Wilson H, Metcalf JA, et al. Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells. Blood 2002; 100: 2159.
    • (2002) Blood , vol.100 , pp. 2159
    • Sereti, I.1    Martinez-Wilson, H.2    Metcalf, J.A.3


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