The SV2 variant of KLF6 is down-regulated in hepatocellular carcinoma and displays anti-proliferative and pro-apoptotic functions

Journal of Hepatology

Volumn 53, Issue 5, 2010, Pages 880-888

  Hanoun, Naïma ^a,b   Bureau, Christophe ^a,b,c   Diab, Thoria ^a,b   Gayet, Odile ^a,d   Dusetti, Nelson ^a,d   Selves, Janick ^a,b,c   Vinel, Jean Pierre ^a,b,c   Buscail, Louis ^a,b,e   Cordelier, Pierre ^a,b   Torrisani, Jérôme ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c CHU PURPAN   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Apoptosis; Cell proliferation; Hepatocellular carcinoma; Kr ppel like factor 6; p53 Protein; Splice variant

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GEMCITABINE; KRUPPEL LIKE FACTOR 6; PROTEIN BAX; PROTEIN SV2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DEOXYCYTIDINE; DOWN-REGULATION; HEP G2 CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER NEOPLASMS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957326321     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.038     Document Type: Article

References (20)

1. A.R. Black, J.D. Black, and J. Azizkhan-Clifford Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer J Cell Physiol 188 2001 143 160
2. G. Narla, K.E. Heath, H.L. Reeves, D. Li, L.E. Giono, and A.C. Kimmelman KLF6, a candidate tumor suppressor gene mutated in prostate cancer Science 294 2001 2563 2566
3. H.L. Reeves, G. Narla, O. Ogunbiyi, A.I. Haq, A. Katz, and S. Benzeno Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer Gastroenterology 126 2004 1090 1103
4. S. Kremer-Tal, H.L. Reeves, G. Narla, S.N. Thung, M. Schwartz, and A. Difeo Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma Hepatology 40 2004 1047 1052
5. E. Sirach, C. Bureau, J.M. Peron, L. Pradayrol, J.P. Vinel, and L. Buscail KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis Cell Death Differ 14 2007 1202 1210
6. S. Boyault, A. Herault, C. Balabaud, and J. Zucman-Rossi Absence of KLF6 gene mutation in 71 hepatocellular carcinomas Hepatology 41 2005 681 682 author reply 682 - 3
7. K.R. Muhlbauer, H.J. Grone, T. Ernst, E. Grone, R. Tschada, and M. Hergenhahn Analysis of human prostate cancers and cell lines for mutations in the TP53 and KLF6 tumour suppressor genes Br J Cancer 89 2003 687 690
8. A. Lievre, B. Landi, J.F. Cote, N. Veyrie, J. Zucman-Rossi, and A. Berger Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers Oncogene 24 2005 7253 7256 (Pubitemid 41679287)
9. G. Narla, A. Difeo, H.L. Reeves, D.J. Schaid, J. Hirshfeld, and E. Hod A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk Cancer Res 65 2005 1213 1222
10. G. Narla, A. DiFeo, Y. Fernandez, S. Dhanasekaran, F. Huang, and J. Sangodkar KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis J Clin Invest 118 2008 2711 2721
11. S. Yea, G. Narla, X. Zhao, R. Garg, S. Tal-Kremer, and E. Hod Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma Gastroenterology 134 2008 1521 1531
12. S. Kremer-Tal, G. Narla, Y. Chen, E. Hod, A. DiFeo, and S. Yea Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation J Hepatol 46 2007 645 654
13. A. Olsson, C. Manzl, A. Strasser, and A. Villunger How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? Cell Death Differ 14 2007 1561 1575
14. C. Bureau, J.M. Peron, M. Bouisson, M. Danjoux, J. Selves, and P. Bioulac-Sage Expression of the transcription factor Klf6 in cirrhosis, macronodules, and hepatocellular carcinoma J Gastroenterol Hepatol 23 2008 78 86
15. L. Miele, G. Beale, G. Patman, V. Nobili, J. Leathart, and A. Grieco The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease Gastroenterology 135 2008 282 291 e1
16. B. Vogelstein, D. Lane, and A.J. Levine Surfing the p53 network Nature 408 2000 307 310
17. M. Rubinstein, G. Idelman, S.R. Plymate, G. Narla, S.L. Friedman, and H. Werner Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53 Endocrinology 145 2004 3769 3777
18. U. Vijapurkar, W. Wang, and R. Herbst Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways Cancer Res 67 2007 237 245
19. G. Achanta, H. Pelicano, L. Feng, W. Plunkett, and P. Huang Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage Cancer Res 61 2001 8723 8729
20. M. Chen, A.M. Hough, and T.S. Lawrence The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization Cancer Chemother Pharmacol 45 2000 369 374