Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 28, 2010, Pages 2751-2759

  Sparidans, Rolf W ^a   Iusuf, Dilek ^b   Schinkel, Alfred H ^b   Schellens, Jan H M ^a,b   Beijnen, Jos H ^a,b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

3 Isopravastatin; 6 Epipravastatin; LC MS MS; Mouse tissue homogenate; Plasma; Pravastatin

Indexed keywords

ANALYTES; ANALYTICAL CONDITIONS; BIOANALYTICAL ASSAYS; CHROMATOGRAPHIC SYSTEMS; CONCENTRATION RANGES; ELECTROSPRAY INTERFACES; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; ISOCRATIC ELUTION; ISOMERIC COMPOUNDS; LC/MS/MS; MOUSE PLASMA; MOUSE TISSUES; OCTADECYL SILICA; PILOT STUDIES; PLASMA SAMPLES; PRAVASTATIN; PROTEIN PRECIPITATION; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRIC; TISSUE HOMOGENATES; TRIPLE-QUADRUPOLE MASS SPECTROMETER; WATER-ACETONITRILE MIXTURES;

ACETONITRILE; BIOMOLECULES; DEUTERIUM; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC ACIDS; SILICA; SOLVENT EXTRACTION; TISSUE;

PLASMAS;

3' ALPHA ISOPRAVASTATIN; 6' EPIPRAVASTATIN; DRUG METABOLITE; PRAVASTATIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUSE; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATE;

ANIMALS; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; KIDNEY; LIVER; MALE; MICE; MYOCARDIUM; PRAVASTATIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

MUS;

EID: 77957316526     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.08.015     Document Type: Article

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