An automated method for the simultaneous determination of pravastatin and its main metabolite in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Biomedical Chromatography

Volumn 12, Issue 5, 1998, Pages 271-275

  Kawabata, Kiyoshi ^a   Matsushima, Nobuko ^a   Sasahara, Kunihiro ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACTION; GAS CHROMATOGRAPHY; IONIZATION OF GASES; MASS SPECTROMETRY; METABOLITES; NEGATIVE IONS; PHASE SEPARATION; PLASMA (HUMAN);

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY; AUTOMATED METHODS; CHEMICAL IONIZATION MASS SPECTROMETRY; COENZYME A; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN PLASMAS; NEGATIVE ION CHEMICAL IONIZATION; POTENT INHIBITOR; PRAVASTATIN; SIMULTANEOUS DETERMINATIONS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

DRUG METABOLITE; PRAVASTATIN;

ARTICLE; AUTOANALYSIS; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; ION MONITORING; MASS SPECTROMETRY; SOLID PHASE EXTRACTION;

EID: 0031717471     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0801(199809/10)12:5<271::AID-BMC746>3.0.CO;2-F     Document Type: Article

References (4)

1. Funke, P. T., Ivashkiv, E., Arnold, M. E. and Cohen, A. I. (1989). Biomed. Environ. Mass. Spectrom. 18, 904.
2. Kawabata, K. and Sasahara, K. (1991). Proc. Jap. Soc. Biomed. Mass Spectrom. 16, 149.
3. Morris, M. J., Gilbert, J. D., Hsieh, J. Y., Matuszewski, B. K., Ramjit, H. G. and Bayne, W. F. (1993). Biol. Mass. Spectrom. 22, 1.
4. Whigan, D. B., Ivashkiv, E. and Cohen, A. I. (1989). J. Pharm. Biomed. Anal. 7, 907.