Improved pH-independent dissolution and oral absorption of valsartan via the preparation of solid dispersion

Archives of Pharmacal Research

Volumn 33, Issue 8, 2010, Pages 1235-1240

  Park, Young Joon ^a   Lee, Hyoung Kyu ^b   Im, Young Bin ^a,b   Lee, Wonjae ^b   Han, Hyo Kyung ^b  

^a Samil Pharmaceutical Co Ltd   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Absorption; Dissolution; Poloxamer 407; Solid dispersion; Valsartan

Indexed keywords

POLOXAMER; VALSARTAN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH MEASUREMENT; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; MALE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; TETRAZOLES; VALINE;

EID: 77957313944     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0814-0     Document Type: Article

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