Physicochemical properties of valsartan and the effect of ethyl alcohol, propylene glycol and pH on its solubility

Pharmazie

Volumn 60, Issue 11, 2005, Pages 849-850

  Mbah, C J ^a  

^a DMI Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; PROPYLENE GLYCOL; SOLVENT; VALSARTAN; WATER;

ARTICLE; DOSE RESPONSE; DRUG SOLUBILITY; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; ROOM TEMPERATURE; THERMODYNAMICS;

ANTIHYPERTENSIVE AGENTS; CALIBRATION; CHEMISTRY, PHYSICAL; ETHANOL; HYDROGEN-ION CONCENTRATION; PROPYLENE GLYCOL; REFERENCE STANDARDS; SOLUBILITY; SOLVENTS; TETRAZOLES; THERMODYNAMICS; VALINE;

EID: 28244444534     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Breon TL, Paruta AN (1970) Solubility profiles for several barbiturates in hydroalcoholic mixtures. J Pharm Sci 59: 1306-1313.
2. Feldman S, Gibaldi M (1967) Effect of urea on solubility. Role of water structure. J Pharm Sci 56: 370-375.
3. Latif F, Tandon S, Obeleniene R, Hankins SR, Berlowitz MS, Ennezat PV, Le Jemtel TH (2001) Angiotensin II type 1 receptor blockade with 80 and 160 mg valsartan in healthy, normotensive subjects. J Card Fail 7: 265-268.
4. Li P, Tabibi SE, Yalkowsky SH (1999) Solubilization of ionized and unionized flavopiridol by ethanol and polysorbate 20. J Pharm Sci 88: 507-509.
5. Varia SA, Faustino MM, Thakur AB, Clow CS, Serajuddin AT (1991) Optimization of cosolvent concentration and excipient composition in a topical corticosteroid solution. J Pharm Sci 80: 872-875.
6. Yalkowsky SH, Rubino JT (1985) Solubilization of cosolvents 1: Organic solutes in propylene glycol-water mixtures. J Pharm Sci 74: 416-421.