Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 4, 2008, Pages 569-574

  Newa, Madhuri ^a   Bhandari, Krishna Hari ^a   Kim, Jong Oh ^a   Im, Jong Seob ^a   Kim, Jung Ae ^a   Yoo, Bong Kyu ^a   Woo, Jong Soo ^a   Choi, Han Gon ^a   Yong, Chul Soon ^a  

^a Yeungnam University   (South Korea)

Author keywords

Bioavailability; Dissolution; Ibuprofen; Polyethylene glycol 8000; Solid dispersion; Solubility

Indexed keywords

IBUPROFEN; MACROGOL 8000;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; POWDER; RAT; SCANNING ELECTRON MICROSCOPE; SURFACE PROPERTY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; IBUPROFEN; MALE; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 42049110119     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.569     Document Type: Article

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