Cellular reprogramming of human amniotic fluid cells to express insulin

Differentiation

Volumn 80, Issue 2-3, 2010, Pages 130-139

  Gage, Blair K ^a   Riedel, Michael J ^a   Karanu, Francis ^b   Rezania, Alireza ^b   Fujita, Yukihiro ^a,c   Webber, Travis D ^a   Baker, Robert K ^a   Wideman, Rhonda D ^a   Kieffer, Timothy J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BetaLogics Venture   (United States)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Amniotic fluid cells; Fluorescent reporter; High content screening; Insulin; Reprogramming; Transcription factors

Indexed keywords

GLUCOSE; INSULIN; LENTIVIRUS VECTOR; TRANSCRIPTION FACTOR;

AMNIOTIC FLUID CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; EMBRYONIC STEM CELL; FLOW CYTOMETRY; GENE ACTIVATION; GENE EXPRESSION; GERM LAYER; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN METABOLISM; KIDNEY TRANSPLANTATION; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION;

ADENOVIRIDAE; AMNIOTIC FLUID; ANIMALS; CELLS, CULTURED; FLOW CYTOMETRY; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; PROMOTER REGIONS, GENETIC; RATS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 77957303675     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2010.05.007     Document Type: Article

References (26)

1. Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W., Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B., Brooking J., Chen K.G., Choo A.B., Churchill G.A., Corbel M., Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A., Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S., Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P., Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K., King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D., Mayshar Y., McKay R.D., Michalska A.E., Mikkola M., Mileikovsky M., Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N., O'Brien C.M., Oh S.K., Olsson C., Otonkoski T., Park K.Y., Passier R., Patel H., Patel M., Pedersen R., Pera M.F., Piekarczyk M.S., Pera R.A., Reubinoff B.E., Robins A.J., Rossant J., Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H., Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T., Tuuri T., van den Brink S., Vintersten K., Vuoristo S., Ward D., Weaver T.A., Young L.A., Zhang W. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat. Biotechnol. 2007, 25:803-816.
2. Baum C.M., Weissman I.L., Tsukamoto A.S., Buckle A.M., Peault B. Isolation of a candidate human hematopoietic stem-cell population. Proc. Natl. Acad. Sci. USA 1992, 89:2804-2808.
3. Ber I., Shternhall K., Perl S., Ohanuna Z., Goldberg I., Barshack I., Benvenisti-Zarum L., Meivar-Levy I., Ferber S. Functional, persistent, and extended liver to pancreas transdifferentiation. J. Biol. Chem. 2003, 278:31950-31957.
4. D'Amour K.A., Agulnick A.D., Eliazer S., Kelly O.G., Kroon E., Baetge E.E. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 2005, 23:1534-1541.
5. D'Amour K.A., Bang A.G., Eliazer S., Kelly O.G., Agulnick A.D., Smart N.G., Moorman M.A., Kroon E., Carpenter M.K., Baetge E.E. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 2006, 24:1392-1401.
6. De Coppi P., Bartsch G., Siddiqui M.M., Xu T., Santos C.C., Perin L., Mostoslavsky G., Serre A.C., Snyder E.Y., Yoo J.J., Furth M.E., Soker S., Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat. Biotechnol. 2007, 25:100-106.
7. Gargett C.E. Identification and characterisation of human endometrial stem/progenitor cells. Aust. NZ. J. Obstet. Gynaecol. 2006, 46:250-253.
8. Gruessner A.C., Sutherland D.E. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). Clin. Transplant. 2008, 45-56.
9. Hou Y., Huang Q., Liu T., Guo L. Human amnion epithelial cells can be induced to differentiate into functional insulin-producing cells. Acta Biochim. Biophys. Sin. (Shanghai) 2008, 40:830-839.
10. In't Anker P.S., Scherjon S.A., Kleijburg-van der Keur C., Noort W.A., Claas F.H., Willemze R., Fibbe W.E., Kanhai H.H. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003, 102:1548-1549.
11. Jin T. Mechanisms underlying proglucagon gene expression. J. Endocrinol. 2008, 198:17-28.
12. King A.J., Fernandes J.R., Hollister-Lock J., Nienaber C.E., Bonner-Weir S., Weir G.C. Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes 2007, 56:2312-2318.
13. Kojima H., Fujimiya M., Matsumura K., Younan P., Imaeda H., Maeda M., Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med. 2003, 9:596-603.
14. Kroon E., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D'Amour K.A., Carpenter M.K., Baetge E.E. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 2008, 26:443-452.
15. Li Y., Zhang R., Qiao H., Zhang H., Wang Y., Yuan H., Liu Q., Liu D., Chen L., Pei X. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J. Cell Physiol. 2007, 211:36-44.
16. Masson N.M., Currie I.S., Terrace J.D., Garden O.J., Parks R.W., Ross J.A. Hepatic progenitor cells in human fetal liver express the oval cell marker Thy-1. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 291:G45-G54.
17. Mombaerts P., Iacomini J., Johnson R.S., Herrup K., Tonegawa S., Papaioannou V.E. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992, 68:869-877.
18. Naya F.J., Stellrecht C.M., Tsai M.J. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 1995, 9:1009-1019.
19. Ohlsson H., Karlsson K., Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 1993, 12:4251-4259.
20. Olbrot M., Rud J., Moss L.G., Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc. Natl. Acad. Sci. USA 2002, 99:6737-6742.
21. Oliver-Krasinski J.M., Stoffers D.A. On the origin of the beta cell. Genes Dev. 2008, 22:1998-2021.
22. Shapiro A.M., Lakey J.R., Ryan E.A., Korbutt G.S., Toth E., Warnock G.L., Kneteman N.M., Rajotte R.V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 2000, 343:230-238.
23. Wei J.P., Zhang T.S., Kawa S., Aizawa T., Ota M., Akaike T., Kato K., Konishi I., Nikaido T. Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice. Cell Transplant. 2003, 12:545-552.
24. Xu C., Inokuma M.S., Denham J., Golds K., Kundu P., Gold J.D., Carpenter M.K. Feeder-free growth of undifferentiated human embryonic stem cells. Nat. Biotechnol. 2001, 19:971-974.
25. Zhang H., Wang W.P., Guo T., Yang J.C., Chen P., Ma K.T., Guan Y.F., Zhou C.Y. The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2. J. Mol. Biol. 2009, 392:566-577.
26. Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., Melton, D.A., 2008. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632.