The immune signaling molecule 4-1BB stimulation reduces adiposity, insulin resistance, and hepatosteatosis in obese mice

Endocrinology

Volumn 151, Issue 10, 2010, Pages 4725-4735

  Kim, Chu Sook ^a   Tu, Thai Hien ^a   Kawada, Teruo ^b   Kim, Byung Sam ^a   Yu, Rina ^a  

^a University of Ulsan   (South Korea)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD 137 ANTIBODY; CD137 ANTIGEN; CHEMOKINE; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY; CD137 LIGAND;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL INFILTRATION; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY EXPENDITURE; FATTY ACID OXIDATION; FATTY LIVER; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLYCOLYSIS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; WEIGHT REDUCTION; AGONISTS; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; EVALUATION STUDY; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

4-1BB LIGAND; ADIPOSITY; ANIMALS; ANTIBODIES; CD8-POSITIVE T-LYMPHOCYTES; FATTY LIVER; GLUCOSE INTOLERANCE; IMMUNOTHERAPY; INSULIN RESISTANCE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; SIGNAL TRANSDUCTION;

EID: 77957272882     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0346     Document Type: Article

References (42)

1. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW 2003 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
2. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H 2003 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
3. Yu R, Kim CS, Kwon BS, Kawada T 2006 Mesenteric adipose tissuederived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring) 14:1353-1362
4. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R 2009 CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15:914-920
5. Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, Maezawa Y, Drucker DJ, Engleman E, Winer D, Dosch HM 2009 Normalization of obesityassociated insulin resistance through immunotherapy. Nat Med 15:921-929
6. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D 2009 Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15:930-939
7. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
8. Shoelson SE, Lee J, Goldfine AB 2006 Inflammation and insulin resistance. J Clin Invest 116:1793-1801
9. Watts TH 2005 TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23:23-68
10. Seo SK, Choi JH, Kim YH, Kang WJ, Park HY, Suh JH, Choi BK, Vinay DS, Kwon BS 2004 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10:1088-1094
11. Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX 2002 Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168:1457-1465
12. Fox CJ, Hammerman PS, Thompson CB 2005 Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 5:844-852
13. Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D, Spencer T, Dillehay D, Kwon B, Chen L, Vella AT, Mittler RS 2007 Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J Immunol 178:4194-4213
14. Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, Desimone C, Song XY, Diehl AM 2003 Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37:343-350
15. Frayn KN 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634
16. Lynch DH 2008 The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol Rev 222:277-286
17. Frauwirth KA, Thompson CB 2004 Regulation of T lymphocyte metabolism. J Immunol 172:4661-4665
18. Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS 1997 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47-55
19. Lee HW, Park SJ, Choi BK, Kim HH, Nam KO, Kwon BS 2002 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J Immunol 169:4882-4888
20. Lee SW, Salek-Ardakani S, Mittler RS, Croft M 2009 Hypercostimulation through 4-1BB distorts homeostasis of immune cells. J Immunol 182:6753-6762
21. Warburg O 1956 On respiratory impairment in cancer cells. Science 124:269-270
22. Vander Heiden MG, Cantley LC, Thompson CB 2009 Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033
23. Brand K 1985 Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism. Biochem J 228:353-361
24. Wang T, Marquardt C, Foker J 1976 Aerobic glycolysis during lymphocyte proliferation. Nature 261:702-705
25. Greiner EF, Guppy M, Brand K 1994 Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem 269:31484-31490
26. Roos D, Loos JA 1973 Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation. Exp Cell Res 77:127-135
27. Holroyde CP, Gabuzda TG, Putnam RC, Paul P, Reichard GA 1975 Altered glucose metabolism in metastatic carcinoma. Cancer Res 35:3710-3714
28. Hardie DG, Carling D 1997 The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246:259-273
29. Blázquez C, Woods A, de Ceballos ML, Carling D, Guzmán M 1999 The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J Neurochem 73:1674-1682
30. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF 2001 Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010
31. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T 2002 Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288-1295
32. Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ 2003 Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52:1355-1363
33. MemonRA, Feingold KR, Moser AH, DoerrlerW,GrunfeldC1992 In vivo effects of interferon-α and interferon-γ on lipolysis and ketogenesis. Endocrinology 131:1695-1702
34. McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP 2009 Interferon γ attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem 284: 31936-31944
35. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH 2008 Adipocyte-derived Th2 cytokines and myeloid PPARΔ regulate macrophage polarization and insulin sensitivity. Cell Metab 7:485-495
36. Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, Friedline RH, Kurt-Jones E, Finberg R, Fischer MA, Granger EL, Norbury CC, Hauschka SD, Philbrick WM, Lee CG, Elias JA, Kim JK 2009 Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes 58: 2525-2535
37. Cintra DE, Pauli JR, Araújo EP, Moraes JC, de Souza CT, Milanski M, Morari J, Gambero A, Saad MJ, Velloso LA 2008 Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol 48:628-637
38. Yamauchi T, Hara K, Kubota N, Terauchi Y, Tobe K, Froguel P, Nagai R, Kadowaki T 2003 Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr Drug Targets Immune Endocr Metab Disord 3:243-254
39. Hu X, Ivashkiv LB 2009 Cross-regulation of signaling pathways by interferon-γ: implications for immune responses and autoimmune diseases. Immunity 31:539-550
40. Ju SA, Lee SC, Kwon TH, Heo SK, Park SM, Paek HN, Suh JH, Cho HR, Kwon B, Kwon BS, Kim BS 2005 Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumourinfiltrating lymphocytes. Immunol Cell Biol 83:344-351
41. Ju SA, Park SM, Lee SC, Kwon BS, Kim BS 2007 Marked expansion of CD11c+CD8+ T-cells in melanoma-bearing mice induced by anti-4-1BB monoclonal antibody. Mol Cells 24:132-138
42. Lee SW, Croft M 2009 4-1BB as a therapeutic target for human disease. Adv Exp Med Biol 647:120-129