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Volumn 122, Issue 4, 2010, Pages 295-301

A useful cell system for studying the regulation of 17HSD/KSR type 2 activity and expression in ovarian epithelial cancer

Author keywords

17 Hydroxysteroid dehydrogenase type 1; 17 Hydroxysteroid dehydrogenase type 2; 17 Hydroxysteroid dehydrogenase type 4; 17 Hydroxysteroid dehydrogenase type 5; Ovarian cancer cells

Indexed keywords

17 HYDROXYSTEROID DEHYDROGENASE; ANDROSTERONE; MESSENGER RNA; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 1; TESTOSTERONE 17BETA DEHYDROGENASE 2; TESTOSTERONE 17BETA DEHYDROGENASE 4; TESTOSTERONE 17BETA DEHYDROGENASE 5; UNCLASSIFIED DRUG; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; HYDROXYSTEROID DEHYDROGENASE;

EID: 77957271811     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.06.008     Document Type: Article
Times cited : (3)

References (54)
  • 2
  • 4
    • 34548118366 scopus 로고    scopus 로고
    • Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    • Walker G., MacLeod K., Williams A.R., Cameron D.A., Smyth J.F., Langdon S.P. Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Gynecol. Oncol. 2007, 106:461-468.
    • (2007) Gynecol. Oncol. , vol.106 , pp. 461-468
    • Walker, G.1    MacLeod, K.2    Williams, A.R.3    Cameron, D.A.4    Smyth, J.F.5    Langdon, S.P.6
  • 5
    • 0030925341 scopus 로고    scopus 로고
    • Molecular endocrinology of hydroxysteroid dehydrogenases
    • Penning T.M. Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr. Rev. 1997, 18:281-305.
    • (1997) Endocr. Rev. , vol.18 , pp. 281-305
    • Penning, T.M.1
  • 6
    • 61649096847 scopus 로고    scopus 로고
    • Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease
    • Meier M., Moller G., Adamski J. Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease. Ann. N.Y. Acad. Sci. 2009, 1155:15-24.
    • (2009) Ann. N.Y. Acad. Sci. , vol.1155 , pp. 15-24
    • Meier, M.1    Moller, G.2    Adamski, J.3
  • 10
    • 0029437995 scopus 로고
    • Pathology of ovarian cancer precursors
    • Scully R.E. Pathology of ovarian cancer precursors. J. Cell. Biochem. 1995, 23:208-218.
    • (1995) J. Cell. Biochem. , vol.23 , pp. 208-218
    • Scully, R.E.1
  • 12
    • 0026032112 scopus 로고
    • Endocrine factors in common epithelial ovarian cancer
    • Rao B.R., Slotman B.J. Endocrine factors in common epithelial ovarian cancer. Endocr. Rev. 1991, 12:14-26.
    • (1991) Endocr. Rev. , vol.12 , pp. 14-26
    • Rao, B.R.1    Slotman, B.J.2
  • 13
    • 0032477328 scopus 로고    scopus 로고
    • Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
    • Risch H.A. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J. Natl. Cancer Inst. 1998, 90:1774-1786.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1774-1786
    • Risch, H.A.1
  • 14
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: biology, endocrinology, and pathology
    • Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 2001, 22:255-288.
    • (2001) Endocr. Rev. , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3    Kang, S.K.4    Leung, P.C.5
  • 15
    • 12344334475 scopus 로고    scopus 로고
    • Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis
    • Rae M.T., Niven D., Ross A., Forster T., Lathe R., Critchley H.O., Ghazal P., Hillier S.G. Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. J. Endocrinol. 2004, 183:19-28.
    • (2004) J. Endocrinol. , vol.183 , pp. 19-28
    • Rae, M.T.1    Niven, D.2    Ross, A.3    Forster, T.4    Lathe, R.5    Critchley, H.O.6    Ghazal, P.7    Hillier, S.G.8
  • 16
    • 0022447530 scopus 로고
    • Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors
    • Heinonen P.K., Koivula T., Rajaniemi H., Pystynen P. Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors. Gynecol. Oncol. 1986, 25:1-10.
    • (1986) Gynecol. Oncol. , vol.25 , pp. 1-10
    • Heinonen, P.K.1    Koivula, T.2    Rajaniemi, H.3    Pystynen, P.4
  • 17
    • 24044488286 scopus 로고    scopus 로고
    • Steroid signalling in the ovarian surface epithelium
    • Rae M.T., Hillier S.G. Steroid signalling in the ovarian surface epithelium. Trends Endocrinol. Metab. 2005, 16:327-333.
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 327-333
    • Rae, M.T.1    Hillier, S.G.2
  • 18
    • 0029589781 scopus 로고
    • Properties and regulation of 17 beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone
    • Blomquist C.H., Leung B.S., Zhang R.P., Zhu Y.Y., Chang P.M. Properties and regulation of 17 beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone. J. Cell. Biochem. 1995, 59:409-417.
    • (1995) J. Cell. Biochem. , vol.59 , pp. 409-417
    • Blomquist, C.H.1    Leung, B.S.2    Zhang, R.P.3    Zhu, Y.Y.4    Chang, P.M.5
  • 19
    • 0036668766 scopus 로고    scopus 로고
    • Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms
    • Blomquist C.H., Bonenfant M., McGinley D.M., Posalaky Z., Lakatua D.J., Tuli-Puri S., Bealka D.G., Tremblay Y. Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms. J. Steroid Biochem. Mol. Biol. 2002, 81:343-351.
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.81 , pp. 343-351
    • Blomquist, C.H.1    Bonenfant, M.2    McGinley, D.M.3    Posalaky, Z.4    Lakatua, D.J.5    Tuli-Puri, S.6    Bealka, D.G.7    Tremblay, Y.8
  • 22
    • 0028116927 scopus 로고
    • Primary cultures of normal and tumoral human ovarian epithelium: a powerful tool for basic molecular studies
    • Lounis H., Provencher D., Godbout C., Fink D., Milot M.J., Mes-Masson A.M. Primary cultures of normal and tumoral human ovarian epithelium: a powerful tool for basic molecular studies. Exp. Cell Res. 1994, 215:303-309.
    • (1994) Exp. Cell Res. , vol.215 , pp. 303-309
    • Lounis, H.1    Provencher, D.2    Godbout, C.3    Fink, D.4    Milot, M.J.5    Mes-Masson, A.M.6
  • 23
    • 0029620941 scopus 로고
    • Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase
    • Blomquist C.H. Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase. J. Steroid Biochem. Mol. Biol. 1995, 55:515-524.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.55 , pp. 515-524
    • Blomquist, C.H.1
  • 24
    • 0034464033 scopus 로고    scopus 로고
    • Androgen formation and metabolism in the pulmonary epithelial cell line A-549: expression of 17β-hydroxysteroid dehydrogenase type 5 and 3α-hydroxysteroid dehydrogenase type 3
    • Provost P.R., Blomquist C.H., Godin C., Huang X.-F., Flamand N., Luu-The V., Nadeau D., Tremblay Y. Androgen formation and metabolism in the pulmonary epithelial cell line A-549: expression of 17β-hydroxysteroid dehydrogenase type 5 and 3α-hydroxysteroid dehydrogenase type 3. Endocrinology 2000, 141:2786-2794.
    • (2000) Endocrinology , vol.141 , pp. 2786-2794
    • Provost, P.R.1    Blomquist, C.H.2    Godin, C.3    Huang, X.-F.4    Flamand, N.5    Luu-The, V.6    Nadeau, D.7    Tremblay, Y.8
  • 25
    • 0024261556 scopus 로고
    • Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice
    • Tremblay Y., Tretjakoff I., Peterson A., Antakly T., Zhang C.X., Drouin J. Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:8890-8894.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 8890-8894
    • Tremblay, Y.1    Tretjakoff, I.2    Peterson, A.3    Antakly, T.4    Zhang, C.X.5    Drouin, J.6
  • 27
    • 0028980150 scopus 로고
    • Gene expression of 17β-hydroxysteroid dehydrogenase type 2 isozyme in primary cultures of human trophoblasts predicts different mechanisms regulating type 1 and type 2 enzymes
    • Beaudoin C., Blomquist C.H., Tremblay Y. Gene expression of 17β-hydroxysteroid dehydrogenase type 2 isozyme in primary cultures of human trophoblasts predicts different mechanisms regulating type 1 and type 2 enzymes. Endocrinology 1995, 136:3807-3814.
    • (1995) Endocrinology , vol.136 , pp. 3807-3814
    • Beaudoin, C.1    Blomquist, C.H.2    Tremblay, Y.3
  • 28
    • 0034730758 scopus 로고    scopus 로고
    • Length increase of the human alpha-globin 3′-untranslated region disrupts stability of the pre-mRNA but not that of the mature mRNA
    • Provost P., Tremblay Y. Length increase of the human alpha-globin 3′-untranslated region disrupts stability of the pre-mRNA but not that of the mature mRNA. J. Biol. Chem. 2000, 275:30248-30255.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30248-30255
    • Provost, P.1    Tremblay, Y.2
  • 30
    • 0020793569 scopus 로고
    • A technique for radiolabelling DNA restriction endonuclease fragments
    • Feinberg A.P., Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments. Anal. Biochem. 1983, 132:6-13.
    • (1983) Anal. Biochem. , vol.132 , pp. 6-13
    • Feinberg, A.P.1    Vogelstein, B.2
  • 31
    • 3242771198 scopus 로고    scopus 로고
    • A link between lung androgen metabolism and the emergence of mature epithelial type II cells
    • Provost P.R., Simard M., Tremblay Y. A link between lung androgen metabolism and the emergence of mature epithelial type II cells. Am. J. Respir. Crit. Care Med. 2004, 170:296-305.
    • (2004) Am. J. Respir. Crit. Care Med. , vol.170 , pp. 296-305
    • Provost, P.R.1    Simard, M.2    Tremblay, Y.3
  • 32
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3. RESEARCH0034.
    • (2002) Genome Biol. , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 33
    • 34548063998 scopus 로고    scopus 로고
    • Human type 2 17beta-hydroxysteroid dehydrogenase mRNA and protein distribution in placental villi at mid and term pregnancy
    • Drolet R., Simard M., Plante J., Laberge P., Tremblay Y. Human type 2 17beta-hydroxysteroid dehydrogenase mRNA and protein distribution in placental villi at mid and term pregnancy. Reprod. Biol. Endocrinol. 2007, 5:30.
    • (2007) Reprod. Biol. Endocrinol. , vol.5 , pp. 30
    • Drolet, R.1    Simard, M.2    Plante, J.3    Laberge, P.4    Tremblay, Y.5
  • 34
    • 9944264069 scopus 로고    scopus 로고
    • Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha HSD/type 5 17betaHSD); immunohistochemical detection in breast and prostate
    • Lin H.-K., Steckelbroeck S., Fung K.-M., Jones A.N., Penning T.H. Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha HSD/type 5 17betaHSD); immunohistochemical detection in breast and prostate. Steroids 2004, 69:795-801.
    • (2004) Steroids , vol.69 , pp. 795-801
    • Lin, H.-K.1    Steckelbroeck, S.2    Fung, K.-M.3    Jones, A.N.4    Penning, T.H.5
  • 35
    • 0027225486 scopus 로고
    • Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity
    • Wu L., Einstein M., Geissler W.M., Chan H.K., Elliston O., Andersson S. Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J. Biol. Chem. 1993, 268:12964-12969.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12964-12969
    • Wu, L.1    Einstein, M.2    Geissler, W.M.3    Chan, H.K.4    Elliston, O.5    Andersson, S.6
  • 36
    • 0036342526 scopus 로고    scopus 로고
    • Androgen inactivation in human lung fibroblasts: variations in levels of 17β-hydroxysteroid dehydrogenase type 2 and 5α-reductase activity compatible with androgen inactivation
    • Provost P.R., Blomquist C.H., Drolet R., Flamand N., Tremblay Y. Androgen inactivation in human lung fibroblasts: variations in levels of 17β-hydroxysteroid dehydrogenase type 2 and 5α-reductase activity compatible with androgen inactivation. J. Clin. Endocrinol. Metab. 2002, 87:3883-3892.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3883-3892
    • Provost, P.R.1    Blomquist, C.H.2    Drolet, R.3    Flamand, N.4    Tremblay, Y.5
  • 37
    • 0030925164 scopus 로고    scopus 로고
    • Kinetic behavior in vitro and the dehydrogenase/reductase activity ratio of A431 cells in culture suggest intracellular regulation of 17b-hydroxysteroid dehydrogenase type 2 at the level of catalysis to function predominantly as a dehydrogenase
    • Blomquist C.H., Leung B.S., Beaudoin C., Poirier D., Tremblay Y. Kinetic behavior in vitro and the dehydrogenase/reductase activity ratio of A431 cells in culture suggest intracellular regulation of 17b-hydroxysteroid dehydrogenase type 2 at the level of catalysis to function predominantly as a dehydrogenase. J. Endocrinol. 1997, 153:453-464.
    • (1997) J. Endocrinol. , vol.153 , pp. 453-464
    • Blomquist, C.H.1    Leung, B.S.2    Beaudoin, C.3    Poirier, D.4    Tremblay, Y.5
  • 38
    • 0033621736 scopus 로고    scopus 로고
    • Differential expression of 17beta-hydroxysteroid dehydrogenases types 2 and 4 in human endometrial epithelial cell lines
    • Husen B., Psonka N., Jacob-Meisel M., Keil C., Rune G.M. Differential expression of 17beta-hydroxysteroid dehydrogenases types 2 and 4 in human endometrial epithelial cell lines. J. Mol. Endocrinol. 2000, 24:135-144.
    • (2000) J. Mol. Endocrinol. , vol.24 , pp. 135-144
    • Husen, B.1    Psonka, N.2    Jacob-Meisel, M.3    Keil, C.4    Rune, G.M.5
  • 39
    • 41549112390 scopus 로고    scopus 로고
    • Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids
    • L'Esperance S., Bachvarova M., Tetu B., Mes-Masson A.M., Bachvarov D. Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids. BMC Genomics 2008, 9:99.
    • (2008) BMC Genomics , vol.9 , pp. 99
    • L'Esperance, S.1    Bachvarova, M.2    Tetu, B.3    Mes-Masson, A.M.4    Bachvarov, D.5
  • 41
    • 0020609478 scopus 로고
    • Cytosol and nuclear estrogen and progestin receptors and 17 beta-hydroxysteroid dehydrogenase activity in non-diseased tissue and in benign and malignant tumors of the human ovary
    • Vierikko P., Kauppila A., Vihko R. Cytosol and nuclear estrogen and progestin receptors and 17 beta-hydroxysteroid dehydrogenase activity in non-diseased tissue and in benign and malignant tumors of the human ovary. Int. J. Cancer 1983, 32:413-422.
    • (1983) Int. J. Cancer , vol.32 , pp. 413-422
    • Vierikko, P.1    Kauppila, A.2    Vihko, R.3
  • 43
    • 0035529054 scopus 로고    scopus 로고
    • Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence
    • Gunnarsson C., Olsson B.M., Stal O. Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence. Cancer Res. 2001, 61:8448-8451.
    • (2001) Cancer Res. , vol.61 , pp. 8448-8451
    • Gunnarsson, C.1    Olsson, B.M.2    Stal, O.3
  • 46
    • 33751100414 scopus 로고    scopus 로고
    • Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors
    • Jansson A., Gunnarsson C., Stal O. Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors. Endocr. Relat. Cancer 2006, 13:875-884.
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 875-884
    • Jansson, A.1    Gunnarsson, C.2    Stal, O.3
  • 48
    • 33947628632 scopus 로고    scopus 로고
    • Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism
    • e391-397; discussion 391, e397-398
    • Cheng Y.H., Imir A., Fenkci V., Yilmaz M.B., Bulun S.E. Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism. Am. J. Obstet. Gynecol. 2007, 196:391. e391-397; discussion 391, e397-398.
    • (2007) Am. J. Obstet. Gynecol. , vol.196 , pp. 391
    • Cheng, Y.H.1    Imir, A.2    Fenkci, V.3    Yilmaz, M.B.4    Bulun, S.E.5
  • 49
    • 43249124391 scopus 로고    scopus 로고
    • Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    • Cheng Y.H., Yin P., Xue Q., Yilmaz B., Dawson M.I., Bulun S.E. Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J. Clin. Endocrinol. Metab. 2008, 93:1915-1923.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1915-1923
    • Cheng, Y.H.1    Yin, P.2    Xue, Q.3    Yilmaz, B.4    Dawson, M.I.5    Bulun, S.E.6
  • 50
    • 3543068881 scopus 로고    scopus 로고
    • Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells
    • Khan N., Sharma K.K., Andersson S., Auchus R.J. Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells. Arch. Biochem. Biophys. 2004, 429:50-59.
    • (2004) Arch. Biochem. Biophys. , vol.429 , pp. 50-59
    • Khan, N.1    Sharma, K.K.2    Andersson, S.3    Auchus, R.J.4
  • 51
    • 13844299310 scopus 로고    scopus 로고
    • Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer
    • Lee P., Rosen D.G., Zhu C., Silva E.G., Liu J. Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer. Gynecol. Oncol. 2005, 96:671-677.
    • (2005) Gynecol. Oncol. , vol.96 , pp. 671-677
    • Lee, P.1    Rosen, D.G.2    Zhu, C.3    Silva, E.G.4    Liu, J.5
  • 52
    • 0347480517 scopus 로고    scopus 로고
    • 17Beta-hydroxysteroid dehydrogenase type 2: independent prognostic significance and evidence of estrogen protection in female patients with colon cancer
    • Oduwole O.O., Makinen M.J., Isomaa V.V., Pulkka A., Jernvall P., Karttunen T.J., Vihko P.T. 17Beta-hydroxysteroid dehydrogenase type 2: independent prognostic significance and evidence of estrogen protection in female patients with colon cancer. J. Steroid Biochem. Mol. Biol. 2003, 87:133-140.
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.87 , pp. 133-140
    • Oduwole, O.O.1    Makinen, M.J.2    Isomaa, V.V.3    Pulkka, A.4    Jernvall, P.5    Karttunen, T.J.6    Vihko, P.T.7
  • 53
    • 19344377563 scopus 로고    scopus 로고
    • Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids
    • Blomquist C.H., Lima P.H., Hotchkiss J.R. Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids. Steroids 2005, 70:507-514.
    • (2005) Steroids , vol.70 , pp. 507-514
    • Blomquist, C.H.1    Lima, P.H.2    Hotchkiss, J.R.3
  • 54
    • 71749120228 scopus 로고    scopus 로고
    • Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone
    • Moller G., Deluca D., Gege C., Rosinus A., Kowalik D., Peters O., Droescher P., Elger W., Adamski J., Hillisch A. Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone. Bioorg. Med. Chem. Lett. 2009, 19:6740-6744.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6740-6744
    • Moller, G.1    Deluca, D.2    Gege, C.3    Rosinus, A.4    Kowalik, D.5    Peters, O.6    Droescher, P.7    Elger, W.8    Adamski, J.9    Hillisch, A.10


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