-
1
-
-
53449086382
-
Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases
-
Allen, J.A., Yadav, P.N., and Roth, B.L. 2008. Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases. Neuropharmacology 55: 961-968.
-
(2008)
Neuropharmacology
, vol.55
, pp. 961-968
-
-
Allen, J.A.1
Yadav, P.N.2
Roth, B.L.3
-
2
-
-
0031815337
-
Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
-
Berg, K.A., Maayani, S., Goldfarb, J., Scaramellini, C., Leff, P., and Clarke, W.P. 1998. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54: 94-104.
-
(1998)
Mol. Pharmacol
, vol.54
, pp. 94-104
-
-
Berg, K.A.1
Maayani, S.2
Goldfarb, J.3
Scaramellini, C.4
Leff, P.5
Clarke, W.P.6
-
3
-
-
0032587722
-
5-Hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and Jun d as common components in cerebellar neurons
-
Chalecka-Franaszek, E., Chen, H., and Chuang, D.M. 1999. 5-Hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and Jun d as common components in cerebellar neurons. Neuroscience 88: 885-898.
-
(1999)
Neuroscience
, vol.88
, pp. 885-898
-
-
Chalecka-Franaszek, E.1
Chen, H.2
Chuang, D.M.3
-
4
-
-
58149193205
-
Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders
-
Conn, P.J., Christopoulos, A., and Lindsley, C.W. 2009. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat. Rev. Drug Discov. 8: 41-54.
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 41-54
-
-
Conn, P.J.1
Christopoulos, A.2
Lindsley, C.W.3
-
5
-
-
0032971464
-
Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: The third intracellular loop is alpha-helical and binds purified arrestins
-
Gelber, E.I., Kroeze, W.K., Willins, D.L., Gray, J.A., Sinar, C.A., Hyde, E.G., Gurevich, V., Benovic, J., and Roth, B.L. 1999. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. J. Neurochem. 72: 2206-2214.
-
(1999)
J. Neurochem
, vol.72
, pp. 2206-2214
-
-
Gelber, E.I.1
Kroeze, W.K.2
Willins, D.L.3
Gray, J.A.4
Sinar, C.A.5
Hyde, E.G.6
Gurevich, V.7
Benovic, J.8
Roth, B.L.9
-
6
-
-
0025232511
-
Serotonin receptors: Clinical implications
-
Glennon, R. 1990. Serotonin receptors: clinical implications. Neurosci. Biobehav. Rev. 14: 35-47.
-
(1990)
Neurosci. Biobehav. Rev
, vol.14
, pp. 35-47
-
-
Glennon, R.1
-
7
-
-
33846549510
-
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior
-
González-Maeso, J., Weisstaub, N.V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., Sealfon, S.C., and Gingrich, J.A. 2007. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron 53: 439-452.
-
(2007)
Neuron
, vol.53
, pp. 439-452
-
-
González-Maeso, J.1
Weisstaub, N.V.2
Zhou, M.3
Chan, P.4
Ivic, L.5
Ang, R.6
Lira, A.7
Bradley-Moore, M.8
Ge, Y.9
Zhou, Q.10
Sealfon, S.C.11
Gingrich, J.A.12
-
8
-
-
0141753077
-
Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex
-
González-Maeso, J., Yuen, T., Ebersole, B.J., Wurmbach, E., Lira, A., Zhou, M., Weisstaub, N., Hen, R., Gingrich, J.A., and Sealfon, S.C. 2003. Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J. Neurosci. 23: 8836-8843.
-
(2003)
J. Neurosci
, vol.23
, pp. 8836-8843
-
-
González-Maeso, J.1
Yuen, T.2
Ebersole, B.J.3
Wurmbach, E.4
Lira, A.5
Zhou, M.6
Weisstaub, N.7
Hen, R.8
Gingrich, J.A.9
Sealfon, S.C.10
-
9
-
-
0035891883
-
Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists
-
Gray, J.A. and Roth, B.L. 2001. Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res. Bull. 56: 441-451.
-
(2001)
Brain Res. Bull
, vol.56
, pp. 441-451
-
-
Gray, J.A.1
Roth, B.L.2
-
10
-
-
0034753012
-
Cell-type specific effects of endocytosis inhibitors on 5-hy- droxytryptamine (2A) receptor desensitization and resensi-tization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells
-
Gray, J.A., Sheffler, D.J., Bhatnagar, A., Woods, J.A., Hufeisen, S.J., Benovic, J.L., and Roth, B.L. 2001. Cell-type specific effects of endocytosis inhibitors on 5-hy- droxytryptamine (2A) receptor desensitization and resensi-tization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol. Pharmacol. 60: 1020-1030.
-
(2001)
Mol. Pharmacol
, vol.60
, pp. 1020-1030
-
-
Gray, J.A.1
Sheffler, D.J.2
Bhatnagar, A.3
Woods, J.A.4
Hufeisen, S.J.5
Benovic, J.L.6
Roth, B.L.7
-
11
-
-
0034644509
-
Signaling networks: The origins of cellular multitasking
-
Jordan, J.D., Landau, E.M., and Iyengar, R. 2000. Signaling networks: the origins of cellular multitasking. Cell 103:193-200.
-
(2000)
Cell
, vol.103
, pp. 193-200
-
-
Jordan, J.D.1
Landau, E.M.2
Iyengar, R.3
-
12
-
-
0029054965
-
Agonist-receptor efficacy. II. Agonist trafficking of receptor signals
-
Kenakin, T. 1995. Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol. Sci. 16: 232-238.
-
(1995)
Trends Pharmacol. Sci
, vol.16
, pp. 232-238
-
-
Kenakin, T.1
-
13
-
-
0035430282
-
Transcriptional regulation by the phosphorylation-dependent factor CREB
-
Mayr, B. and Montminy, M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2: 599-609.
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 599-609
-
-
Mayr, B.1
Montminy, M.2
-
14
-
-
0037944275
-
Constitutively activated G protein-coupled receptors: A novel approach to CNS drug discovery
-
Menzaghi, F., Behan, D.P., and Chalmers, D.T. 2002. Constitutively activated G protein-coupled receptors: a novel approach to CNS drug discovery. Curr. Drug Targets CNS Neurol. Disord. 1: 105-121.
-
(2002)
Curr. Drug Targets CNS Neurol. Disord
, vol.1
, pp. 105-121
-
-
Menzaghi, F.1
Behan, D.P.2
Chalmers, D.T.3
-
15
-
-
0029851272
-
Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: Comparative stimulation by hallucinogenic drugs
-
Newton, R.A., Phipps, S.L., Flanigan, T.P., Newberry, N.R., Carey, J.E., Kumar, C., Mcdonald, B., Chen, C., and Elliott, J.M. 1996. Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs. J. Neurochem. 67: 2521-2531.
-
(1996)
J. Neurochem
, vol.67
, pp. 2521-2531
-
-
Newton, R.A.1
Phipps, S.L.2
Flanigan, T.P.3
Newberry, N.R.4
Carey, J.E.5
Kumar, C.6
McDonald, B.7
Chen, C.8
Elliott, J.M.9
-
16
-
-
39149131032
-
Emotional behavior and expression patterns of tyrosine hydroxylase and tryptophan hydroxylase in senescence-accelerated mouse (SAM) P6 mice
-
Niimi, K., Takahashi, E., and Itakura, C. 2008. Emotional behavior and expression patterns of tyrosine hydroxylase and tryptophan hydroxylase in senescence-accelerated mouse (SAM) P6 mice. Behav. Brain Res. 188: 329-336.
-
(2008)
Behav. Brain Res
, vol.188
, pp. 329-336
-
-
Niimi, K.1
Takahashi, E.2
Itakura, C.3
-
17
-
-
0028176806
-
2 receptor family mRNAs: Comparison between 5-HT2A and 5-HT2C receptors
-
2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Mol. Brain Res. 23: 163-178.
-
(1994)
Mol. Brain Res
, vol.23
, pp. 163-178
-
-
Pompeiano, M.1
Palacios, J.M.2
Mengod, G.3
-
18
-
-
38949210817
-
Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo
-
Schmid, C.L., Raehal, K.M., and Bohn, L.M. 2008. Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proc. Natl. Acad. Sci. U.S.A. 105: 1079-1084.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 1079-1084
-
-
Schmid, C.L.1
Raehal, K.M.2
Bohn, L.M.3
-
19
-
-
0033014541
-
Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: Down-regulation of the 5-HT2A, but not 5-HT2C, receptor
-
Smith, R.L., Barrett, R.J., and Sanders-Bush, E. 1999.Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor. Psychopharmacology 144: 248-254.
-
(1999)
Psychopharmacology
, vol.144
, pp. 248-254
-
-
Smith, R.L.1
Barrett, R.J.2
Sanders-Bush, E.3
-
20
-
-
0032847560
-
Senescence-accelerated mouse (SAM): A biogerontological resource in aging research. Neurobiol
-
Takeda, T. 1999. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiol. Aging 20: 105-110.
-
(1999)
Aging
, vol.20
, pp. 105-110
-
-
Takeda, T.1
-
21
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
Urban, J.D., Clarke, W.P., von Zastrow, M., Nichols, D.E., Kobilka, B., Weinstein, H., Javitch, J.A., Roth, B.L., Christopoulos, A., Sexton, P.M., Miller, K.J., Spedding, M., and Mailman, R.B. 2007. Functional selectivity and classical concepts of quantitative pharmacology. J. Pharmacol. Exp.Ther, 320; 1-13.
-
(2007)
J. Pharmacol. Exp.Ther
, vol.320
, pp. 1-13
-
-
Urban, J.D.1
Clarke, W.P.2
von Zastrow, M.3
Nichols, D.E.4
Kobilka, B.5
Weinstein, H.6
Javitch, J.A.7
Roth, B.L.8
Christopoulos, A.9
Sexton, P.M.10
Miller, K.J.11
Spedding, M.12
Mailman, R.B.13
-
22
-
-
34447649922
-
Beta-arrestin-biased ligands at seven-transmembrane receptors
-
Violin, J.D. and Lefkowitz, R.J. 2007. Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol. Sci. 28: 416-422.
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 416-422
-
-
Violin, J.D.1
Lefkowitz, R.J.2
-
23
-
-
0030752477
-
Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats
-
Willins, D.L. and Meltzer, H.Y. 1997. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. J. Pharmacol. Exp. Ther. 282: 699-706.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.282
, pp. 699-706
-
-
Willins, D.L.1
Meltzer, H.Y.2
-
24
-
-
0029789643
-
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
-
Xing, J., Ginty, D.D., and Greenberg, M.E. 1996. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273: 959-963.
-
(1996)
Science
, vol.273
, pp. 959-963
-
-
Xing, J.1
Ginty, D.D.2
Greenberg, M.E.3
|