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Volumn 36, Issue 8, 2010, Pages 950-961

Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites

Author keywords

Comet assay; DNA damage; Myeloperoxidase; PCB3 hydroquinone; PCB3 para quinone; Reactive oxygen species

Indexed keywords

BIOMOLECULES; CALCIUM ION SENSORS; CELL CULTURE; CHROMOSOMES; CYTOLOGY; DNA; ENZYMES; METABOLITES; OXYGEN; PHENOLS; PROTEINS;

EID: 77957242414     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2009.12.004     Document Type: Article
Times cited : (15)

References (77)
  • 1
    • 0029863866 scopus 로고    scopus 로고
    • Metabolic activation of PCBs to quinones: reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase
    • Amaro A.R., Oakley G.G., Bauer U., Robertson L.W., Spielmann H.P. Metabolic activation of PCBs to quinones: reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase. Chem Res Toxicol 1996, 9(3):623-629.
    • (1996) Chem Res Toxicol , vol.9 , Issue.3 , pp. 623-629
    • Amaro, A.R.1    Oakley, G.G.2    Bauer, U.3    Robertson, L.W.4    Spielmann, H.P.5
  • 2
    • 33644994856 scopus 로고    scopus 로고
    • Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases
    • Arlt V.M., Henderson C.J., Wolf C.R., Schmeiser H.H., Phillips D.H., Stiborova M. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases. Cancer Lett 2006, 234(2):220-231.
    • (2006) Cancer Lett , vol.234 , Issue.2 , pp. 220-231
    • Arlt, V.M.1    Henderson, C.J.2    Wolf, C.R.3    Schmeiser, H.H.4    Phillips, D.H.5    Stiborova, M.6
  • 4
    • 0018178223 scopus 로고
    • Oxygen-dependent microbial killing by phagocytes (second of two parts)
    • Babior B.M. Oxygen-dependent microbial killing by phagocytes (second of two parts). N Engl J Med 1978, 298(13):721-725.
    • (1978) N Engl J Med , vol.298 , Issue.13 , pp. 721-725
    • Babior, B.M.1
  • 5
    • 0025043947 scopus 로고
    • Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples
    • Baker M.A., Cerniglia G.J., Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 1990, 190(2):360-365.
    • (1990) Anal Biochem , vol.190 , Issue.2 , pp. 360-365
    • Baker, M.A.1    Cerniglia, G.J.2    Zaman, A.3
  • 6
    • 33747466075 scopus 로고    scopus 로고
    • Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate
    • Bender R.P., Lehmler H.J., Robertson L.W., Ludewig G., Osheroff N. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry 2006, 45(33):10140-10152.
    • (2006) Biochemistry , vol.45 , Issue.33 , pp. 10140-10152
    • Bender, R.P.1    Lehmler, H.J.2    Robertson, L.W.3    Ludewig, G.4    Osheroff, N.5
  • 7
    • 0028292741 scopus 로고
    • Selective retention of hydroxylated PCB metabolites in blood
    • Bergman A., Klasson-Wehler E., Kuroki H. Selective retention of hydroxylated PCB metabolites in blood. Environ Health Perspect 1994, 102(5):464-469.
    • (1994) Environ Health Perspect , vol.102 , Issue.5 , pp. 464-469
    • Bergman, A.1    Klasson-Wehler, E.2    Kuroki, H.3
  • 8
    • 0025012904 scopus 로고
    • Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase
    • Bozeman P.M., Learn D.B., Thomas E.L. Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. J Immunol Methods 1990, 126(1):125-133.
    • (1990) J Immunol Methods , vol.126 , Issue.1 , pp. 125-133
    • Bozeman, P.M.1    Learn, D.B.2    Thomas, E.L.3
  • 11
    • 0031950521 scopus 로고    scopus 로고
    • Assessing the cancer risk from environmental PCBs
    • Cogliano V.J. Assessing the cancer risk from environmental PCBs. Environ Health Perspect 1998, 106(6):317-323.
    • (1998) Environ Health Perspect , vol.106 , Issue.6 , pp. 317-323
    • Cogliano, V.J.1
  • 13
    • 0025915662 scopus 로고
    • Glutathione depletion: its effects on other antioxidant systems and hepatocellular damage
    • Comporti M., Maellaro E., Del Bello B., Casini A.F. Glutathione depletion: its effects on other antioxidant systems and hepatocellular damage. Xenobiotica 1991, 21(8):1067-1076.
    • (1991) Xenobiotica , vol.21 , Issue.8 , pp. 1067-1076
    • Comporti, M.1    Maellaro, E.2    Del Bello, B.3    Casini, A.F.4
  • 15
    • 0036190034 scopus 로고    scopus 로고
    • Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers
    • Dean C.E., Benjamin S.A., Chubb L.S., Tessari J.D., Keefe T.J. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicol Sci 2002, 66(1):54-61.
    • (2002) Toxicol Sci , vol.66 , Issue.1 , pp. 54-61
    • Dean, C.E.1    Benjamin, S.A.2    Chubb, L.S.3    Tessari, J.D.4    Keefe, T.J.5
  • 20
    • 33746211294 scopus 로고    scopus 로고
    • Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells
    • Fan Y., Schreiber E.M., Giorgianni A., Yalowich J.C., Day B.W. Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells. Chem Res Toxicol 2006, 19(7):937-943.
    • (2006) Chem Res Toxicol , vol.19 , Issue.7 , pp. 937-943
    • Fan, Y.1    Schreiber, E.M.2    Giorgianni, A.3    Yalowich, J.C.4    Day, B.W.5
  • 21
    • 0025066530 scopus 로고
    • The use of monochlorobimane to determine hepatic GSH levels and synthesis
    • Fernandez-Checa J.C., Kaplowitz N. The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem 1990, 190(2):212-219.
    • (1990) Anal Biochem , vol.190 , Issue.2 , pp. 212-219
    • Fernandez-Checa, J.C.1    Kaplowitz, N.2
  • 22
    • 0025045198 scopus 로고
    • The role of 8-hydroxyguanine in carcinogenesis
    • Floyd R.A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 1990, 11(9):1447-1450.
    • (1990) Carcinogenesis , vol.11 , Issue.9 , pp. 1447-1450
    • Floyd, R.A.1
  • 23
    • 0033863276 scopus 로고    scopus 로고
    • Analysis of rat liver foci growth with a quantitative two-cell model after treatment with 2, 4, 5, 3', 4'-Pentachlorobiphenyl
    • Haag-Gronlund M., Conolly R., Scheu G., Warngard L., Fransson-Steen R. Analysis of rat liver foci growth with a quantitative two-cell model after treatment with 2, 4, 5, 3', 4'-Pentachlorobiphenyl. Toxicol Sci 2000, 57(1):32-42.
    • (2000) Toxicol Sci , vol.57 , Issue.1 , pp. 32-42
    • Haag-Gronlund, M.1    Conolly, R.2    Scheu, G.3    Warngard, L.4    Fransson-Steen, R.5
  • 24
    • 0026720020 scopus 로고
    • Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique
    • Hanna P.M., Mason R.P. Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique. Arch Biochem Biophys 1992, 295(1):205-213.
    • (1992) Arch Biochem Biophys , vol.295 , Issue.1 , pp. 205-213
    • Hanna, P.M.1    Mason, R.P.2
  • 25
    • 30544452175 scopus 로고    scopus 로고
    • Biosynthesis, processing, and sorting of human myeloperoxidase
    • Hansson M., Olsson I., Nauseef W.M. Biosynthesis, processing, and sorting of human myeloperoxidase. Arch Biochem Biophys 2006, 445(2):214-224.
    • (2006) Arch Biochem Biophys , vol.445 , Issue.2 , pp. 214-224
    • Hansson, M.1    Olsson, I.2    Nauseef, W.M.3
  • 27
    • 4344703244 scopus 로고    scopus 로고
    • Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis
    • Ibuki Y., Goto R. Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis. Biochim Biophys Acta (BBA) - Mol Basis Dis 2004, 1690(1):11-21.
    • (2004) Biochim Biophys Acta (BBA) - Mol Basis Dis , vol.1690 , Issue.1 , pp. 11-21
    • Ibuki, Y.1    Goto, R.2
  • 28
    • 23444447992 scopus 로고    scopus 로고
    • Time- and tissue-dependent polychlorinated biphenyl residues in hairless mice after exposure to polychlorinated biphenyl-contaminated soil
    • Imsilp K., Wiedenmann L., Bordson G.O., Morrow C.K., Cope R., Hansen L.G. Time- and tissue-dependent polychlorinated biphenyl residues in hairless mice after exposure to polychlorinated biphenyl-contaminated soil. Arch Environ Con Tox 2005, 49(1):105-118.
    • (2005) Arch Environ Con Tox , vol.49 , Issue.1 , pp. 105-118
    • Imsilp, K.1    Wiedenmann, L.2    Bordson, G.O.3    Morrow, C.K.4    Cope, R.5    Hansen, L.G.6
  • 29
    • 0027763462 scopus 로고
    • Metabolism of 2-aminofluorene by human polymorphonuclear leukocytes: more evidence for the association between inflammation and cancer
    • Isola V.J., Hartman T.C., Trumble S.J., Ruzek M.C., Gentile J.M. Metabolism of 2-aminofluorene by human polymorphonuclear leukocytes: more evidence for the association between inflammation and cancer. Environ Health Perspect 1993, 101(Suppl 3):27-31.
    • (1993) Environ Health Perspect , vol.101 , Issue.SUPPL 3 , pp. 27-31
    • Isola, V.J.1    Hartman, T.C.2    Trumble, S.J.3    Ruzek, M.C.4    Gentile, J.M.5
  • 30
    • 38349159807 scopus 로고    scopus 로고
    • 2-(4'-chlorophenyl)-1, 4-benzoquinone increases the frequency of micronuclei and shortens telomeres
    • Jacobus J.A., Flor S., Klingelhutz A., Robertson L.W., Ludewig G. 2-(4'-chlorophenyl)-1, 4-benzoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Phar 2008, 25(2):267-272.
    • (2008) Environ Toxicol Phar , vol.25 , Issue.2 , pp. 267-272
    • Jacobus, J.A.1    Flor, S.2    Klingelhutz, A.3    Robertson, L.W.4    Ludewig, G.5
  • 31
    • 0034696829 scopus 로고    scopus 로고
    • Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2, 2, 5, 7, 8-Pentamethyl-6-hydroxychromane, do not induce oxidative stress in live HL-60 cells
    • Kagan V.E., Kuzmenko A.I., Shvedova A.A., Kisin E.R., Tyurina Y.Y., Yalowich J.C. Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2, 2, 5, 7, 8-Pentamethyl-6-hydroxychromane, do not induce oxidative stress in live HL-60 cells. Biochem Biophys Res Commun 2000, 270(3):1086-1092.
    • (2000) Biochem Biophys Res Commun , vol.270 , Issue.3 , pp. 1086-1092
    • Kagan, V.E.1    Kuzmenko, A.I.2    Shvedova, A.A.3    Kisin, E.R.4    Tyurina, Y.Y.5    Yalowich, J.C.6
  • 32
    • 0025942606 scopus 로고
    • The role of hepatic metabolites of benzene in bone marrow peroxidase-mediated myelo- and genotoxicity
    • Kalf G., Shurina R., Renz J., Schlosser M. The role of hepatic metabolites of benzene in bone marrow peroxidase-mediated myelo- and genotoxicity. Adv Exp Med Biol 1991, 283:443-455.
    • (1991) Adv Exp Med Biol , vol.283 , pp. 443-455
    • Kalf, G.1    Shurina, R.2    Renz, J.3    Schlosser, M.4
  • 33
    • 0014292067 scopus 로고
    • Myeloperoxidase-halide-hydrogen peroxide antibacterial system
    • Klebanoff S.J. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J Bacteriol 1968, 95(6):2131-2138.
    • (1968) J Bacteriol , vol.95 , Issue.6 , pp. 2131-2138
    • Klebanoff, S.J.1
  • 34
    • 0033841245 scopus 로고    scopus 로고
    • N-Acetylbenzidine-DNA adduct formation by phorbol 12-myristate-stimulated human polymorphonuclear neutrophils
    • Lakshmi V.M., Hsu F.F., Davis B.B., Zenser T.V. N-Acetylbenzidine-DNA adduct formation by phorbol 12-myristate-stimulated human polymorphonuclear neutrophils. Chem Res Toxicol 2000, 13(8):785-792.
    • (2000) Chem Res Toxicol , vol.13 , Issue.8 , pp. 785-792
    • Lakshmi, V.M.1    Hsu, F.F.2    Davis, B.B.3    Zenser, T.V.4
  • 35
    • 33847324861 scopus 로고    scopus 로고
    • 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats
    • Lehmann L., Esch H.L., Kirby P.A., Robertson L.W., Ludewig G. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 2007, 28(2):471-478.
    • (2007) Carcinogenesis , vol.28 , Issue.2 , pp. 471-478
    • Lehmann, L.1    Esch, H.L.2    Kirby, P.A.3    Robertson, L.W.4    Ludewig, G.5
  • 36
    • 0033845964 scopus 로고    scopus 로고
    • Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2, 2', 5, 5'-tetrachlorobiphenyl
    • Lin P.H., Sangaiah R., Ranasinghe A., Upton P.B., La D.K., Gold A., Swenberg J.A. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2, 2', 5, 5'-tetrachlorobiphenyl. Chem Res Toxicol 2000, 13(8):710-718.
    • (2000) Chem Res Toxicol , vol.13 , Issue.8 , pp. 710-718
    • Lin, P.H.1    Sangaiah, R.2    Ranasinghe, A.3    Upton, P.B.4    La, D.K.5    Gold, A.6    Swenberg, J.A.7
  • 37
    • 38549087443 scopus 로고    scopus 로고
    • Metabolic activation of PCBs to carcinogens in vivo - a review
    • Ludewig G., Lehmann L., Esch H., Robertson L.W. Metabolic activation of PCBs to carcinogens in vivo - a review. Environ Toxicol Phar 2008, 25(2):241-246.
    • (2008) Environ Toxicol Phar , vol.25 , Issue.2 , pp. 241-246
    • Ludewig, G.1    Lehmann, L.2    Esch, H.3    Robertson, L.W.4
  • 38
    • 0033929006 scopus 로고    scopus 로고
    • Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion
    • Ludewig G., Srinivasan A., Robertson L.W. Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Cent Eur J Public Health 2000, 8:15-17. Suppl.
    • (2000) Cent Eur J Public Health , vol.8 , Issue.SUPPL. , pp. 15-17
    • Ludewig, G.1    Srinivasan, A.2    Robertson, L.W.3
  • 39
    • 41949090942 scopus 로고    scopus 로고
    • Hydroquinone-induced genotoxicity and oxidative DNA damage in HepG2 cells
    • Luo L., Jiang L., Geng C., Cao J., Zhong L. Hydroquinone-induced genotoxicity and oxidative DNA damage in HepG2 cells. Chem Biol Interact 2008, 173(1):1-8.
    • (2008) Chem Biol Interact , vol.173 , Issue.1 , pp. 1-8
    • Luo, L.1    Jiang, L.2    Geng, C.3    Cao, J.4    Zhong, L.5
  • 40
    • 38549161119 scopus 로고    scopus 로고
    • Mutagenicity of 3-methylcholanthrene, Pcb3, and 4-Oh-Pcb3 in the lung of transgenic bigblue rats
    • Maddox C., Wang B., Kirby P.A., Wang K., Ludewig G. Mutagenicity of 3-methylcholanthrene, Pcb3, and 4-Oh-Pcb3 in the lung of transgenic bigblue rats. Environ Toxicol Phar 2008, 25(2):260-266.
    • (2008) Environ Toxicol Phar , vol.25 , Issue.2 , pp. 260-266
    • Maddox, C.1    Wang, B.2    Kirby, P.A.3    Wang, K.4    Ludewig, G.5
  • 43
    • 0030051958 scopus 로고    scopus 로고
    • Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl
    • McLean M.R., Bauer U., Robertson L.W., Amaro A.R. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem Res Toxicol 1996, 9(1):158-164.
    • (1996) Chem Res Toxicol , vol.9 , Issue.1 , pp. 158-164
    • McLean, M.R.1    Bauer, U.2    Robertson, L.W.3    Amaro, A.R.4
  • 44
    • 0030049843 scopus 로고    scopus 로고
    • Detection of PCB adducts by the 32P-postlabeling technique
    • McLean M.R., Robertson L.W., Gupta R.C. Detection of PCB adducts by the 32P-postlabeling technique. Chem Res Toxicol 1996, 9(1):165-171.
    • (1996) Chem Res Toxicol , vol.9 , Issue.1 , pp. 165-171
    • McLean, M.R.1    Robertson, L.W.2    Gupta, R.C.3
  • 45
    • 0034656402 scopus 로고    scopus 로고
    • Redox cycling of 2-(x'-mono, -di, -trichlorophenyl)- 1, 4-benzoquinones, oxidation products of polychlorinated biphenyls
    • McLean M.R., Twaroski T.P., Robertson L.W. Redox cycling of 2-(x'-mono, -di, -trichlorophenyl)- 1, 4-benzoquinones, oxidation products of polychlorinated biphenyls. Arch Biochem Biophys 2000, 376(2):449-455.
    • (2000) Arch Biochem Biophys , vol.376 , Issue.2 , pp. 449-455
    • McLean, M.R.1    Twaroski, T.P.2    Robertson, L.W.3
  • 46
    • 34848852035 scopus 로고    scopus 로고
    • Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells
    • Nakazato T., Sagawa M., Yamato K., Xian M., Yamamoto T., Suematsu M., Ikeda Y., Kizaki M. Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells. Clin Cancer Res 2007, 13(18):5436-5445.
    • (2007) Clin Cancer Res , vol.13 , Issue.18 , pp. 5436-5445
    • Nakazato, T.1    Sagawa, M.2    Yamato, K.3    Xian, M.4    Yamamoto, T.5    Suematsu, M.6    Ikeda, Y.7    Kizaki, M.8
  • 47
    • 0020533077 scopus 로고
    • Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency
    • Nauseef W.M., Root R.K., Malech H.L. Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency. J Clin Invest 1983, 71(5):1297-1307.
    • (1983) J Clin Invest , vol.71 , Issue.5 , pp. 1297-1307
    • Nauseef, W.M.1    Root, R.K.2    Malech, H.L.3
  • 48
    • 2442440907 scopus 로고    scopus 로고
    • Role of reactive oxygen species in skin carcinogenesis
    • Nishigori C., Hattori Y., Toyokuni S. Role of reactive oxygen species in skin carcinogenesis. Antioxid Redox Sign 2004, 6(3):561-570.
    • (2004) Antioxid Redox Sign , vol.6 , Issue.3 , pp. 561-570
    • Nishigori, C.1    Hattori, Y.2    Toyokuni, S.3
  • 49
    • 0029803656 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer
    • Oakley G.G., Devanaboyina U., Robertson L.W., Gupta R.C. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer. Chem Res Toxicol 1996, 9(8):1285-1292.
    • (1996) Chem Res Toxicol , vol.9 , Issue.8 , pp. 1285-1292
    • Oakley, G.G.1    Devanaboyina, U.2    Robertson, L.W.3    Gupta, R.C.4
  • 50
    • 0029972543 scopus 로고    scopus 로고
    • Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling
    • Oakley G.G., Robertson L.W., Gupta R.C. Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling. Carcinogenesis 1996, 17(1):109-114.
    • (1996) Carcinogenesis , vol.17 , Issue.1 , pp. 109-114
    • Oakley, G.G.1    Robertson, L.W.2    Gupta, R.C.3
  • 51
    • 0024576709 scopus 로고
    • Cell calcium, vitamin E, and the thiol redox system in cytotoxicity
    • Pascoe G.A., Reed D.J. Cell calcium, vitamin E, and the thiol redox system in cytotoxicity. Free Radic Biol Med 1989, 6(2):209-224.
    • (1989) Free Radic Biol Med , vol.6 , Issue.2 , pp. 209-224
    • Pascoe, G.A.1    Reed, D.J.2
  • 52
    • 0020531080 scopus 로고
    • Differences in myeloperoxidase activity from neutrophilic polymorphonuclear leukocytes of differing density: relationship to selective exocytosis of distinct forms of the enzyme
    • Pember S.O., Kinkade J.M. Differences in myeloperoxidase activity from neutrophilic polymorphonuclear leukocytes of differing density: relationship to selective exocytosis of distinct forms of the enzyme. Blood 1983, 61(6):1116-1124.
    • (1983) Blood , vol.61 , Issue.6 , pp. 1116-1124
    • Pember, S.O.1    Kinkade, J.M.2
  • 56
    • 0024492933 scopus 로고
    • Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity
    • Safe S. Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity. Mutat Res 1989, 220(1):31-47.
    • (1989) Mutat Res , vol.220 , Issue.1 , pp. 31-47
    • Safe, S.1
  • 57
    • 0031606297 scopus 로고    scopus 로고
    • Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds
    • Safe S.H. Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds. J Anim Sci 1998, 76(1):134-141.
    • (1998) J Anim Sci , vol.76 , Issue.1 , pp. 134-141
    • Safe, S.H.1
  • 58
    • 0031013985 scopus 로고    scopus 로고
    • Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: attenuation by L-ascorbic acid
    • Sandoval M., Zhang X.-J., Liu X., Mannick E.E., Clark D.A., Miller M.J.S. Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: attenuation by L-ascorbic acid. Free Radic Biol Med 1997, 22(3):489-495.
    • (1997) Free Radic Biol Med , vol.22 , Issue.3 , pp. 489-495
    • Sandoval, M.1    Zhang, X.-J.2    Liu, X.3    Mannick, E.E.4    Clark, D.A.5    Miller, M.J.S.6
  • 59
    • 0025072322 scopus 로고
    • Capability of human blood cells to form the DNA adduct, C8-(N2-aminofluorenyl)-deoxyguanosine-3'-5'-diphosphate from 2-aminofluorene
    • Shen J.H., Wegenke M., Wolff T. Capability of human blood cells to form the DNA adduct, C8-(N2-aminofluorenyl)-deoxyguanosine-3'-5'-diphosphate from 2-aminofluorene. Carcinogenesis 1990, 11(8):1441-1444.
    • (1990) Carcinogenesis , vol.11 , Issue.8 , pp. 1441-1444
    • Shen, J.H.1    Wegenke, M.2    Wolff, T.3
  • 60
    • 0025068390 scopus 로고
    • Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs
    • Silberhorn E.M., Glauert H.P., Robertson L.W. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit Rev Toxicol 1990, 20(6):440-496.
    • (1990) Crit Rev Toxicol , vol.20 , Issue.6 , pp. 440-496
    • Silberhorn, E.M.1    Glauert, H.P.2    Robertson, L.W.3
  • 61
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988, 175(1):184-191.
    • (1988) Exp Cell Res , vol.175 , Issue.1 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 62
    • 0033675741 scopus 로고    scopus 로고
    • Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men
    • Sjodin A., Hagmar L., Klasson-Wehler E., Bjork J., Bergman A. Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environ Health Perspect 2000, 108(11):1035-1041.
    • (2000) Environ Health Perspect , vol.108 , Issue.11 , pp. 1035-1041
    • Sjodin, A.1    Hagmar, L.2    Klasson-Wehler, E.3    Bjork, J.4    Bergman, A.5
  • 63
    • 0034234990 scopus 로고    scopus 로고
    • Cellular glutathione status modulates polychlorinated biphenyl-induced stress response and apoptosis in vascular endothelial cells
    • Slim R., Toborek M., Robertson L.W., Lehmler H.J., Hennig B. Cellular glutathione status modulates polychlorinated biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 2000, 166(1):36-42.
    • (2000) Toxicol Appl Pharmacol , vol.166 , Issue.1 , pp. 36-42
    • Slim, R.1    Toborek, M.2    Robertson, L.W.3    Lehmler, H.J.4    Hennig, B.5
  • 64
    • 0028879241 scopus 로고
    • Effects of glutathione on Fenton reagent-dependent radical production and DNA oxidation
    • Spear N., Aust S.D. Effects of glutathione on Fenton reagent-dependent radical production and DNA oxidation. Arch Biochem Biophys 1995, 324(1):111-116.
    • (1995) Arch Biochem Biophys , vol.324 , Issue.1 , pp. 111-116
    • Spear, N.1    Aust, S.D.2
  • 66
    • 0035098162 scopus 로고    scopus 로고
    • Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites
    • Srinivasan A., Lehmler H.-J., Robertson L.W., Ludewig G. Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Toxicol Sci 2001, 60(1):92-102.
    • (2001) Toxicol Sci , vol.60 , Issue.1 , pp. 92-102
    • Srinivasan, A.1    Lehmler, H.-J.2    Robertson, L.W.3    Ludewig, G.4
  • 67
    • 0036223696 scopus 로고    scopus 로고
    • Sulfhydryl binding and topoisomerase inhibition by PCB metabolites
    • Srinivasan A., Robertson L.W., Ludewig G. Sulfhydryl binding and topoisomerase inhibition by PCB metabolites. Chem Res Toxicol 2002, 15(4):497-505.
    • (2002) Chem Res Toxicol , vol.15 , Issue.4 , pp. 497-505
    • Srinivasan, A.1    Robertson, L.W.2    Ludewig, G.3
  • 68
    • 0026046826 scopus 로고
    • Potential role of free radicals in benzene-induced myelotoxicity and leukemia
    • Subrahmanyam V.V., Ross D., Eastmond D.A., Smith M.T. Potential role of free radicals in benzene-induced myelotoxicity and leukemia. Free Radic Biol Med 1991, 11(5):495-515.
    • (1991) Free Radic Biol Med , vol.11 , Issue.5 , pp. 495-515
    • Subrahmanyam, V.V.1    Ross, D.2    Eastmond, D.A.3    Smith, M.T.4
  • 69
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues
    • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969, 27(3):502-522.
    • (1969) Anal Biochem , vol.27 , Issue.3 , pp. 502-522
    • Tietze, F.1
  • 70
    • 6944248952 scopus 로고    scopus 로고
    • Determining sources of atmospheric polychlorinated biphenyls based on their fracturing concentrations and congener compositions
    • Uraki Y., Suzuki S., Yasuhara A., Shibamoto T. Determining sources of atmospheric polychlorinated biphenyls based on their fracturing concentrations and congener compositions. J Environ Sci Health A Tox Hazard Subst Environ Eng 2004, 39(11-12):2755-2772.
    • (2004) J Environ Sci Health A Tox Hazard Subst Environ Eng , vol.39 , Issue.11-12 , pp. 2755-2772
    • Uraki, Y.1    Suzuki, S.2    Yasuhara, A.3    Shibamoto, T.4
  • 71
    • 0026441296 scopus 로고
    • Membrane peroxidative damage enhancement by the ether lipid class of antineoplastic agents
    • Wagner B.A., Buettner G.R., Burns C.P. Membrane peroxidative damage enhancement by the ether lipid class of antineoplastic agents. Cancer Res 1992, 52(21):6045-6051.
    • (1992) Cancer Res , vol.52 , Issue.21 , pp. 6045-6051
    • Wagner, B.A.1    Buettner, G.R.2    Burns, C.P.3
  • 73
    • 0024321035 scopus 로고
    • 3, 3', 4, 4'-Tetrachlorobiphenyl. Excretion and tissue retention of hydroxylated metabolites in the mouse
    • Wehler E.K., Bergman A., Brandt I., Darnerud P.O., Wachtmeister C.A. 3, 3', 4, 4'-Tetrachlorobiphenyl. Excretion and tissue retention of hydroxylated metabolites in the mouse. Drug Metab Dispos 1989, 17(4):441-448.
    • (1989) Drug Metab Dispos , vol.17 , Issue.4 , pp. 441-448
    • Wehler, E.K.1    Bergman, A.2    Brandt, I.3    Darnerud, P.O.4    Wachtmeister, C.A.5
  • 74
    • 33751224985 scopus 로고    scopus 로고
    • WHO, World Health Organisation Concise International Chemical Assessment, Geneva, Document 55 cited; Available from:
    • Polychlorinated biphenyls: human health aspects 2003, WHO, World Health Organisation Concise International Chemical Assessment, Geneva, Document 55 cited; Available from: http://www.inchem.org/documents/cicads/cicads/cicad55.htm.
    • (2003) Polychlorinated biphenyls: human health aspects
  • 75
    • 33645634241 scopus 로고    scopus 로고
    • Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells
    • Wiemels J., Wiencke J.K., Varykoni A., Smith M.T. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 1999, 12(6):467-475.
    • (1999) Chem Res Toxicol , vol.12 , Issue.6 , pp. 467-475
    • Wiemels, J.1    Wiencke, J.K.2    Varykoni, A.3    Smith, M.T.4
  • 76
    • 0035664430 scopus 로고    scopus 로고
    • Levels of persistent organic pollutants in several child day care centers
    • Wilson N.K., Chuang J.C., Lyu C. Levels of persistent organic pollutants in several child day care centers. J Expo Anal Environ Epidemiol 2001, 11(6):449-458.
    • (2001) J Expo Anal Environ Epidemiol , vol.11 , Issue.6 , pp. 449-458
    • Wilson, N.K.1    Chuang, J.C.2    Lyu, C.3
  • 77
    • 35448982010 scopus 로고    scopus 로고
    • Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster V79 cells
    • Zettner M.A., Flor S., Ludewig G., Wagner J., Robertson L.W., Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster V79 cells. Toxicol Sci 2007, 100(1):88-98.
    • (2007) Toxicol Sci , vol.100 , Issue.1 , pp. 88-98
    • Zettner, M.A.1    Flor, S.2    Ludewig, G.3    Wagner, J.4    Robertson, L.W.5    Lehmann, L.6


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