Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model

Toxicological Sciences

Volumn 79, Issue 1, 2004, Pages 41-46

  Espandiari, Parvaneh ^a   Glauert, Howard P ^a   Lehmler, Hans Joachim ^a   Lee, Eun Y ^a   Srinivasan, Cidambi ^a   Robertson, Larry W ^a,b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Altered hepatic foci; Hepatocarcinogenesis; Initiation; PCB 3; Polychlorinated biphenyls (PCBs); Solt Farber

Indexed keywords

CARBON TETRACHLORIDE; CARCINOGEN; DIETHYLNITROSAMINE; DRUG VEHICLE; GAMMA GLUTAMYLTRANSFERASE; N (2 FLUORENYL)ACETAMIDE; POLYCHLORINATED BIPHENYL; QUINONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEEDING; HYDROXYLATION; IN VIVO STUDY; INTUBATION; LIVER CELL; LIVER STRUCTURE; METABOLIC ACTIVATION; NONHUMAN; OXIDATION; RAT; RAT STRAIN; RODENT;

2-ACETYLAMINOFLUORENE; ADENOMA, LIVER CELL; ADMINISTRATION, ORAL; ANIMALS; BIPHENYL COMPOUNDS; BODY WEIGHT; CARBON TETRACHLORIDE; CARCINOGENS; DIETHYLNITROSAMINE; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; GAMMA-GLUTAMYLTRANSFERASE; HYDROXYLATION; INJECTIONS, INTRAPERITONEAL; INTUBATION, INTRATRACHEAL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MODELS, BIOLOGICAL; ORGAN SIZE; QUINONES; RATS; RATS, INBRED F344; TIME FACTORS;

ANIMALIA; RODENTIA;

EID: 2442715155     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh097     Document Type: Article

References (44)

1. Amaro, A. R., Oakley, G. G., Bauer, U., Spielmann, H. P., and Robertson, L. W. (1996). Metabolic activation of PCBs to quinones: Reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase. Chem. Res. Toxicol. 9, 623-629.
2. ATSDR (Agency for Toxic Substances and Disease Registry, 2000). In Toxicological Profile for Polychlorinated Biphenyls (PCBs). U.S. Department of Health Services, Public Health Service. Reproduced by U.S. Department of Commerce, National Technical Information Service, Springfield, VA.
3. Bandiera, S. (2001). Cytochrome P450 enzymes as biomarkers of PCB exposure and modulators of toxicity. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson and L. G. Hansen, Eds.), pp. 185-192. University Press of Kentucky, Lexington, KY.
4. Campbell, H. A., Pitot, H. C., Porter, V. R., and Laishes, B. A. (1982). Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver. Cancer Res. 42, 465-472.
5. Campbell, H. A., Xu, Y. D., Hanigan, M. H., and Pitot, H. C. (1986). Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver. J. Natl. Cancer Inst. 76, 751-767.
6. Crawford, A., and Safe, S. (1979). 4-Chlorobiphenyl metabolism: The effects of chemical inducers. Gen. Pharmacol. 10, 227-231.
7. Espandiari, P., Glauert, H. P., Lehmler, H. J., Lee, E. Y., Srinivasan, C., and Robertson, L. W. (2003). Polychlorinated biphenyls as initiators in liver carcinogenesis: Resistant hepatocyte model. Toxicol. Appl. Pharmacol. 186, 55-62.
8. Espandiari, P., Glauert, H. P., and Robertson, L. W. (2002). Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol. Sci. 66, 310.
9. Glauert, H. P., Robertson, L. W., and Silberhorn, E. M. (2001). PCBs and tumor promotion. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson and L. G. Hansen, Eds.), pp. 355-371. University Press of Kentucky, Lexington, KY.
10. Hansen, L. G. (1999). The Ortho Side of PCBs: Occurrence and Disposition. Kluwer Academic Publishers, Boston.
11. James, M. O. (2001). Polychlorinated biphenyls: Metabolism and metabolites. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson and L. G. Hansen, Eds.), pp. 35-46. University Press of Kentucky, Lexington, KY.
12. Laconi, E., Tessitore, L., Milia, G., Yusuf, A., Sarma, D. S., Todde, P., and Pani, P. (1995). The enhancing effect of fasting/refeeding on the growth of nodules selectable by the resistant hepatocyte model in rat liver. Carcinogenesis 16, 1865-1869.
13. Lang, V. (1992). Polychlorinated biphenyls in the environment. J. Chromatogr. 595, 1-43.
14. Letcher, R. J., Klasson-Wehler, E., and Bergman, A. (2000). Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls. In New Types of Persistent Halogenated Compounds (J. Paasivirta, Ed.), Vol. 3, Part K, pp. 317-357. Springer-Verlag, Berlin.
15. Ludewig, G. (2001). Cancer initiation by PCBs. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson and L. G. Hansen, Eds.), pp. 337-354. University Press of Kentucky, Lexington, KY.
16. Maronpot, R. R., Montgomery, C. A., Jr., Boorman, G. A., and McConnell, E. E. (1986). National Toxicology Program nomenclature for hepatoproliferative lesions of rats. Toxicol. Pathol. 14, 263-273.
17. Mayes, B. A., McConnell, E. E., Neal, B. H., Brunner, M. J., Hamilton, S. B., Sullivan, T. M., Peters, A. C., Ryan, M. J., Toft, J. D., Singer, A. W., et al. (1998). Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol. Sci. 41, 62-76.
18. McLean, M. R., Bauer, U., Amaro, A. R., and Robertson, L. W. (1996a). Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem. Res. Toxicol. 9, 158-164.
19. 32P-postlabeling technique. Chem. Res. Toxicol. 9, 165-171.
20. McLean, M. R., Twaroski, T. P., and Robertson, L. W. (2000). Redox cycling of 2-(x′-mono, -di, -trichlorophenyl)- 1, 4-benzoquinones, oxidation products of polychlorinated biphenyls. Arch. Biochem. Biophys. 376, 449-455.
21. Miller, S. M., Green, M. L., Depinto, J. V., and Hornbuckle, K. C. (2001). Results from the Lake Michigan Mass Balance study: Concentrations and fluxes of atmospheric polychlorinated biphenyls and trans-nonachlor. Environ. Sci. Technol. 35, 278-285.
22. Mills, R. A., Millis, C. D., Dannan, G. A., Guengerich, F. P., and Aust, S. D. (1985). Studies on the structure-activity relationships for the metabolism of polybrominated biphenyls by rat liver microsomes. Toxicol. Appl. Pharmacol. 78, 96-104.
23. Narbonne, J. F., and Daubeze, M. (1980). In vitro binding of hexachlorobiphenyl to DNA and proteins. Toxicology 16, 173-175.
24. Oakley, G. G., Devanaboyina, U., Robertson, L. W., and Gupta, R. C. (1996a). Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB-induced oxidative stress in breast cancer. Chem. Res. Toxicol. 9, 1285-1292.
25. Oakley, G. G., Robertson, L. W., and Gupta, R. C. (1996b). Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling. Carcinogenesis 17, 109-114.
26. Pereg, D., Robertson, L. W., and Gupta, R. C. (2002). DNA adduction by polychlorinated biphenyls: Adducts derived from hepatic microsomal activation and from synthetic metabolites. Chem. Biol. Interact. 139, 129-144.
27. Pereg, D., Tampal, N., Espandiari, P., and Robertson, L. W. (2001). Distribution and macromolecular binding of benzo[a]pyrene and two polychlorinated biphenyl congeners in female mice. Chem. Biol. Interact. 137, 243-258.
28. Pessah, I. N., and Wong, P. W. (2001). Etiology of PCB neurotoxicity: From molecules to cellular dysfunction. In PCBs: Recent Advances in Environmental Toxicology and Health Effects (L. W. Robertson and L. G. Hansen, Eds.), pp. 179-184. University Press of Kentucky, Lexington, KY.
29. Robertson, L. W., and Hansen, L. G., Eds. (2001). PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Press of Kentucky, Lexington, KY.
30. Safe, S. (1984). Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): Biochemistry, toxicology, and mechanism of action. Crit. Rev. Toxicol. 13, 319-395.
31. Safe, S. (1994). Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev. Toxicol. 24, 87-149.
32. Semple-Roberts, E., Hayes, M. A., Armstrong, D., Becker, R. A., Racz, W. J., and Farber, E. (1987). Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int. J. Cancer 40, 643-645.
33. Shimada, T., Imai, Y., and Sato, R. (1981). Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450. Chem. Biol. Interact. 38, 29-44.
34. Silberhorn, E. M., Glauert, H. P., and Robertson, L. W. (1990). Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit. Rev. Toxicol. 20, 440-496.
35. Solt, D. B., Medline, A., and Farber, E. (1977). Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am. J. Pathol. 88, 595-618.
36. Srinivasan, A., Lehmler, H. J., Robertson, L. W., and Ludewig, G. (2001). Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Toxicol. Sci. 60, 92-102.
37. Srinivasan, A., Robertson, L. W., and Ludewig, G. (2002). Sulfhydryl binding and topoisomerase inhibition by PCB metabolites. Chem. Res. Toxicol. 15, 497-505.
38. Sundstrom, G., Hutzinger, O., and Safe, S. (1976). The metabolism of chlorobiphenyls: A review. Chemosphere 5, 267-298.
39. Tampal, N., Myers, S., and Robertson, L. W. (2003). Binding of polychlorinated biphenyls/metabolites to hemoglobin. Toxicol. Lett. 142, 53-60.
40. Thakker, D. R., Yagi, H., Levin, W., Wood, A. W., Conney, A. H., and Jerina, D. M. (1985). Polycyclic aromatic hydrocarbons: Metabolic activation to ultimate carcinogens. In Bioactivation of Foreign Compounds (M. W. Anders, Ed.), pp. 177-242. Academic Press, Orlando, FL.
41. Tsuda, H., Lee, G., and Farber, E. (1980). Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res. 40, 1157-1164.
42. Wiencke, J. K., Thurston, S. W., Kelsey, K. T., Varkonyi, A., Wain, J. C., Mark, E. J., and Christiani, D. C. (1999). Early age at smoking initiation and tobacco carcinogen damage in the lung. J. Natl. Cancer Inst. 91, 614-619.
43. Xu, Y. H., Dragan, Y. P., Campbell, H. A., and Pitot, H. C. (1998). STEREO: A program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents. Comput. Methods Programs Biomed. 56, 49-63.
44. Yu, D., Berlin, J. A., Penning, T. M., and Field, J. (2002). Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53. Chem. Res. Toxicol. 15, 832-842.