Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk of arsenic-associated carotid atherosclerosis

Toxicology and Applied Pharmacology

Volumn 216, Issue 1, 2006, Pages 168-175

  Wu, Meei Maan ^a,b   Chiou, Hung Yi ^a   Hsueh, Yu Mei ^a   Hong, Chi Tzong ^c   Su, Che Long ^d   Chang, Shu Feng ^d   Huang, Wen Ling ^a   Wang, Hui Ting ^a   Wang, Yuan Hung ^a   Hsieh, Yi Chen ^a   Chen, Chien Jen ^e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d Division of Neurology   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Arsenic; Atherosclerosis; Biomethylation; Homocysteine; Risk factors

Indexed keywords

ARSENIC; ARSENIC ACID; ARSENIC TRIOXIDE; CACODYLIC ACID; HOMOCYSTEINE; METHANEARSONIC ACID; WELL WATER;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE EXACERBATION; EXPOSURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOCYSTINURIA; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NUTRITION; RISK; URINE;

AGE FACTORS; AGED; AGED, 80 AND OVER; ARSENIC; ARSENICALS; ATHEROSCLEROSIS; CACODYLIC ACID; CAROTID ARTERY DISEASES; CHOLESTEROL, LDL; FEMALE; HOMOCYSTEINE; HUMANS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; ODDS RATIO; RISK FACTORS; SEX FACTORS; TIME FACTORS; WATER POLLUTION; WATER SUPPLY;

EID: 33748747684     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.05.005     Document Type: Article

References (58)

1. Ahmad S., Kitchin K.T., and Cullen W.R. Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin. Toxicol. Lett. 133 (2002) 47-57
2. Barchowsky A., Dudek E.J., Treadwell M.D., and Wetterhahn K.E. Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radic. Biol. Med. 21 (1996) 783-790
3. Barchowsky A., Klei L.R., Dudek E.J., Swartz H.M., and James P.E. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite. Free Radic. Biol. Med. 27 (1999) 1405-1412
4. Buchet J.P., and Lauwerys R. Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol. Biochem. Pharmacol. 37 (1988) 3149-3153
5. Bunderson M., Coffin J.D., and Beall H.D. Arsenic induces peroxynitrite generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. Toxicol. Appl. Pharmacol. 184 (2002) 11-18
6. Bunderson M., Brooks D.M., Walker D.L., Rosenfeld M.E., Coffin J.D., and Beall H.D. Arsenic exposure exacerbates atherosclerotic plaque formation and increases nitrotyrosine and leukotriene biosynthesis. Toxicol. Appl. Pharmacol. 201 (2004) 32-39
7. Chao C.L., Tsai H.H., Lee C.M., Hsu S.M., Kao J.T., Chien K.L., Sung F.C., and Lee Y.T. The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis. Atherosclerosis 147 (1999) 379-386
8. Chen C.J., Chiou H.Y., Chiang M.H., Lin L.J., and Tai T.Y. Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure. Arterioscler. Thromb. Vasc. Biol. 16 (1996) 504-510
9. Chen Y.C., Su H.J., Guo Y.L., Hsueh Y.M., Smith T.J., Ryan L.M., Lee M.S., and Christiani D.C. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control 14 (2003) 303-310
10. Chen C.L., Hsu L.I., Chiou H.Y., Hsueh Y.M., Chen S.Y., Wu M.M., and Chen C.J. Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. JAMA 292 (2004) 2984-2990
11. Chiou H.Y., Hsueh Y.M., Hsieh L.L., Hsu L.I., Hsu Y.H., Hsieh F.I., Wei M.L., Chen H.C., Yang H.T., Leu L.C., Chu T.H., Chen-Wu C., Yang M.H., and Chen C.J. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mutat. Res. 386 (1997) 197-207
12. Chiou H.Y., Huang W.I., Su C.L., Chang S.F., Hsu Y.H., and Chen C.J. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 28 (1997) 1717-1723
13. Chiou H.Y., Chiou S.T., Hsu Y.H., Chou Y.L., Tseng C.H., Wei M.L., and Chen C.J. Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan. Am. J. Epidemiol. 153 (2001) 411-418
14. Collaboration H.S. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288 (2002) 2015-2022
15. Cullen W.R., McBride B.C., Pickett A.W., and Reglinski J. The wood preservative chromated copper arsenate is a substrate for trimethylarsine biosynthesis. Appl. Environ. Microbiol. 47 (1984) 443-444
16. Del Razo L.M., Garcia-Vargas G.G., Vargas H., Albores A., Gonsebatt M.E., Montero R., Ostrosky-Wegman P., Kelsh M., and Cebrian M.E. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism. A pilot study. Arch. Toxicol. 71 (1997) 211-217
17. Del Razo L.M., Quintanilla-Vega B., Brambila-Colombres E., Calderon-Aranda E.S., Manno M., and Albores A. Stress proteins induced by arsenic. Toxicol. Appl. Pharmacol. 177 (2001) 132-148
18. Drobna Z., Waters S.B., Devesa V., Harmon A.W., Thomas D.J., and Styblo M. Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. Toxicol. Appl. Pharmacol. 207 (2005) 147-159
19. Durand P., Prost M., and Blache D. Folate deficiencies and cardiovascular pathologies. Clin. Chem. Lab. Med. 36 (1998) 419-429
20. Engel R.R., and Smith A.H. Arsenic in drinking water and mortality from vascular disease: an ecologic analysis in 30 counties in the United States. Arch. Environ. Health 49 (1994) 418-427
21. Finkelstein J.D., Kyle W., and Harris B.J. Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch. Biochem. Biophys. 146 (1971) 84-92
22. Fruchart J.C., Nierman M.C., Stroes E.S., Kastelein J.J., and Duriez P. New risk factors for atherosclerosis and patient risk assessment. Circulation 109 (2004) III15-III19
23. Gebel T.W. Arsenic methylation is a process of detoxification through accelerated excretion. Int. J. Hyg. Environ. Health 205 (2002) 505-508
24. Hackam D.G., and Anand S.S. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA 290 (2003) 932-940
25. Handy D.E., Zhang Y., and Loscalzo J. Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J. Biol. Chem. 280 (2005) 15518-15525
26. Hsueh Y.M., Chiou H.Y., Huang Y.L., Wu W.L., Huang C.C., Yang M.H., Lue L.C., Chen G.S., and Chen C.J. Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Cancer Epidemiol. Biomark. Prev. 6 (1997) 589-596
27. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 (2001) 249-261
28. Kitchin K.T., and Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol. Lett. 137 (2003) 3-13
29. Kolling K., Ndrepepa G., Koch W., Braun S., Mehilli J., Schomig A., and Kastrati A. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease. Am. J. Cardiol. 93 (2004) 1201-1206
30. Lawrence de Koning A.B., Werstuck G.H., Zhou J., and Austin R.C. Hyperhomocysteinemia and its role in the development of atherosclerosis. Clin. Biochem. 36 (2003) 431-441
31. Lee P.C., Ho I.C., and Lee T.C. Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. Toxicol. Sci. 85 (2005) 541-550
32. Lewis D.R., Southwick J.W., Ouellet-Hellstrom R., Rench J., and Calderon R.L. Drinking water arsenic in Utah: a cohort mortality study. Environ. Health Perspect.. 107 (1999) 359-365
33. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
34. Lin J.S., Shen M.C., Cheng W.C., Tsay W., Wang Y.C., Lin B.B., and Hung M.H. Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese. Br. J. Haematol. 117 (2002) 159-163
35. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., and Kligerman A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14 (2001) 355-361
36. Matthias D., Becker C.H., Riezler R., and Kindling P.H. Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine. Atherosclerosis 122 (1996) 201-216
37. Nordstrom K. Worldwide occurrences of arsenic in ground water. Science 296 (2002) 2143-2144
38. Petrick J.S., Ayala-Fierro F., Cullen W.R., Carter D.E., and Vasken Aposhian H. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes. Toxicol. Appl. Pharmacol. 163 (2000) 203-207
39. Pi J., Yamauchi H., Kumagai Y., Sun G., Yoshida T., Aikawa H., Hopenhayn-Rich C., and Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ. Health Perspect. 110 (2002) 331-336
40. Schlesselman J.J., and Stolley P.D. Case-Control Studies: Design, Conduct, Analysis (1982), Oxford University Press, New York
41. Selhub J., Jacques P.F., Wilson P.W., Rush D., and Rosenberg I.H. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270 (1993) 2693-2698
42. Simeonova P.P., and Luster M.I. Arsenic and atherosclerosis. Toxicol. Appl. Pharmacol. 198 (2004) 444-449
43. Simeonova P.P., Hulderman T., Harki D., and Luster M.I. Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice. Environ. Health Perspect. 111 (2003) 1744-1748
44. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., and Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74 (2000) 289-299
45. Thompson D.J. A chemical hypothesis for arsenic methylation in mammals. Chem. Biol. Interact. 88 (1993) 14-89
46. Tseng C.H., Chong C.K., Chen C.J., and Tai T.Y. Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan. Atherosclerosis 120 (1996) 125-133
47. Tseng C.H., Huang Y.K., Huang Y.L., Chung C.J., Yang M.H., Chen C.J., and Hsueh Y.M. Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Toxicol. Appl. Pharmacol. 206 (2005) 299-308
48. U.S.PHS. Toxicological Profile for Arsenic (1989), Public Health Service, Washington, DC
49. Vahter, M., 2002. Mechanisms of arsenic biotransformation. Toxicology 181-182, 211-217.
50. Wang T.S., and Huang H. Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells. Mutagenesis 9 (1994) 253-257
51. Wang C.H., Jeng J.S., Yip P.K., Chen C.L., Hsu L.I., Hsueh Y.M., Chiou H.Y., Wu M.M., and Chen C.J. Biological gradient between long-term arsenic exposure and carotid atherosclerosis. Circulation 105 (2002) 1804-1809
52. Wang H., Jiang X., Yang F., Gaubatz J.W., Ma L., Magera M.J., Yang X., Berger P.B., Durante W., Pownall H.J., and Schafer A.I. Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood 101 (2003) 3901-3907
53. WHO. Environmental Health Criteria 18: Arsenic (1981), World Health Organization, Geneva
54. Wu M.M., Chiou H.Y., Wang T.W., Hsueh Y.M., Wang I.H., Chen C.J., and Lee T.C. Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ. Health Perspect. 109 (2001) 1011-1017
55. Wu M.M., Chiou H.Y., Ho I.C., Chen C.J., and Lee T.C. Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects. Environ. Health Perspect. 111 (2003) 1429-1438
56. Yamanaka K., and Okada S. Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ. Health Perspect. 102 Suppl 3 (1994) 37-40
57. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., and James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 275 (2000) 29318-29323
58. Yu R.C., Hsu K.H., Chen C.J., and Froines J.R. Arsenic methylation capacity and skin cancer. Cancer Epidemiol. Biomark. Prev. 9 (2000) 1259-1262