The controversy about a possible relationship between mobile phone use and cancer;A controvérsia sobre a possível relação entre o uso do telefone celular e câncer

Ciencia e Saude Coletiva

Volumn 15, Issue 5, 2010, Pages 2415-2430

  Kundi, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Acoustic neuroma; Brain tumors; Glioma; Meningioma; Mobile phones; Risk assessment

Indexed keywords

EID: 77957234713     PISSN: 14138123     EISSN: 16784561     Source Type: Journal    
DOI: 10.1590/S1413-81232010000500016     Document Type: Review

References (82)

1. Ahlbom A, Green A, Kheifets L, Savitz D, Swerdlow A. Epidemiology of health effects of radiofrequency exposure. Environ Health Perspect 2004; 112:1741-1754.
2. Krewski D, Byus C, Glickman B, Lotz W, Mandeville R, McBride M, Prato FS, Weaver DF. Recent advances in research on radio-frequency fields and health. J Toxicol Environ Health B Crit Rev 2001; 4(1):145-159.
3. Kundi M. Mobile phone use and cancer. Occup Environ Med 2004; 61(6):560-570, 487.
4. Kundi M. Causality and the interpretation of epidemiologic evidence. Environ Health Perspect 2006; 114:969-974.
5. Hardell L, Hallquist A, Hansson Mild K, Carlberg M, Gertzén H, Schildt E, Dahlqvist A. No association between the use of cellular or cordless telephones and salivary gland tumours. Occup Environ Med 2004; 61(8):675-679.
6. Lönn S, Ahlbom A, Christensen H, Johansen C, Schüz J, Edström S, Henriksson G, Lundgren J, Wennerberg J, Feychting M. Mobile phone use and risk of parotid gland tumor. Am J Epidemiol 2006; 164(7):637-643.
7. Sadetzki S, Chetrit A, Jarus-Hakak A, Cardis E, Deutch Y, Duvdevani S, Zultan A, Novikov I, Freedman L, Wolf M. Cellular phone use and risk of benign and malignant parotid gland tumors-a nationwide case-control study. Am J Epidemiol 2008; 167(4):457-467.
8. Stang A, Anastassiou G, Ahrens W, Bromen K, Bornfeld N, Jöckel K. The possible role of radiofrequency radiation in the development of uveal melanoma. Epidemiology 2001; 12(1):7-12.
9. Hardell L, Eriksson M, Carlberg M, Sundström C, Hansson Mild K. Use of cellular or cordless telephones and the risk for non-Hodgkin's lymphoma. Int Arch Occup Environ Health 2005; 78(8):625-632.
10. Linet M, Taggart T, Severson R, Cerhan J, Cozen W, Hartge P, Colt J. Cellular telephones and non-Hodgkin lymphoma. Int J Cancer 2006; 119(10):2382- 2388.
11. Warren H, Prevatt A, Daly K, Antonelli P. Cellular tele-phone use and risk of intratemporal facial nerve tumor. Laryngoscope 2003; 113(4):663-667.
12. Hardell L, Carlberg M, Ohlson C, Westberg H, Eriksson M, Hansson Mild K. Use of cellular and cordless tele-phones and risk of testicular cancer. Int J Androl 2007; 30(2):115-122.
13. Dreyer N, Loughlin J, Rothman K. Cause-specific mortality in cellular telephone users. JAMA 1999; 282(19):1814-1816.
14. Hardell L, Näsman A, Påhlson A, Hallquist A, Hansson Mild K. Use of cellular telephones and the risk for brain tumours: a case-control study. Int J Oncol 1999; 15(1):113-116.
15. Hardell L, Nasman A, Påhlson A, Hallquist A. Casecontrol study on radiology work, medical X-ray investigations, and use of cellular telephones as risk factors for brain tumors. MedGenMed 2000; 2(2):E2.
16. Hardell L, Hansson Mild K, Påhlson A, Hallquist A. Ionizing radiation, cellular telephones and the risk for brain tumours. Eur J Cancer Prev 2001; 10(6):523- 529.
17. Muscat J, Malkin M, Thompson S, Shore R, Stellman S, McRee D, Neugut AI, Wynder EL. Handheld cellular telephone use and risk of brain cancer. JAMA 2000; 284(23):3001-3007.
18. Inskip P, Tarone R, Hatch E, Wilcosky T, Shapiro W, Selker R, Fine HA, Black PM, Loeffler JS, Linet MS. Cellular-telephone use and brain tumors. N Engl J Med 2001; 344(2):79-86.
19. Johansen C, Boice J Jr, McLaughlin J, Olsen J. Cellular telephones and cancer-a nationwide cohort study in Denmark. J Natl Cancer Inst 2001; 93(3):203- 207.
20. Schüz J, Jacobsen R, Olsen J, Boice J Jr, McLaughlin J, Johansen C. Cellular telephone use and cancer risk: update of a nationwide Danish cohort. J Natl Cancer Inst 2006; 98(23):1707-1713.
21. Auvinen A, Hietanen M, Luukkonen R, Koskela R. Brain tumors and salivary gland cancers among cellular tele-phone users. Epidemiology 2002; 13(3):356-359.
22. Muscat J, Malkin M, Shore R, Thompson S, Neugut A, Stellman S, Bruce J. Handheld cellular telephones and risk of acoustic neuroma. Neurology 2002; 58(8):1304-1306.
23. Hardell L, Hallquist A, Hansson Mild K, Carlberg M, Påhlson A, Lilja A. Cellular and cordless telephones and the risk for brain tumours. Eur J Cancer Prev 2002; 11(4):377-386.
24. Hardell L, Hansson Mild K, Carlberg M. Case-control study on the use of cellular and cordless phones and the risk for malignant brain tumours. Int J Radiat Biol 2002; 78(10):931-936.
25. Christensen H, Schüz J, Kosteljanetz M, Poulsen H, Thomsen J, Johansen C. Cellular telephone use and risk of acoustic neuroma. Am J Epidemiol 2004; 159(3):277-283.
26. Lönn S, Ahlbom A, Hall P, Feychting M. Mobile phone use and the risk of acoustic neuroma. Epidemiology 2004; 15(6):653-659.
27. Christensen H, Schüz J, Kosteljanetz M, Poulsen H, Boice J Jr, McLaughlin J, Johansen C. Cellular telephones and risk for brain tumors: a populationbased, incident case-control study. Neurology 2005; 64(7):1189-1195.
28. Hardell L, Carlberg M, Hansson Mild K. Case-control study of the association between the use of cellular and cordless telephones and malignant brain tumors diag-nosed during 2000-2003. Environ Res 2006; 100(2):232-241.
29. Hardell L, Carlberg M, Hansson Mild K. Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003. Neuroepidemiology 2005; 25(3):120-128.
30. Lönn S, Ahlbom A, Hall P, Feychting M. Long-term mobile phone use and brain tumor risk. Am J Epidemiol 2005; 161(6):526-535.
31. Schoemaker M, Swerdlow A, Ahlbom A, Auvinen A, Blaasaas K, Cardis E, Christensen HC, Feychting M, Hepworth SJ, Johansen C, Klaeboe L, Lönn S, McKinney PA, Muir K, Raitanen J, Salminen T, Thomsen J, Tynes T. Mobile phone use and risk of acoustic neuroma: results of the Interphone casecontrol study in five North European countries. Br J Cancer 2005; 93(7):842-848.
32. Hepworth S, Schoemaker M, Muir K, Swerdlow A, van Tongeren, MJA, McKinney PA. Mobile phone use and risk of glioma in adults: case-control study. BMJ 2006; 332(7546):883-887.
33. Schüz J, Böhler E, Berg G, Schlehofer B, Hettinger I, Schlaefer K, Wahrendorf J, Kunna-Grass K, Blettner M. Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol 2006; 163(6):512-520.
34. Klaeboe L, Blaasaas K, Tynes T. Use of mobile phones in Norway and risk of intracranial tumours. Eur J Cancer Prev 2007; 16(2):158-164.
35. Takebayashi T, Akiba S, Kikuchi Y, Taki M, Wake K, Watanabe S, Yamaguchi N. Mobile phone use and acoustic neuroma risk in Japan. Occup Environ Med 2006; 63(12):802-807.
36. Lahkola A, Auvinen A, Raitanen J, Schoemaker M, Christensen H, Feychting M, Johansen C, Klaeboe L, Lönn S, Swerdlow AJ, Tynes T, Salminen T. Mobile phone use and risk of glioma in 5 North European countries. Int J Cancer 2007; 120(8):1769-1775.
37. Schlehofer B, Schlaefer K, Blettner M, Berg G, Böhler E, Hettinger I, Kunna-Grass K, Wahrendorf J, Schüz J; Interphone Study Group. Environmental risk factors for sporadic acoustic neuroma (Interphone Study Group, Germany). Eur J Cancer 2007; 43(11):1741-1747.
38. Hours M, Bernard M, Montestrucq L, Arslan M, Bergeret A, Deltour I, Cardis E. Cell phones and risk of brain and acoustic nerve tumours: the French INTERPHONE case-control study [in French]. Rev Epidemiol Sante Publique 2007; 55(5):321-332.
39. Takebayashi T, Varsier N, Kikuchi Y, Wake K, Taki M, Watanabe S, Akiba S, Yamaguchi N. Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case-control study. Br J Cancer 2008; 98(3):652-659.
40. Lahkola A, Salminen T, Raitanen J, Heinävaara S, Schoemaker M, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Swerdlow AJ, Tynes T, Auvinen A. Meningioma and mobile phone use-a collaborative case-control study in five North European countries. Int J Epidemiol 2008. 37(6):1304-1313.
41. Mohyuddin A, Vokurka E, Evans D, Ramsden R, Jackson A. Is clinical growth index a reliable predictor of tumour growth in vestibular schwannomas? Clin Otolaryngol Allied Sci 2003; 28(2):85-90.
42. Wrensch M, Minn Y, Chew T, Bondy M, Berger M. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 2002; 4(4):278-299.
43. Kleihues P, Cavenee WK, editors. World Health Organization Classification of Tumours. Pathology and Genetics: Tumours of the Nervous System. Lyon: International Agency for Research on Cancer; 2000.
44. Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol 2006; 2(9):494-503.
45. Umansky F, Shoshan Y, Rosnethal G, Fraifeld S, Spektor S. Radiation-induced meningioma. Neurosurg Focus [serial on the Internet] 2008; 24(5):[about 1 p.]. Available from:http://thejns.org/doi/pdf/10.3171/FOC/2008/24/5/E7
46. Kranzinger M, Jones N, Rittinger O, Pilz P, Piotrowski W, Manzl M, Galvan G, Kogelnik HD. Malignant glioma as a secondary malignant neoplasm after radiation therapy for cranio-pharyngioma: report of a case and review of reported cases. Onkologie 2001; 24(1):66-72.
47. Sadetzki S, Chetrit A, Freedman L, Stovall M, Modan B, Novikov I. Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiat Res 2005; 163(4):424-432.
48. Cahan W, Woodard H, Higinbotham N, Stewart F, Coley B. Sarcoma arising in irradiated bone. Report of eleven cases. Cancer 1948; 1:3-29.
49. Hardell L, Carlberg M, Hansson Mild K. Pooled analysis of two case-control studies on use of cellular and cord-less telephones and the risk for malignant brain tumours diagnosed in 1997-2003. Int Arch Occup Environ Health 2006; 79(8):630-639.
50. Hardell L, Carlberg M, Hansson Mild K. Pooled analysis of two case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997-2003. Int J Oncol 2006; 28(2):509-518.
51. Cardis E, Richardson L, Deltour I, Armstrong B, Feychting M, Johansen C, Kilkenny M, McKinney P, Modan B, Sadetzki S, Schüz J, Swerdlow A, Vrijheid M, Auvinen A, Berg G, Blettner M, Bowman J, Brown J, Chetrit A, Christensen HC, Cook A, Hepworth S, Giles G, Hours M, Iavarone I, Jarus-Hakak A, Klaeboe L, Krewski D, Lagorio S, Lönn S, Mann S, McBride M, Muir K, Nadon L, Parent ME, Pearce N, Salminen T, Schoemaker M, Schlehofer B, Siemiatycki J, Taki M, Takebayashi T, Tynes T, van Tongeren M, Vecchia P, Wiart J, Woodward A, Yamaguchi N. The INTERPHONE study: design, epidemiological methods, and description of the study population. Eur J Epidemiol 2007; 22(9):647-664.
52. Lönn S, Forssén U, Vecchia P, Ahlbom A, Feychting M. Output power levels from mobile phones in different geo-graphical areas; implications for exposure assessment. Occup Environ Med 2004; 61:769-772.
53. Söderqvist F, Carlberg M, Hardell L. Use of wireless tele-phones and self-reported health symptoms: a population-based study among Swedish adolescents aged 15-19 years. Environ Health [serial on the Internet] 2008 [cited 2008 May 21]. Available from: http://www.ehjournal.net/content/pdf/1476-069X-7-18.pdf
54. Berg G, Schüz J, Samkange-Zeeb F, Blettner M. Assessment of radiofrequency exposure from cellular telephone daily use in an epidemiological study: German validation study of the international case-control study of cancers of the brain-INTERPHONE- study. J Expo Anal Environ Epidemiol 2005; 15(3):217-224.
55. Vrijheid M, Cardis E, Armstrong B, Auvinen A, Berg G, Blaasaas K, Brown J, Carroll M, Chetrit A, Christensen HC, Deltour I, Feychting M, Giles GG, Hepworth SJ, Hours M, Iavarone I, Johansen C, Klaeboe L, Kurttio P, Lagorio S, Lönn S, McKinney PA, Montestrucq L, Parslow RC, Richardson L, Sadetzki S, Salminen T, Schüz J, Tynes T, Woodward A; Interphone Study Group. Validation of short term recall of mobile phone use for the Interphone study. Occup Environ Med 2006; 63(4):237-243.
56. Vrijheid M, Deltour I, Krewski D, Sanchez M, Cardis E. The effects of recall errors and of selection bias in epi-demiologic studies of mobile phone use and cancer risk. J Expo Sci Environ Epidemiol 2006; 16(4):371-384.
57. Hardell L, Hansson Mild K, Carlberg M, Söderqvist F. Tumour risk associated with use of cellular telephones or cordless desktop telephones. World J Surg Oncol 2006; 4:74-83.
58. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008.
59. Kundi M, Hansson Mild K, Hardell L, Mattsson M. Mobile telephones and cancer-a review of epidemiological evi-dence. J Toxicol Environ Health B Crit Rev 2004; 7(5):351-384.
60. Cardis E, Deltour I, Mann S, Moissonnier M, Taki M, Varsier N, Wake K, Wiart J. Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol 2008; 53:2771-2783.
61. Hardell L, Carlberg M, Hansson Mild K. Methodological aspects of epidemiological studies on the use of mobile phones and their association with brain tumors. Open Environ Sci 2008; 2:54-61.
62. Lönn S. Mobile phone use and risk of intra-cranial tumors [doctoral thesis]. Stockholm: Karolinska Institutet; 2004.
63. Chiabrera A, Bianco B, Moggia E, Kaufman J. Zeeman- Stark modeling of the RF EMF interaction with ligand binding. Bioelectromagnetics 2000; 21:312-324.
64. Vanderstraeten J, Verschaeve L. Gene and protein expres-sion following exposure to radiofrequency fields from mobile phones. Environ Health Perspect 2008; 116:1131-1135.
65. Karinen A, Heinävaara S, Nylund R, Leszczynski D. Mobile phone radiation might alter protein expression in human skin. BMC Genomics [serial on the Internet] 2008 [cited 2008 Feb 11]. Available from: http://www.biomedcentral.com/content/pdf/1471-2164-9-77.pdf
66. Lai H, Singh N. Melatonin and a spin-trap compound blocked radiofrequency radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics 1997; 18:446-454.
67. Phelan A, Lange D, Kues H, Lutty G. Modification of mem-brane fluidity in melanin containing cells by low level microwave radiation. Bioelectromagnetics 1992; 13:131-146.
68. Simkó M, Hartwig C, Lantow M, Lupke M, Mattsson M, Rahman Q, Rollwitz J. Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells. Toxicol Lett 2006; 161(1):73-82.
69. Friedman J, Kraus S, Hauptman Y, Schiff Y, Seger R. Mechanism of short-term ERK activation by electro-magnetic fields at mobile phone frequencies. Biochem J 2007; 405(3):559-568.
70. Berg G, Spallek J, Schüz J, Schlehofer B, Böhler E, Schlaefer K, Hettinger I, Kunna-Grass K, Wahrendorf J, Blettner M; Interphone Study Group, Germany. Occupational exposure to radio frequency/micro-wave radiation and the risk of brain tumors: Interphone Study Group, Germany. Am J Epidemiol 2006; 164(6):538-548.
71. Grayson J. Radiation exposure socioeconomic status and brain tumor risk in the U.S. Air Force: a nested case-control study. Am J Epidemiol 1996; 143:480-486.
72. Szmigielski S. Cancer morbidity in subjects occupationally exposed to high frequency (radiofrequency and microwave) electromagnetic radiation. Sci Total Environ 1996; 180:9-17.
73. Thomas T, Stolley P, Stemhagen A, Fontham E, Bleeker M, Stewart P. Brain tumour mortality risk among men with electrical and electronic jobs: a case-control study. J Natl Cancer Inst 1987; 79:233-238.
74. Hardell L, Carlberg M, Hansson Mild K. Use of cellular telephones and brain tumour risk in urban and rural areas. Occup Environ Med 2005; 62(6):390- 394.
75. Kundi M. Comments on the responses of Utteridge (Radiat. Res. 159, 277-278, 2003) to letters about their paper (Radiat. Res. 158, 357-364, 2002). Radiat Res 2003; 160(5):613-614.
76. Adey W, Byus C, Cain C, Higgins R, Jones R, Kean C, Kuster N, MacMurray A, Stagg RB, Zimmerman G. Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats exposed to frequency-modulated microwave fields. Cancer Res 2000; 60(7):1857-1863.
77. Hruby R, Neubauer G, Kuster N, Frauscher M. Study on potential effects of "902-MHz GSM-type Wireless Communication Signals" on DMBA-induced mammary tumours in Sprague-Dawley rats. Mutat Res 2008; 649:34-44.
78. Repacholi M, Basten A, Gebski V, Noonan D, Finnie J, Harris A. Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ MHz electromagnetic fields. Radiat Res 1997; 147:631-640.
79. Shirai T, Ichihara T, Wake K, Watanabe S, Yamanaka Y, Kawabe M, Taki M, Fujiwara O, Wang J, Takahashi S, Tamano S. Lack of promoting effects of chronic exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular system on development of N-ethylnitrosourea-induced central nervous system tumors in F344 rats. Bioelectromagnetics 2007; 28(7):562-572.
80. Lai H, Singh N. Magnetic-field-induced DNA strand breaks in brain cells of the rat. Environ Health Perspect 2004; 112:687-694.
81. Vijayalaxmi, Obe G. Controversial cytogenetic obser-vations in mammalian somatic cells exposed to radio-frequency radiation. Radiat Res 2004; 162:481-496.
82. Vijayalaxmi, Prihoda TJ. Genetic damage in mammalian somatic cells exposed to radiofrequency radiation: a meta-analysis of data from 63 publications (1990-2005). Radiat Res 2008; 169(5):561-574.