Epidemiology of health effects of radiofrequency exposure

Environmental Health Perspectives

Volumn 112, Issue 17, 2004, Pages 1741-1754

  Ahlbom, Anders ^a,b   Green, Adele ^c   Kheifets, Leeka ^d   Savitz, David ^e   Swerdlow, Anthony ^f  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Stockholm Centre of Public Health   (Sweden)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e IL   (United States)

^f INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Electromagnetic fields; EMF; Epidemiology; Health effects; Radiofrequency; RF

Indexed keywords

BRAIN TUMOR; CANCER RISK; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; HUMAN; LEUKEMIA; MOBILE PHONE; OCCUPATIONAL EXPOSURE; POPULATION DISTRIBUTION; PRIORITY JOURNAL; QUALITY CONTROL; RADIOFREQUENCY; REVIEW; RISK ASSESSMENT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TELECOMMUNICATION; TELEVISION;

ADULT; BRAIN NEOPLASMS; CELLULAR PHONE; CHILD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; EPIDEMIOLOGIC STUDIES; HUMANS; LEUKEMIA; OCCUPATIONAL EXPOSURE; RADIO WAVES; RESEARCH DESIGN; RISK ASSESSMENT;

EID: 10944225064     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7306     Document Type: Review

References (98)

1. Ahlbom A, Feychting M. 1999. Re: Use of cellular phones and the risk of brain tumours: a case-control study [Letter]. Int J Oncol 15:1045-1047.
2. Anglesio L, Benedetto A, Bonino A, Colla D, Martire F, Saudino Fusette S, et al. 2001. Population exposure to electromagnetic fields generated by radio base stations: evaluation of the urban background by using provisional model and instrumental measurements. Radiat Prot Dosimetry 97:355-358.
3. Armstrong B, Theriault G, Guenel P, Deadman J, Goldberg M, Heroux P. 1994. Association between exposure to pulsed electromagnetic fields and cancer in electric utility workers in Quebec, Canada, and France. Am J Epidemiol 140:805-820.
4. Auvinen A, Hietanen M, Luukkonen R, Koskela RS. 2002. Brain tumors and salivary gland cancers among cellular telephone users. Epidemiology 13:356-359.
5. Behin A, Hoang-Xuan K, Carpentier AF, Delattre JY. 2003. Primary brain tumours in adults. Lancet 361:323-331.
6. Calle EE, Savitz DA. 1985. Leukemia in occupational groups with presumed exposure to electrical and magnetic fields. N Engl J Med 313(23):1476-1477.
7. Cantor KP, Stewart PA, Brinton LA, Dosemeci M. 1995. Occupational exposures and female breast cancer mortality in the United States. J Occup Environ Med 37:336-348.
8. Chia SE, Chia HP, Tan JS. 2000. Prevalence of headache among handheld cellular telephone users in Singapore: a community study. Environ Health Perspect 108:1059-1062.
9. Christensen HC, Schuz J, Kosteljanetz M, Poulsen HS, Thomsen J, Johansen C. 2004. Cellular telephone use and risk of acoustic neuroma. Am J Epidemiol 159:277-283.
10. Cleary SF, Pasternack BS. 1966. Lenticular changes in microwave workers. A statistical study. Arch Environ Health 12:23-29.
11. Cleary SF, Pasternack BS, Beebe GW. 1965. Cataract incidence in radar workers. Arch Environ Health 11:179-182.
12. Cooper D, Hemmings K, Saunders P. 2001. Re: "Cancer incidence near radio and television transmitters in Great Britain. I. Sutton Coldfield transmitter; II. All high power transmitters" [Letter]. Am J Epidemiol 153:202-204.
13. COST281 (European Cooperation in the Field of Scientific and Technical Research.) 2001. Mobile Telecommunication Base Stations - Exposure to Electromagnetic Fields. Report of a Short Term Mission within COST 244bis. Available: http://www.cost281.org/activities/Short_term_mission.pdf [accessed 27 October 2004].
14. Dahme M. 1999. Residential RF exposures. Radiat Prot Dosimetry 83:113-117.
15. Davis RL, Mostofi FK. 1993. Cluster of testicular cancer in police officers exposed to hand-held radar. Am J Ind Med 24:231-233.
16. Demers PA, Thomas DB, Rosenblatt KA, Jimenez LM, McTiernan A, Stalsberg H, et al. 1991. Occupational exposure to electromagnetic fields and breast cancer in men. Am J Epidemiol 134:340-347.
17. Dimbylow PJ, Mann SM. 1999. Characterization of energy deposition in the head from cellular phones. Radiat Prot Dosimetry 83:113-117.
18. Dolk H, Elliott P, Shaddick G, Walls P, Thakrar B. 1997a. Cancer incidence near radio and television transmitters in Great Britain. II. All high power transmitters. Am J Epidemiol 145:10-17.
19. Dolk H, Shaddick G, Walls P, Grundy C, Thakrar B, Kleinschmidt I, et al. 1997b. Cancer incidence near radio and television transmitters in Great Britain. I. Sutton Coldfield transmitter. Am J Epidemiol 145:1-9.
20. Dreyer NA, Loughlin JE, Rothman KJ. 1999. Cause-specific mortality in cellular telephone users. JAMA 282:1814-1816.
21. Funch DP, Rothman KJ, Loughlin JE, Dreyer NA. 1996. Utility of telephone company records for epidemiologic studies of cellular telephones. Epidemiology 7:299-302.
22. Garland FC, Shaw E, Gorham ED, Garland CF, White MR, Sinsheimer PJ. 1990. Incidence of leukemia in occupations with potential electromagnetic field exposure in United States Navy personnel. Am J Epidemiol 132:293-303.
23. Ghandi OP, Lazzi G, Tinniswood A, Yu QS. 1999. Comparison of numerical and experimental methods for determination of SAR and radiation patterns of handheld wireless telephones. Bioelectromagnetics 20:93-101.
24. Goldsmith JR. 1995. Epidemiologic evidence of radiofrequency radiation (microwave) effects on health in military, broadcasting, and occupational studies. Int J Occup Environ Health 1:47-57.
25. Goldstein LS, Kheifets L, van Deventer E, Repacholi M. 2003. Comments on "Long-term exposure of Emicro-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence" by Utteridge et al., Radiat. Res. 158, 357-364 (2002). Radiat Res 159:275-276.
26. Grajewski B, Cox C, Schrader SM, Murray WE, Edwards RM, Turner TW, et al. 2000. Semen quality and hormone levels among radiofrequency heater operators. J Occup Environ Med 42:993-1005.
27. Grayson JK. 1996. Radiation exposure, socioeconomic status, and brain tumor risk in the US Air Force: a nested case-control study. Am J Epidemiol 143:480-486.
28. Groves FD, Page WF, Gridley G, Lisimaque L, Stewart PA, Tarone RE, et al. 2002. Cancer in Korean war navy technicians: mortality survey after 40 years. Am J Epidemiol 155:810-818.
29. Hamburger S, Logue JN, Silverman PM. 1983. Occupational exposure to non-ionizing radiation and an association with heart disease: an exploratory study. J Chronic Dis 36:791-802.
30. Hardell L, Mild KH, Carlberg M. 2002. Case-control study on the use of cellular and cordless phones and the risk for malignant brain tumours. Int J Radiat Biol 78:931-936.
31. Hardell L, Mild KH, Carlberg M. 2003. Further aspects on cellular and cordless telephones and brain tumours. Int J Oncol 22:399-407.
32. Hardell L, Mild KH, Pahlson A, Hallquist A. 2001. Ionizing radiation, cellular telephones and the risk for brain tumours. Eur J Cancer Prev 10:523-529.
33. Hardell L, Nasman A, Pahlson A, Hallquist A. 2000. Case-control study on radiology work, medical X-ray investigations, and use of cellular telephones as risk factors for brain tumors. MedGenMed 2:E2.
34. Hardell L, Nasman A, Pahlson A, Hallquist A, Hansson Mild K. 1999. Use of cellular telephones and the risk for brain tumours: a case-control study. Int J Oncol 15:113-116.
35. Hayes RB, Brown LM, Pottern LM, Gomez M, Kardaun JW, Hoover RN, et al. 1990. Occupation and risk for testicular cancer: a case-control study. Int J Epidemiol 19:825-831.
36. Hietanen M, Hämäläinen AM, Husman T. 2002. Hypersensitivity symptoms associated with exposure to cellular telephones: no causal link. Bioelectromagnetics 23:264-270.
37. Hitchcock RT, Patterson RM. 1995. Radio-Frequency and ELF Electromagnetic Energies. A Handbook for Health Professionals. New York:Van Nostrand Reinhold.
38. Hjollund NH, Bonde JP, Skotte J. 1997. Semen analysis of personnel operating military radar equipment [Letter]. Reprod Toxicol 11:897.
39. Hocking B, Gordon IR, Grain HL, Hatfield GE. 1996. Cancer incidence and mortality and proximity to TV towers. Med J Aust 165:601-605.
40. Hollows FC, Douglas JB. 1984. Microwave cataract in radiolinemen and controls. Lancet 2:406-407.
41. Holly EA, Aston DA, Ahn DK, Smith AH. 1996. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology 7:55-61.
42. IEGMP. 2000. Mobile Phones and Health. Chilton, Didcot, UK:Independent Expert Group on Mobile Phones. Available: http://www.iegmp.org.uk/report/text.htm [accessed 5 November 2004].
43. Imaida K, Kuzutani K, Wang J, Fujiwara O, Ogiso T, Kato K, et al. 2001. Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields. Carcinogenesis 22:1837-1841.
44. Inskip PD, Linet MS, Heineman EF. 1995. Etiology of brain tumors in adults. Epidemiol Rev 17:382-414.
45. Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Shapiro WR, Selker RG, et al. 2001. Cellular-telephone use and brain tumors. N Engl J Med 344:79-86.
46. Jauchem JR. 1997. Exposure to extremely-low-frequency electromagnetic fields and radiofrequency radiation: cardiovascular effects in humans. Int Arch Occup Environ Health 70:9-21.
47. Johansen C, Boice JD Jr, McLaughlin JK, Christensen HC, Olsen JH. 2002a. Mobile phones and malignant melanoma of the eye. Br J Cancer 86:348-349.
48. Johansen C, Boice JD Jr, McLaughlin JK, Olsen JH. 2002b. Cellular telephones and cancer - a nationwide cohort studyin Denmark. J Natl Cancer Inst 93:203-207.
49. Koivisto M, Haarala C, Krause CM, Revonsuo A, Laine M, Hämäläinen H. 2001. GSM phone signal does not produce subjective symptoms. Bioelectromagnetics 22:212-215.
50. Krewski D, Byus CV, Glickman BW, Lotz WG, Mandeville R, McBride ML, et al. 2001. Potential health risks of radiofrequency fields from wireless telecommunication devices. J Toxicol Environ Health B Crit Rev 4:1-143.
51. Lagorio S, Rossi S, Vecchia P, De Santis M, Bastianini L, Fusilli M, et al. 1997. Mortality of plastic-ware workers exposed to radiofrequencies. Bioelectromagnetics 18:418-421.
52. Lancranjan I, Maicanescu M, Rafaila E, Klepsch I, Popescu HI. 1975. Gonadic function in workmen with long-term exposure to microwaves. Health Phys 29:381-383.
53. Larsen AI. 1991. Congenital malformations and exposure to high-frequency electromagnetic radiation among Danish physiotherapists. Scand J Work Environ Health 17:318-323.
54. Larsen AI, Olsen J, Svane O. 1991. Gender-specific reproductive outcome and exposure to high-frequency electromagnetic radiation among physiotherapists. Scand J Work Environ Health 17:324-329.
55. Larsen AI, Skotte J. 1991. Can exposure to electromagnetic radiation in diathermy operators be estimated from interview data? A pilot study. Am J Ind Med 19:51-57.
56. Lin RS, Dischinger PC, Conde J, Farrell KP. Occupational exposure to electromagnetic fields and the occurrence of brain tumors. An analysis of possible associations. J Occup Med 27(6):413-419.
57. Logue JN, Hamburger S, Silverman PM, Chiacchierini RP. Congenital anomalies and paternal occupational exposure to shortwave, microwave, infrared, and acoustic radiation. J Occup Med 27(6):451-452.
58. Mantiply ED, Pohl KR, Poppell SW, Murphy JA. 1997. Summary of measured radiofrequency electric and magnetic fields (10 kHz to 30 GHz) in the general and work environment. Bioelectromagnetics 18:563-577.
59. Maskarinec G, Cooper J, Swygert L. 1994. Investigation of increased incidence in childhood leukemia near radio towers in Hawaii: preliminary observations. J Environ Pathol Toxicol Oncol 13:33-37.
60. Mason PA, Walters TJ, DiGiovanni J, Beason CW, Jauchem JR, Dick EJ Jr, et al. 2001. Lack of effect of 94 GHz radio frequency radiation exposure in an animal model of skin carcinogenesis. Carcinogenesis 22:1701-1708.
61. McKenzie DR, Yin Y, Morrell S. 1998. Childhood incidence of acute lymphoblastic leukaemia and exposure to broadcast radiation in Sydney - a second look. Aust NZ J Public Health 22:360-367.
62. Michelozzi P, Capon A, Kirchmayer U, Forastiere F, Biggeri A, Barca A, et al. 2002. Adult and childhood leukemia near a high-power radio station in Rome, Italy. Am J Epidemiol 155:1096-1103.
63. Milham S Jr. 1985. Silent keys: leukaemia mortality in amateur radio operators [Letter). Lancet 1:812.
64. Milham S Jr. 1988. Increased mortality in amateur radio operators due to lymphatic and hematopoietic malignancies. Am J Epidemiol 127:50-54.
65. Morgan RW, Kelsh MA, Zhao K, Exuzides KA, Heringer S, Negrete W. 2000. Radiofrequency exposure and mortality from cancer of the brain and lymphatic/hematopoietic systems. Epidemiology 11:118-127.
66. Moulder JE, Erdreich LS, Malyapa RS, Merritt J, Pickard WF, Vijayalaxmi. 1999. Cell phones and cancer: what is the evidence for a connection? Radiat Res 151:513-531.
67. Muhm JM. 1992. Mortality investigation of workers in an electromagnetic pulse test program. J Occup Med 34:287-292.
68. Muscat JE, Malkin MG, Shore RE, Thompson S, Neugut AI, Stellman SD, et al. 2002. Handheld cellular telephones and risk of acoustic neuroma. Neurology 58:1304-1306.
69. Muscat JE, Malkin MG, Thompson S, Shore RE, Stellman SD, McRee D, et al. 2000. Handheld cellular telephone use and risk of brain cancer. JAMA 284:3001-3007.
70. Navarro EA, Segura J, Portolés M, Gómez-Perretta de Mateo C. 2003. The microwave syndrome: a preliminary study in Spain. Electromagn Biol Med 22:161-169.
71. NRPB. 2003. Health Effects from Radiofrequency Electromagnetic Fields. Report of an Independent Advisory Group on Non-ionising Radiation. Chilton, Didcot, UK:National Radiation Protection Board. Available: http://www.nrpb.org/publications/documents_of_nrpb/pdfs/doc_14_2.pdf [accessed 28 October 2004].
72. Oftedal G, Wilen J, Sandstrom M, Mild KH. 2000. Symptoms experienced in connection with mobile phone use. Occup Med (Lond) 50:237-245.
73. Ouellet-Hellstrom R, Stewart WF. 1993. Miscarriages among female physical therapists who report using radio- and microwave-frequency electromagnetic radiation. Am J Epidemiol 138:775-786.
74. Pearce N, Reif J, Fraser J. Case-control studies of cancer in New Zealand electrical workers. Int J Epidemiol 18(1):55-59.
75. Petridou E, Trichopoulos D. 2002. Leukemias. In: Textbook of Cancer Epidemiology (Adami A, Trichopoulos D, Hunter D, eds). Oxford, UK:Oxford University Press, 556-572.
76. Repacholi MH, Basten A, Gebski V, Noonan D, Finnie J, Harris AW. 1997. Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields. Radiat Res 147:631-640.
77. Robinette CD, Silverman C, Jablon S. 1980. Effects upon health of occupational exposure to microwave radiation (radar). Am J Epidemiol 112:39-53.
78. Rothman KJ, Loughlin JE, Funch DP, Dreyer NA. 1996. Overall mortality of cellular telephone customers. Epidemiology 7:303-305.
79. Royal Society of Canada. 1999. A Review of the Potential Health Risks of Radiofrequency Fields from Wireless Telecommunication Devices. Ottawa, Ontario:Royal Society of Canada. Available: http://www.rsc.ca/english/RFreport.pdf [accessed 4 November 2004].
80. Sandstrom M, Wilen J, Oftedal G, Hansson Mild K. 2001. Mobile phone use and subjective symptoms. Comparison of symptoms experienced by users of analogue and digital mobile phones. Occup Med (Lond) 51:25-35.
81. Santini R, Santini P, Danze JM, Le Ruz P, Seigne M. 2002. Investigation on the health of people living near mobile telephone relay stations: I/ Incidence according to distance and sex. Pathol Biol (Paris) 50:369-373.
82. Santini R, Santini P, Danze JM, Le Ruz P, Seigne M. 2003. Symptoms experienced by people in vicinity of base stations: II/ Incidences of age, duration of exposure, location of subjects in relation to the antennas and other electromagnetic factors. Pathol Biol (Paris) 51:412-415.
83. Savitz DA, Dufort V, Armstrong B, Theriault G. 1997. Lung cancer in relation to employment in the electrical utility industry and exposure to magnetic fields. Occup Environ Med 54:396-402.
84. Schrader SM, Langford RE, Turner TW, Breitenstein MJ, Clark JC, Jenkins BL, et al. 1998. Reproductive function in relation to duty assignments among military personnel. Reprod Toxicol 12:465-468.
85. Schüz J, Mann S. 2000. A discussion of potential exposure metrics for use in epidemiological studies on human exposure to radiowaves from mobile phone base stations. J Expo Anal Environ Epidemiol 10:600-605.
86. Selvin S, Schulman J, Merrill DW. 1992. Distance and risk measures for the analysis of spatial data: a study of childhood cancers. Soc Sci Med 34:769-777.
87. Shacklett DE, Tredici TJ, Epstein DL. 1975. Evaluation of possible microwave-induced lens changes in the United States Air Force. Aviat Space Environ Med 46:1403-1406.
88. Silvi AM, Zari A, Licitra G. 2001. Assessment of the temporal trend of the exposure of people to electromagnetic fields produced by base stations for mobile telephones. Radiat Prot Dosimetry 97:387-390.
89. Stang A, Anastassiou G, Ahrens W, Bromen K, Bornfeld N, Jockel KH. 2001. The possible role of radiofrequency radiation in the development of uveal melanoma. Epidemiology 12:7-12.
90. Swerdlow AJ. 1999. Measurement of radiofrequency radiation exposure in epidemiological studies. Radiat Prot Dosimetry 83:149-153.
91. Szmigielski S. 1996. Cancer morbidity in subjects occupationally exposed to high frequency (radiofrequency and microwave) electromagnetic radiation. Sci Total Environ 180:9-17.
92. Szmigielski S, Sobiczewska E, Kubacki R. 2001. Carcinogenic potency of microwave radiation: overview of the problem and results of epidemiological studies on Polish military personnel. Eur J Oncol 6:193-199.
93. Taskinen H, Kyyronen P, Hemminki K. 1990. Effects of ultrasound, shortwaves, and physical exertion on pregnancy outcome in physiotherapists. J Epidemiol Community Health 44:196-201.
94. Thomas TL, Stolley PD, Stemhagen A, Fontham ET, Bleecker ML, Stewart PA, et al. 1987. Brain tumor mortality risk among men with electrical and electronics jobs: a case-control study. J Natl Cancer Inst 79:233-238.
95. Tynes T, Hannevik M, Andersen A, Vistnes AI, Haldorsen T. 1996. Incidence of breast cancer in Norwegian female radio and telegraph operators. Cancer Causes Control 7:197-204.
96. Utteridge TD, Gebski V, Finnie JW, Vernon-Roberts B, Kuchel TR. 2002. Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence. Radiat Res 158:357-364.
97. Weyandt TB, Schrader SM, Turner TW, Simon SD. 1996. Semen analysis of military personnel associated with military duty assignments. Reprod Toxicol 10:521-528.
98. Wright WE, Peters JM, Mack TM. Leukaemia in workers exposed to electrical and magnetic fields. Lancet 2:1160-1161.