Immune responses to GP82 provide protection against mucosal Trypanosoma cruzi infection

Memorias do Instituto Oswaldo Cruz

Volumn 105, Issue 5, 2010, Pages 687-691

  Eickhoff, Christopher S ^a   Giddings, Olivia K ^a   Yoshida, Nobuko ^b   Hoft, Daniel F ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Mucosal immunity; Trypanosoma cruzi; Vaccines

Indexed keywords

MUS; TRYPANOSOMA CRUZI;

EID: 77957231220     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762010000500015     Document Type: Article

References (30)

1. Alarcón de Noya B, Díaz-Bello Z, Colmenares C, Ruiz-Guevara R, Mauriello L, Zavala-Jaspe R, Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela. J Infect Dis 201: 1308-1315.
2. Araújo AF, de Alencar BC, Vasconcelos JR, Hiyane MI, Marinho CR, Penido ML, Boscardin SB, Hoft DF, Gazzinelli RT, Rodrigues MM 2005. CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infect Immun 73: 6017-6025.
3. Atwood JA 3rd, Weatherly DB, Minning TA, Bundy B, Cavola C, Opperdoes FR, Orlando R, Tarleton RL 2005. The Trypanosoma cruzi proteome. Science 309: 473-476.
4. Basombrio MA, Segura MA, Mora MC, Gomez L 1993. Field trial of vaccination against American trypanosomiasis (Chagas' disease) in dogs. Am J Trop Med Hyg 49: 143-151.
5. Beltrão H de B, Cerroni M de P, Freitas DR, Pinto AY, Valente V da C, Valente SA, Costa E de G, Sobel J 2009. Investigation of two outbreaks of suspected oral transmission of acute Chagas disease in the Amazon region, Para state, Brazil, in 2007. Trop Doct 39: 231-232.
6. CDC - Centers for Disease Control and Prevention 2007. Blood donor screening for Chagas disease - United States, 2006-2007. MMWR Morb Mortal Wkly Rep 56: 141-143.
7. Cohen JE, Gürtler RE 2001. Modeling household transmission of American trypanosomiasis. Science 293: 694-698.
8. Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW 2005. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS 19: 1473-1479.
9. Cortez M, Neira I, Ferreira D, Luquetti AO, Rassi A, Atayde VD, Yoshida N 2003. Infection by Trypanosoma cruzi metacyclic forms deficient in gp82 but expressing a related surface molecule, gp30. Infect Immun 71: 6184-6191.
10. Dias JP, Bastos C, Araújo E, Mascarenhas AV, Martins Netto E, Grassi F, Silva M, Tatto E, Mendonça J, Araújo RF, Shikanai-Yasuda MA, Aras R 2008. Acute Chagas disease outbreak associated with oral transmission. Rev Soc Bras Med Trop 41: 296-300.
11. Dumais N, Patrick A, Moss RB, Davis HL, Rosenthal KL 2002. Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J Infect Dis 186: 1098-1105.
12. Frank FM, Petray PB, Cazorla SI, Muñoz MC, Corral RS, Malchiodi EL 2003. Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes. Vaccine 22: 77-86.
13. Fujimura AE, Kinoshita SS, Pereira-Chioccola VL, Rodrigues MM 2001. DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene. Infect Immun 69: 5477-5486.
14. Giddings OK, Eickhoff CS, Smith TJ, Bryant LA, Hoft DF 2006. Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection. Infect Immun 74: 5549-5560.
15. Hoft DF 1996. Differential mucosal infectivity of different life stages of Trypanosoma cruzi. Am J Trop Med Hyg 55: 360-364.
16. Hoft DF, Eickhoff CS 2002. Type 1 immunity provides optimal protection against both mucosal and systemic Trypanosoma cruzi challenges. Infect Immun 70: 6715-6725.
17. Hoft DF, Eickhoff CS 2005. Type 1 immunity provides both optimal mucosal and systemic protection against a mucosally invasive, intracellular pathogen. Infect Immun 73: 4934-4940.
18. Hoft DF, Eickhoff CS, Giddings OK, Vasconcelos JR, Rodrigues MM 2007. Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic Trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming. J Immunol 179: 6889-6900.
19. Hoft DF, Schnapp AR, Eickhoff CS, Roodman ST 2000. Involvement of CD4+ Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi. Infect Immun 68: 197-204.
20. Krieg AM 2000. Immune effects and mechanisms of action of CpG motifs. Vaccine 19: 618-622.
21. Manque PM, Neira I, Atayde VD, Cordero E, Ferreira AT, da Silveira JF, Ramirez M, Yoshida N 2003. Cell adhesion and Ca2+ signaling activity in stably transfected Trypanosoma cruzi epimastigotes expressing the metacyclic stage-specific surface molecule gp82. Infect Immun 71: 1561-1565.
22. Neira I, Silva FA, Cortez M, Yoshida N 2003. Involvement of Trypanosoma cruzi metacyclic trypomastigote surface molecule gp82 in adhesion to gastric mucin and invasion of epithelial cells. Infect Immun 71: 557-561.
23. Nóbrega AA, Garcia MH, Tatto E, Obara MT, Costa E, Sobel J, Araujo WN 2009. Oral transmission of Chagas disease by consumption of açaí palm fruit, Brazil. Emerg Infect Dis 15: 653-655.
24. Pereira KS, Schmidt FL, Guaraldo AM, Franco RM, Dias VL, Passos LA 2009. Chagas' disease as a foodborne illness. J Food Prot 72: 441-446.
25. Rodrigues MM, de Alencar BC, Claser C, Tzelepis F, Silveira EL, Haolla FA, Dominguez MR, Vasconcelos JR 2009. Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice. Mem Inst Oswaldo Cruz 104 (Suppl. 1): 281-287.
26. Santori FR, Paranhos-Bacalla GS, Franco DA Silveira J, Yamauchi LM, Araya JE, Yoshida N 1996. A recombinant protein based on the Trypanosoma cruzi metacyclic trypomastigote 82-kilodalton antigen that induces and effective immune response to acute infection. Infect Immun 64: 1093-1099.
27. Teixeira MM, Yoshida N 1986. Stage-specific surface antigens of metacyclic trypomastigotes of Trypanosoma cruzi identified by monoclonal antibodies. Mol Biochem Parasitol 18: 271-282.
28. The T. cruzi proteome database [database on the internet]. The T. cruzi proteome. Athens (GA): c 2007 - [cited January 2010]. Available from: kiwi.rcr.uga.edu/tcprot/.
29. Yoshida N 2006. Molecular basis of mammalian cell invasion by Trypanosoma cruzi. An Acad Bras Cienc 78: 87-111.
30. Yoshida N 2009. Molecular mechanisms of Trypanosoma cruzi infection by oral route. Mem Inst Oswaldo Cruz 104 (Suppl. 1): 101-107.