Phosphorylation of eEF1A1 at Ser300 by TβR-I results in inhibition of mRNA translation

Current Biology

Volumn 20, Issue 18, 2010, Pages 1615-1625

  Lin, Kah Wai ^a   Yakymovych, Ihor ^a,b   Jia, Min ^a   Yakymovych, Mariya ^b   Souchelnytskyi, Serhiy ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EEF1A1 PROTEIN, HUMAN; ELONGATION FACTOR 1; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; SERINE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BREAST TUMOR; CELL LINE; CELL PROLIFERATION; FEMALE; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE; CELL PROLIFERATION; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE ELONGATION FACTOR 1; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SERINE;

EUKARYOTA;

EID: 77957230094     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.08.017     Document Type: Article

References (37)

1. K. Miyazono, H. Suzuki, and T. Imamura Regulation of TGF-β signaling and its roles in progression of tumors Cancer Sci. 94 2003 230 234
2. X.-H. Feng, and R. Derynck Specificity and versatility in tgf-β signaling through Smads Annu. Rev. Cell Dev. Biol. 21 2005 659 693
3. J. Massagué TGFbeta in Cancer Cell 134 2008 215 230
4. M.K. Lee, C. Pardoux, M.C. Hall, P.S. Lee, D. Warburton, J. Qing, S.M. Smith, and R. Derynck TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA EMBO J. 26 2007 3957 3967
5. B.N. Ray, N.Y. Lee, T. How, and G.C. Blobe ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration Carcinogenesis 31 2010 435 441
6. J.A. Ubersax, E.L. Woodbury, P.N. Quang, M. Paraz, J.D. Blethrow, K. Shah, K.M. Shokat, and D.O. Morgan Targets of the cyclin-dependent kinase Cdk1 Nature 425 2003 859 864
7. F. Meggio, and L.A. Pinna One-thousand-and-one substrates of protein kinase CK2? FASEB J. 17 2003 349 368
8. S.A. Johnson, and T. Hunter Kinomics: Methods for deciphering the kinome Nat. Methods 2 2005 17 25
9. M.J. Clemens, and U.-A. Bommer Translational control: The cancer connection Int. J. Biochem. Cell Biol. 31 1999 1 23
10. R.H. Chen, P.J. Miettinen, E.M. Maruoka, L. Choy, and R. Derynck A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor Nature 377 1995 548 552
11. L. Choy, and R. Derynck The type II transforming growth factor (TGF)-β receptor-interacting protein TRIP-1 acts as a modulator of the TGF-β response J. Biol. Chem. 273 1998 31455 31462
12. S. McGonigle, M.J. Beall, and E.J. Pearce Eukaryotic initiation factor 2α subunit associates with TGFβ receptors and 14-3-3epsilon and acts as a modulator of the TGFβ response Biochemistry 41 2002 579 587
13. S. Lamouille, and R. Derynck Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway J. Cell Biol. 178 2007 437 451
14. C. Petritsch, H. Beug, A. Balmain, and M. Oft TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest Genes Dev. 14 2000 3093 3101
15. A. Lamberti, M. Caraglia, O. Longo, M. Marra, A. Abbruzzese, and P. Arcari The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: Review article Amino Acids 26 2004 443 448
16. I. Yakymovych, P. Ten Dijke, C.H. Heldin, and S. Souchelnytskyi Regulation of Smad signaling by protein kinase C FASEB J. 15 2001 553 555
17. I. Yakymovych, U. Engström, S. Grimsby, C.H. Heldin, and S. Souchelnytskyi Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase Biochemistry 41 2002 11000 11007
18. G.J. Browne, and C.G. Proud Regulation of peptide-chain elongation in mammalian cells Eur. J. Biochem. 269 2002 5360 5368
19. B.S. Negrutski, and A.V. El'skaia Functional compartmentation of the translation apparatus and channeling of tRNA/aminoacyl-tRNA in cells of higher eukaryotes Mol. Biol. (Mosk.) 35 2001 702 707
20. G.R. Andersen, P. Nissen, and J. Nyborg Elongation factors in protein biosynthesis Trends Biochem. Sci. 28 2003 434 441
21. Phe, EF-Tu, and a GTP analog Science 270 1995 1464 1472
22. P. Nissen, S. Thirup, M. Kjeldgaard, and J. Nyborg The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA Structure 7 1999 143 156
23. M. Al-Maghrebi, J.T. Anim, and A.A. Olalu Up-regulation of eukaryotic elongation factor-1 subunits in breast carcinoma Anticancer Res. 25 3c 2005 2573 2577
24. P. Joseph, Y.X. Lei, W.Z. Whong, and T.M. Ong Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene J. Biol. Chem. 277 2002 6131 6136
25. B. Ender, P. Lynch, Y.H. Kim, N.V. Inamdar, K.R. Cleary, and M.L. Frazier Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas Mol. Carcinog. 7 1993 18 20
26. R.A. Clark, G.A. McCoy, J.M. Folkvord, and J.M. McPherson TGF-beta 1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event J. Cell. Physiol. 170 1997 69 80
27. L. Chen, and K. Madura Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue Cancer Res. 65 2005 5599 5606
28. C. Cans, B.J. Passer, V. Shalak, V. Nancy-Portebois, V. Crible, N. Amzallag, D. Allanic, R. Tufino, M. Argentini, and D. Moras Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A Proc. Natl. Acad. Sci. USA 100 2003 13892 13897
29. N. Anand, S. Murthy, G. Amann, M. Wernick, L.A. Porter, I.H. Cukier, C. Collins, J.W. Gray, J. Diebold, D.J. Demetrick, and J.M. Lee Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer Nat. Genet. 31 2002 301 305
30. M. Tatsuka, H. Mitsui, M. Wada, A. Nagata, H. Nojima, and H. Okayama Elongation factor-1 alpha gene determines susceptibility to transformation Nature 359 1992 333 336
31. S. Taniguchi, S. Miyamoto, H. Sadano, and H. Kobayashi Rat elongation factor 1 alpha: Sequence of cDNA from a highly metastatic fos-transferred cell line Nucleic Acids Res. 19 1991 6949
32. B.T. Edmonds, J. Wyckoff, Y.G. Yeung, Y. Wang, E.R. Stanley, J. Jones, J. Segall, and J. Condeelis Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma J. Cell Sci. 109 1996 2705 2714
33. R.V. Gopalkrishnan, Z.-Z. Su, N.I. Goldstein, and P.B. Fisher Translational infidelity and human cancer: Role of the PTI-1 oncogene Int. J. Biochem. Cell Biol. 31 1999 151 162
34. R. Shen, Z.Z. Su, C.A. Olsson, and P.B. Fisher Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display Proc. Natl. Acad. Sci. USA 92 1995 6778 6782
35. G. Liu, W.M. Grant, D. Persky, V.M. Latham Jr., R.H. Singer, and J. Condeelis Interactions of elongation factor 1alpha with F-actin and β-actin mRNA: Implications for anchoring mRNA in cell protrusions Mol. Biol. Cell 13 2002 579 592
36. V.P. Krymskaya, R. Hoffman, A. Eszterhas, V. Ciocca, and R.A. Panettieri Jr. TGF-β 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells Am. J. Physiol. 273 1997 L1220 L1227
37. R. Fukunaga, and T. Hunter MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates EMBO J. 16 1997 1921 1933