TGF-β1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event

Journal of Cellular Physiology

Volumn 170, Issue 1, 1997, Pages 69-80

  Clark, Richard A F ^a   McCoy, Georgia A ^b   Folkvord, Joy M ^b   McPherson, John M ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c Cenzyme Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPIONITRILE; FIBRONECTIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; DNA SYNTHESIS; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; GRANULATION TISSUE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WOUND HEALING;

AMINOPROPIONITRILE; ANTIBODIES, BLOCKING; BLOOD PROTEINS; CELL DIVISION; CELLS, CULTURED; CROSS-LINKING REAGENTS; CULTURE MEDIA; DNA; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; HUMANS; MALE; SKIN; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0031013741     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199701)170:1<69::AID-JCP8>3.0.CO;2-J     Document Type: Article

References (55)

1. Abergel, K.P., Pizzurro, D., Meeker, C.A., Lask, G., Matsuoka, L.Y., Minor, R.R., Chiu, M.-L., and Uitto, J. (1984) Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol., 84:384-390.
2. Assoian, R.K., and Sporn, M.B. (1987) Type beta transforming growth factor in human platelets: Release during platelet degranulation and action on vascular smooth muscle cells. J. Cell Biol., 102:1217-1223.
3. Booth, B.A., Polak, K.L., and Uitto, J. (1980) Collagen biosynthesis by human skin fibroblasts. I. Optimization of the culture conditions for synthesis of type I and type III procollagens. Biochim. Biophys. Acta, 607:145-160.
4. Border, W.A., and Noble, N.A. (1994) Transforming growth factor β in tissue fibrosis. N. Engl. J. Med., 331:1286-1292.
5. Brown, P.D., Wakefield, L.M., Levinson, A.D., and Sporn, M.B. (1990) Physiochemical activation of recombinant latent transforming growth factor-betas 1, 2, and 3. Growth Factors, 3:35-43.
6. Chen, L.B., Murray, A., Segal, R.A., Bushnell, A., and Walsh, M.L. (1978) Studies on intracellular LETS glycoprotein matrices. Cell, 14:377-391.
7. Clark, R.A.F. (1993) Regulation of fibroplasia in cutaneous wound repair. Am. J. Med. Sci., 306:42-48.
8. Clark, R.A.F. (1996) Wound repair: Overview and general considerations. In: Molecular and Cellular Biology of Wound Repair. R.A.F. Clark, ed. Plenum, New York, 2nd ed., pp. 3-50.
9. Clark, R.A.F., Dvorak, H.F., and Colvin, R.B. (1981) Fibronectin in delayed-type hypersensitivity skin reactions. Associations with vessel permeability and endothelial cell activation. J. Immunol., 126:787-793.
10. Clark, R.A.F., Folkvord, J.M., and Nielsen, L.D. (1986) Either exogenous or endogenous fibronectin can promote adherence of human endothelial cells. J. Cell Sci., 82:263-280.
11. Clark, R.A.F., Nielsen, L.D., Howell, S.E., and Folkvork, J.M. (1985) Nonstratifying cultured keratinocytes synthesize both laminin and fibronectin but deposit only fibronectin in the pericellular matrix. J. Cell. Biochem., 28:127-141.
12. Clark, R.A.F., Nielsen, L.D., Welch, M.P., and McPherson, J.M. (1995) Collagen matrices attenuate the collagen synthetic response of cultured fibroblasts to TGF-β. J. Cell Sci., 108:1251-1261.
13. Dulbecco, R. (1970) Topoinhibition and serum requirement of transformed and untransformed cells. Nature, 227:802-807.
14. Engvall, E., and Ruoslahti, E. (1977) Binding of soluble form of fibroblasts surface protein, fibronectin, to collagen. Int. J. Cancer, 20:1-12.
15. Fukamizu, H., and Grinnell, F. (1990) Spatial organization of extracellular matrix and fibroblast activity: Effects of serum, transforming growth factor β, and fibronectin. Exp. Cell Res., 190:276-282.
16. Furie, M.B., and Rifkin, D.B. (1980) Proteolytically derived fragments of human plasma fibronectin and their localization within intact molecule. J. Biol. Chem., 365:3134-3140.
17. Grimwood, R.E., Baskin, J.B., Nielsen, L.D., Ferris, C.F., and Clark, R.A.F. (1988) Fibronectin extracellular matrix assembly by human epidermal cells implanted into athymic mice. J. Invest. Dermatol., 90:434-440.
18. Grinnell, F., Fukamizu, H., Pawelek, P., and Nakagawa, S. (1989) Collagen processing, crosslinking, and fibril bundle assembly in matrix produced by fibroblasts in long-term cultures supplemented with ascorbic acid. Exp. Cell Res., 181:483-491.
19. Guadagno, T.M., Ohtsubo, M., Roberts, J.M., and Assoian, R.K. (1993) A link between cyclin A expression and adhesion-dependent cell cycle progression. Science, 262:1572-1575.
20. Harpel, J.G., Metz, C.N., Kojima, S., and Rifkin, D.B. (1992) Control of transforming growth factor-beta activity: Latency vs. activation. Prog. Growth Factor Res., 4:321-335.
21. Heimark, R.L., Twardzik, D.R., and Schwartz, S. (1986) Inhibition of endothelial cell regeneration by type-beta transforming growth factor from platelets. Science, 233:1078-1080.
22. Henson, P.M. (1971) The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis and adherence to nonphagocytosable surfaces. J. Immunol., 107:1547-1557.
23. Hynes, R.O., and Destree, A.T. (1978) Relationships between fibronectin (LETS) protein and actin. Cell, 15:875-886.
24. Ignotz, R.A., and Massague, J. (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into extracellular matrix. J. Biol. Chem., 261:4337-4340.
25. Katz, M.H., Alvarez, A.F., Kirsner, R.S., Eaglstein, W.H., and Falanga, V. (1991) Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J. Am. Acad. Dermatol., 25:1054-1058.
26. Kerhl, J.H., Roberts, A.B., Wakefield, L.M., Jakowlew, S., Sporn, M.B., and Fauci, A.S. (1986a) Transforming growth factor β is an important immunomodulatory protein for human B lymphocytes. J. Immunol., 137:3855-3860.
27. Kerhl, J.H., Wakefield, L.M., Roberts, A.B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M.B., and Fauci, A.S. (1986b) Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med., 163:1037-1050.
28. Keski-Oja, T., Todaro, G.J., and Vaheri, A. (1981) Thrombin affects fibronectin and procollagen in the pericellular matrix of cultured human fibroblasts. Biochem. Biophys. Acta, 673:323-331.
29. Kulkarni, A.B., Huh, C.G., Becker, D., Geiser, A., Lyght, M., Flanders, K.C., Roberts, A.B., Sporn, M.B., Ward, J.M., and Karlsonn, S. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U. S. A., 90:770-774.
30. Labarca, C., and Paigen, K. (1980) A simple, rapid and sensitive DNA assay procedure. Anal. Biochem., 102:344-352.
31. Layman, D.L., McGoodwin, E.B., and Martin, G.R. (1971) The nature of collagen synthesis by cultured human fibroblasts. Proc. Natl. Acad. Sci. U. S. A., 68:454-458.
32. Leof, E.B., Proper, J.A., Goustin, A.S., Shipley, G.D., DiCorleto, P.E., and Moses, H.L. (1986) Induction of c-sis RNA and activity similar to platelet-derived growth factor by transforming growth factor-β: A proposed model for indirect autogenesis involving autocrine activity. Proc. Natl. Acad. Sci. U. S. A., 83:2453-2457.
33. Lieberman, M.A., and Glaser, L. (1981) Density-dependent regulation of cell growth: An example of a cell-cell recognition phenomenon. J. Membr. Biol., 63:1-11.
34. Lyons, R.M., Keski-Oja, J., and Moses, H.L. (1988) Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J. Cell Biol., 106:1659-1665.
35. Madri, J.A., Pratt, B.M., and Tucker, A.M. (1988) Phenotypic modulation of endothelial cells by transforming growth factor-β depends upon the composition and organization of the extracellular matrix. J. Cell Biol., 156:1375-1385.
36. 1 antibodies to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J. Cell Biol., 92:485-492.
37. Merwin, J.R., Newman, W., Beall, D., Tucker, A., and Madri, J.A. (1991) Vascular cells respond differentially to transforming growth factors-β1 and β2. Am. J. Pathol., 138:37-51.
38. Miyazono, K., Ichijo, H., and Heldin, C.H. (1993) Transforming growth factor-beta: Latent forms, binding proteins and receptors. Growth Factors, 8:11-22.
39. Nathan, R.M., Bentz, H., Armstrong, K.M., Piez, K.A., Smestad, T.L., Ellingsworth, L.R., McPherson, J.M., and Seyedin, S.M. (1988) Osteogenesis in rats with an inductive bovine composite. J. Orthop. Res., 6:324-334.
40. Norris, D.A., Clark, R.A.F., Swigart, L.M., Huff, C., Weston, W., and Howell, S. (1982) Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes. J. Immunol., 129:1612-1618.
41. Peters, J.H., Maunder, R.J., Woolf, A.D., Cochrane, C.G., and Ginsberg, M.H. (1989) Elevated plasma levels of ED1+ (cellular) fibronectin in patients with vascular injury. J. Lab. Clin. Med., 113:586-597.
42. Peters, J.H., Sporn, L.A., Ginsberg, M.H., and Wagner, D.D. (1990) Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1). Blood, 75:1801-1808.
43. Reed, M.J., Puolakkainen, P., Lane, T.F., Dickerson, D., Bornstein, P., and Sage, E.H. (1993) Differential expression of SPARC and thrombospondin 1 in wound repair: Immunolocalization and in situ hybridization. J. Histochem. Cytochem., 41:1467-1477.
44. Roberts, A.B., Anzano, M.A., Lamb, L.C., Smith, J.M., and Sporn, M.B. (1985) Type beta transforming growth factor: A bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. U.S.A., 82:119-123.
45. Roberts, A.B., Sporn, M.B., Assoian, R.K., Smith, J.M., Roche, M.S. Heine, U.F., Liotta, L., Falanga, V., Kehrl, J.H., and Fauci, A.S. (1986) Transforming growth factor beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation. Proc. Natl. Acad. Sci. U. S. A., 83:4167-4171.
46. Schultz-Cherry, S., and Murphy-Ullrich, J.E. (1993) Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J. Cell Biol., 122:923-932.
47. Shipley, G.D., Pittelkow, M.R., Wille, J.J., Scott, R.E., and Moses, H.L. (1986) Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Cancer Res., 46:2068-2071.
48. Shull, M.M., Ormsby, I., Kier, A.B., Pawlowski, S., Diebold, R.J., Vin, M., Allen, R., Sidman, C., Proetzel, G., and Calvin, D. (1992) Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature, 359:693-699.
49. Skalli, O., and Gabbiani, G. (1988) The biology of the myofibroblast relationship to wound contraction and fibrocontractive diseases. In: Molecular and Cellular Biology of Wound Repair. R.A.F. Clark and P.M. Henson, eds. Plenum Press, New York, pp. 373-402.
50. Soma, Y., and Grotendorst, G.R. (1989) TGF-β stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides. J. Cell. Physiol., 140:246-253.
51. Sporn, M.B., Roberts, A.B., Shull, J.H., Smith, J.M., Ward, J.M., and Sodek, J. (1983) Polypeptide transforming growth factor isolated from bovine sources and used for wound healing in vitro. Science, 219:1329-1331.
52. Takehara, K., LeRoy, B.C., and Grotendorst, G.R. (1987) TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth regulatory (competence) gene expression. Cell, 49:415-422.
53. Welch, M.P., Odland, G.F., and Clark, R.A.F. (1990) Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J. Cell Biol., 110:133-145.
54. Wittenberger, B., and Glazer, L. (1977) Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. Proc. Natl. Acad. Sci. U. S. A., 74:2251-2255.
55. Yamada, K.M. (1989) Fibronectin domains and receptors. In: Fibronectin. D.F. Mosher, ed. Academic Press, New York, pp. 47-121.