TNF blocker drugs modulate human TNF-α-converting enzyme pro-domain shedding induced by autoantibodies

Immunobiology

Volumn 215, Issue 11, 2010, Pages 874-883

  Sisto, Margherita ^a   Lisi, Sabrina ^a   Lofrumento, Dario D ^b   Caprio, Simone ^a   Mitolo, Vincenzo ^a   D'Amore, Massimo ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

Author keywords

Adalimumab; Autoantibodies; Autoimmune disease; Etanercept; Shedding; TACE

Indexed keywords

ADALIMUMAB; ETANERCEPT; RO ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; SALIVARY GLAND; SJOEGREN SYNDROME;

ADAM PROTEINS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; IMMUNOGLOBULIN G; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TUMOR NECROSIS FACTOR; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC; SALIVARY GLANDS; SJOGREN'S SYNDROME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77957226574     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2009.11.005     Document Type: Article

References (33)

1. Ackermann C., Kavanaugh A. Tumor necrosis factor as a therapeutic target of rheumatologic disease. Expert Opin. Ther. Targets 2007, 1(1):1369-1384.
2. Black R.A., Rauch C.T., Kozlosky C.J., Peschon J.J., Slack J.L., Wolfson M.F., et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 1997, 385:729-733.
3. Brynskov J., Foegh P., Pedersen G., Ellervik C., Kirkegaard T., Bingham A., et al. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 2002, 51:37-43.
4. Bzowska M., Jura N., Lassak A., Black R.A., Bereta J. Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells. Eur. J. Biochem. 2004, 271:2808-2820.
5. Ding T., Li L., Zhu K., Huang W., Yang Y. Relationship between the increase of secretion of sTNF alpha induced by lipopolysaccharides and the enhanced expression of TACE mRNA in HL-60 cells and adhesive cells from human spleen. J. Tongji Med. Univ. 2001, 21:265-279.
6. Doedens J.R., Black R.A. Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme. J. Biol. Chem. 2000, 275:14598-14607.
7. Edwards D.R., Handsley M.M., Pennington C. The ADAM metalloproteinases. Mol. Aspects Med. 2008, 29:258-289.
8. Furst D.E., Schiff M.H., Fleischmann R.M., Strand V., Birbara C.A., Compagnone D., et al. Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J. Rheumatol. 2003, 30:2563-2571.
9. Haga S., Yamamoto N., Nakai-Murakami C., Osawa Y., Tokunaga K., Sata T., et al. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. Proc. Natl. Acad. Sci. USA 2008, 105:7809-7814.
10. Kapsogeorgou E.K., Dimitriou I.D., Abu-Helu R.F., Moutsopoulos H.M., Manoussakis M.N. Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells. Clin. Exp. Immunol. 2001, 124:126-133.
11. Kapsogeorgou E.K., Moutsopoulos H.M., Manoussakis M.N. Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. J. Immunol. 2001, 166:3107-3113.
12. Killar L., White J., Black R., Peschon J. Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE). Ann. N Y Acad. Sci. 1998, 878:442-452.
13. Lisi S., Sisto M., Soleti R., Saponaro C., Scagliusi P., D'Amore M., et al. J. Oral. Patho. Med. Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjögren's syndrome and apoptosis in human salivary gland cell line A-253 2007, 36:511-523.
14. Majka S., McGuire P.G., Das A. Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2002, 43:260-266.
15. Mochizuki S., Shimoda M., Shiomi T., Fujii Y., Okada Y. ADAM 28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. Biochem. Biophys. Res. Commun. 2004, 315:79-84.
16. Morange P.E., Tregouet D.A., Godefroy T., Saut N., Bickel C., Rupprecht H.J., et al. Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the Athero Gene study. J. Mol. Med. 2008, 86:1153-1161.
17. Moss M.L., Jin S.L., Becherer J.D., Bickett D.M., Burkhart W., Chen W.J., et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 1997, 385:733-735.
18. Moss M.L., Sklair-Tavron L., Nudelman R. Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 2008, 4:300-309.
19. Obeid D., Nguyen J., Lesavre P., Bauvois B. Differential regulation of tumor necrosis factor-alpha-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells. Oncogene 2007, 26:102-110.
20. Ohta S., Harigai M., Tanaka M., Kawaguchi Y., Sugiura T., Takagi K., et al. Tumour necrosis factor-{alpha} (TNF-{alpha}) converting enzyme contributes to production of TNF-{alpha} in synovial tissues from patients with rheumatoid arthritis. J. Rheumatol. 2001, 28:1756-1763.
21. Patel I.R., Attur M.G., Patel R.N., Stuchin S.A., Abagyan R.A., Abramson S.B., et al. TNF-{alpha} convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-{alpha}. J. Immunol. 1996, 160:4570-4579.
22. Peiretti F., Canault M., Bernot D., Bonardo B., Deprez-Beauclair P., Juhan-Vague I., et al. Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme. Exp. Cell. Res. 2003, 285:278-285.
23. Ramos-Casals M., Brito-Zerón P., Muñoz S., Soto M.J., BIOGEAS STUDY Group A systematic review of the off-label use of biological therapies in systemic autoimmune diseases. Medicine (Baltimore) 2008, 87:345-364.
24. Schlöndorff J., Becherer J.D., Blobel C.P. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem. J. 2002, 347:131-138.
25. Seifert T., Kieseier B.C., Ropele S., Strasser-Fuchs S., Quehenberger F., Fazekas F., et al. TACE mRNA expression in peripheral mononuclear cells precedes new lesions on MRI in multiple sclerosis. Mult. Scler. 2002, 8:447-451.
26. Sens D.A., Hintz D.S., Rudisill M.T., Sens M.A., Spicer S.S. Explant culture of human submandibular gland epithelial cells: evidence for ductal origin. Lab. Invest. 1985, 52:559-567.
27. Sisto M., D'Amore M., Caprio S., Mitolo V., Scagliusi P., Lisi S. Tumor necrosis factor inhibitors block apoptosis of human epithelial cells of the salivary glands. Ann. N Y Acad. Sci. 2009, 1171:407-414.
28. Sisto M., D'Amore M., Scagliusi P., Mitolo V., Lisi S. Selective TNF-Alpha gene silencing Attenuates Apoptosis in Human Salivary Gland Epithelial Cells. Inter. J. Immunopathol. Pharmacol. 2008, 21:1045-1047.
29. Sisto M., Lisi S., Castellana D., Scagliusi P., D'Amore M., Caprio S., et al. Autoantibodies from Sjögren's syndrome induce activation of both the intrinsic and extrinsic apoptotic pathways in human salivary gland cell line A-253. J. Autoimmun. 2006, 27:38-49.
30. Soond S.M., Everson B., Riches D.W., Murphy G. ERK-mediated phosphorylation of Thr735 in TNF alpha-converting enzyme and its potential role in TACE protein trafficking. J. Cell Sci. 2005, 118:2371-2380.
31. Tachida Y., Nakagawa K., Saito T., Saido T.C., Honda T., Saito Y., et al. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in A beta production. J. Neurochem. 2008, 104:1387-1393.
32. Trifilieff A., Walker C., Keller T., Kottirsch G., Neumann U. Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation. Br. J. Pharmacol. 2002, 135:1655-1664.
33. Vitali C., Bombardieri S., Jonsson R., Moutsopoulos H.M., Alexander E.L., Carsons S.E., et al. European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheum. Dis. 2002, 61:554-558.