2DG enhances the susceptibility of breast cancer cells to doxorubicin

Central European Journal of Biology

Volumn 5, Issue 6, 2010, Pages 739-748

  Ahmad, Iman M ^a   Mustafa, Ebtihal H ^a   Mustafa, Noor H ^a   Tahtamouni, Lubna H ^a   Abdalla, Maher Y ^a,b  

^a HASHEMITE UNIVERSITY   (Jordan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2DG; Breast cancer; BSO; Doxorubicin; GSH; Oxidative stress

Indexed keywords

EID: 77957226436     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-010-0060-y     Document Type: Article

References (47)

1. Weber G. Enzymology of cancer cells (second of two parts), N. Engl. J. Med., 1977, 296, 541-551.
2. Warburg O. On the Origin of Cancer Cells, Science, 1956, 123, 309-314.
3. Weber G. Enzymology of cancer cells (first of two parts), N. Engl. J. Med., 1977, 296, 486-492.
4. Lee Y. J., Galoforo S. S., Berns C. M., Chen J. C., Davis B. H., Sim J. E., et al. Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells, J. Biol. Chem., 1998, 273, 5294-5299.
5. Spitz D. R., Sim J. E., Ridnour L. A., Galoforo S. S., Lee Y. J. Glucose Deprivation-Induced Oxidative Stress in Human Tumor Cells: A Fundamental Defect in Metabolism?, Ann. N. Y. Acad Sci., 2000, 899, 349-362.
6. Galoforo S. S., Berns C. M., Erdos G., Corry P. M., Lee Y. J. Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant human breast carcinoma MCF-7/ADR cells, Mol. Cell. Biochem., 1996, 155, 163-171.
7. Liu X., Gupta A. K., Corry P. M., Lee Y. J. Hypoglycemia-induced c-Jun Phosphorylation Is Mediated by c-Jun N-terminal Kinase 1 and Lyn Kinase in Drug-resistant Human Breast Carcinoma MCF-7/ADR Cells, J. Biol. Chem., 1997, 272, 11690-11693.
8. Wick A. N., Drury D. R., Nakada H. I., Wolfe J. B. Localization of The Primary Metabolic Block Produced by 2-Deoxyglucose, J. Biol. Chem., 1957, 224, 963-969.
9. Kern K., Norton J. Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-D-glucose, Surgery, 1987, 102, 380-385.
10. Dwarkanath B. S., Zolzer F., Chandana S., Bauch T., Adhikari J. S., Muller W. U., et al. Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines, Int. J. Radiat. Oncol. Biol. Phys., 2001, 50, 1051-1061.
11. Lin X., Zhang F., Bradbury C. M., Kaushal A., Li L., Spitz D. R., et al. 2-Deoxy-D-Glucose-induced Cytotoxicity and Radiosensitization in Tumor Cells Is Mediated via Disruptions in Thiol Metabolism, Cancer Res., 2003, 63, 3413-3417.
12. Jain V. K., Kalia V. K., Sharma R., Maharajan V., Menon M. Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells, Int. J. Radiat. Oncol. Biol. Phys., 1985, 11, 943-950.
13. Burger C., Wick M., Brusselbach S., Muller R. Differential induction of 'metabolic genes' after mitogen stimulation and during normal cell cycle progression, J. Cell. Sci., 1994, 107, 241-252.
14. Perez J. X., Roig T., Manzano A., Dalmau M., Boada J., Ventura F., et al. Overexpression of fructose 2, 6-bisphosphatase decreases glycolysis and delays cell cycle progression, Am. J. Physiol. Cell Physiol., 2000, 279, C1359-C1365.
15. Takanashi S., Bachur N. R. Adriamycin metabolism in man. Evidence from urinary metabolites, Drug Metab. Dispos., 1976, 4, 79-87.
16. Quiles J. L., Huertas J. R., Battino M., Mataix J., Ramírez-Tortosa M. C. Antioxidant nutrients and adriamycin toxicity, Toxicology, 2002, 180, 79-95.
17. Kong Q., Lillehei K. O. Antioxidant inhibitors for cancer therapy, Med. Hypotheses, 1998, 51, 405-409.
18. Gille L., Nohl H. Analyses of the Molecular Mechanism of Adriamycin-Induced Cardiotoxicity, Free Radic. Biol. Med., 1997, 23, 775-782.
19. Zhou S., Starkov A., Froberg M. K., Leino R. L., Wallace K. B. Cumulative and Irreversible Cardiac Mitochondrial Dysfunction Induced by Doxorubicin, Cancer Res, 2001, 61, 771-777.
20. Shenoy M. A., Singh B. B. Non-nitro Radiation Sensitizers, Int. J. Radiat. Biol., 1985, 48, 315-326.
21. Ahmad I. M., Abdalla M. Y., Aykin-Burns N., Simons A. L., Oberley L. W., Domann F. E., et al. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress, Free Radic. Biol. Med., 2008, 44, 826-834.
22. 2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation, Biochem. J., 2009, 418, 29-37.
23. Griffith O. W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine, Anal. Biochem., 1980, 106, 207-212.
24. Anderson M. Determination of glutathione and glutathione disulfide in biological samples, Meth. Enzymol., 1985, 113, 548-554.
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, J. Immunol. Meth., 1983, 65, 55-63.
26. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem., 1979, 95, 351-358.
27. Schafer F. Q., Buettner G. R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple, Free Radic. Biol. Med., 2001, 30, 1191-1212.
28. Sies H., Cadenas E., Symons M. C. R., Scott G. Oxidative Stress: Damage to Intact Cells and Organs, Philos. Trans. R. Soc. Lond. B Biol. Sci., 1985, 311, 617-631.
29. Oberley LW., Buettner G. R. Role of Superoxide Dismutase in Cancer: A Review, Cancer Res., 1979, 39, 1141-1149.
30. Suzuki M., O'Dea J. D., Suzuki T., Agar N. S. 2-deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells, Comp. Biochem. Physiol. Part B: Bioch. Mol. Biol., 1983, 75, 195-197.
31. Landau B. R., Lubs H. A. Animal responses to 2-Deoxy-d-Glucose administration, Proc. Soc. Exp. Biol. Med., 1958, 99, 124-127.
32. Andringa K. K., Coleman MC., Aykin-Burns N., Hitchler M. J., Walsh S. A., Domann F. E., et al. Inhibition of Glutamate Cysteine Ligase Activity Sensitizes Human Breast Cancer Cells to the Toxicity of 2-Deoxy-D-Glucose, Cancer Res., 2006, 66, 1605-1610.
33. Mohanti B. K., Rath G. K., Anantha N., Kannan V., Das B. S., Chandramouli B. A. R, et al. Improving cancer radiotherapy with 2-deoxy-glucose: Phase I/II clinical trials on human cerebral gliomas, Int. J. Radiat. Oncol., Biol., Phys., 1996, 35, 103-111.
34. Simons A. L., Ahmad I. M., Mattson D. M., Dornfeld K. J., Spitz D. R. 2-Deoxy-D-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells, Cancer Res., 2007, 67, 3364-3370.
35. Singh G., Lakkis CL., Laucirica R., Epner D. E. Regulation of prostate cancer cell division by glucose, J. Cell. Physiol., 1999, 180, 431-438.
36. Lo C-h., Cristofalo V. J., Morris H. P., Weinhouse S. Studies on Respiration and Glycolysis in Transplanted Hepatic Tumors of the Rat, Cancer Res., 1968, 28, 1-10.
37. Wang T., Marquardt C., Foker J. Aerobic glycolysis during lymphocyte proliferation, Nature, 1976, 261, 702-705.
38. Szatrowski T. P., Nathan C. F. Production of Large Amounts of Hydrogen Peroxide by Human Tumor Cells, Cancer Res., 1991, 51, 794-798.
39. Maschek G., Savaraj N., Priebe W., Braunschweiger P., Hamilton K., Tidmarsh G. F., et al. 2-Deoxy-D-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo, Cancer Res., 2004, 64, 31-34.
40. Wold L. E., Aberle N. S., Ren J. Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism, Cancer Detect. Prev., 2005, 29, 294-299.
41. Moadel R., Nguyen A., Lin E., Lu P., Mani J., Blaufox M. D., et al. Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer, Breast Cancer Res., 2003, 5, R199-R205.
42. Tyagi A. K., Singh R. P., Agarwal C., Chan D. C. F., Agarwal R. Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicininduced Growth Inhibition, G2-M Arrest, and Apoptosis, Clin. Cancer Res., 2002, 8, 3512-3519.
43. Bailey H. H. L-S, R-buthionine sulfoximine: historical development and clinical issues, Chem. Biol. Interact., 1998, 111-112, 239-254.
44. Hales B. F., Brown H. The effect of in vivo glutathione depletion with buthionine sulfoximine on rat embryo development, Teratology, 1991, 44, 251-257.
45. Meister A., Anderson M. E. Glutathione, Annu. Rev. Biochem., 1983, 52, 711-760.
46. Watanabe T., Sagisaka H., Arakawa S., Shibaya Y., Watanabe M., Igarashi I., et al. A Novel Model of Continuous Depletion of Glutathione in Mice Treated With L-Buthionine (S, R)-Sulfoximine, J. Toxicol. Sci., 2003, 28, 455-469.
47. Mattson D. M., Ahmad I. M., Dayal D., Parsons A. D., Aykin-Burns N., Li L., et al. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism, Free Radic. Biol. Med., 2009, 46, 232-237.