A phase I, dose-finding study of sunitinib in combination with irinotecan in patients with advanced solid tumours

British Journal of Cancer

Volumn 103, Issue 7, 2010, Pages 993-1000

  Boven, E ^a   Massard, C ^b   Armand, J P ^b   Tillier, C ^a   Hartog, V ^a   Brega, N M ^c   Countouriotis, A M ^c   Ruiz Garcia, A ^c   Soria, J C ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c PFIZER INC   (United States)

Author keywords

advanced solid tumours; combination; irinotecan; pharmacokinetics; sunitinib

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; IRINOTECAN; SU 012662; SUNITINIB; UNCLASSIFIED DRUG; CAMPTOTHECIN; INDOLE DERIVATIVE; PYRROLE DERIVATIVE;

ABDOMINAL PAIN; ADULT; AGED; ALOPECIA; ANEMIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BLEEDING; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HEADACHE; HUMAN; INFLAMMATION; LEUKOPENIA; LUNG NON SMALL CELL CANCER; MALE; MAXIMUM PLASMA CONCENTRATION; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUROLOGIC DISEASE; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SOLID TUMOR; THROMBOCYTOPENIA; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; DRUG ADMINISTRATION; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASMS; PATHOLOGY; TREATMENT OUTCOME;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INDOLES; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASMS; PYRROLES; TREATMENT OUTCOME;

EID: 77957220381     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605852     Document Type: Article

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