Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb

Drug Metabolism and Disposition

Volumn 38, Issue 10, 2010, Pages 1644-1647

  Genter, Mary Beth ^a   Krishan, Mansi ^a   Augustine, Lisa M ^b   Cherrington, Nathan J ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 3; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CATION TRANSPORT; CELLULAR DISTRIBUTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY; LIVER; MALE; NONHUMAN; NOSE MUCOSA; OLFACTORY BULB; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RESPIRATORY TRACT MUCOSA; RNA ISOLATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL TRANSPORT; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NASAL MUCOSA; NUCLEOSIDES; OLFACTORY BULB; OLFACTORY MUCOSA; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 77957167850     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034611     Document Type: Article

References (21)

1. Alanko L, Porkka-Heiskanen T, and Soinila S (2006) Localization of equilibrative nucleoside transporters in the rat brain. J Chem Neuroanat 31:162-168.
2. Chemuturi NV and Donovan MD (2007) Role of organic cation transporters in dopamine uptake across olfactory and nasal respiratory tissues. Mol Pharm 4:936-942.
3. Cherrington NJ, Slitt AL, Li N, and Klaassen CD (2004) Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 32:734-741. (Pubitemid 38821875)
4. Dorman DC, Brenneman KA, McElveen AM, Lynch SE, Roberts KC, and Wong BA (2002) Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. J Toxicol Environ Health A 65:1493-1511.
5. Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J, and Unadkat JD (2009) Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol 296:G910-G922.
6. Genter MB, Burman DM, Vijayakumar S, Ebert CL, and Aronow BJ (2002) Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiol Genomics 12:35-45. (Pubitemid 37139681)
7. Genter MB, Kendig EL, and Knutson MD (2009) Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Ann NY Acad Sci 1170:623-628.
8. Jennings LL, Hao C, Cabrita MA, Vickers MF, Baldwin SA, Young JD, and Cass CE (2001) Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system. Neuropharmacology 40:722-731. (Pubitemid 32323996)
9. Kikuchi A, Nozawa T, Wakasawa T, Maeda T, and Tamai I (2006) Transporter-mediated intestinal absorption of fexofenadine in rats. Drug Metab Pharmacokinet 21:308-314.
10. Kinoshita Y, Shiga H, Washiyama K, Ogawa D, Amano R, Ito M, Tsukatani T, Furukawa M, and Miwa T (2008) Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulb. Chem Senses 33:73-78.
11. Natsume H, Iwata S, Ohtake K, Miyamoto M, Yamaguchi M, Hosoya K, Kobayashi D, Sugibayashi K, and Morimoto Y (1999) Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int J Pharm 185:1-12.
12. Ohtsuki S, Takizawa T, Takanaga H, Hori S, Hosoya K, and Terasaki T (2004) Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells. J Neurochem 90:743-749. (Pubitemid 38989406)
13. Paternostro MA and Meisami E (1996) Essential role of thyroid hormones in maturation of olfactory receptor neurons: an immunocytochemical study of number and cytoarchitecture of OMP-positive cells in developing rats. Int J Dev Neurosci 14:867-880.
14. Seki T, Sato N, Hasegawa T, Kawaguchi T, and Juni K (1994) Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats. Biol Pharm Bull 17:1135-1137. (Pubitemid 24276359)
15. Thompson K, Molina RM, Donaghey T, Schwob JE, Brain JD, and Wessling-Resnick M (2007) Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. FASEB J 21:223-230. (Pubitemid 46052560)
16. Tong H, Chen GH, Liu RY, and Zhou JN (2007) Age-related learning and memory impairments in adult-onset hypothyroidism in Kunming mice. Physiol Behav 91:290-298. (Pubitemid 46770809)
17. Türker S, Onur E, and Ozer Y (2004) Nasal route and drug delivery systems. Pharm World Sci 26:137-142. (Pubitemid 39012580)
18. Varatharajan L and Thomas SA (2009) The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res 82:A99-A109; erratum in Antiviral Res 2009 84:203.
19. Wetmore BA, Mitchell AD, Meyer SA, and Genter MB (1999) Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicol Sci 49:202-212.
20. Wioland MA, Fleury-Feith J, Corlieu P, Commo F, Monceaux G, Lacau-St-Guily J, and Bernaudin JF (2000) CFTR, MDR1, and MRP1 immunolocalization in normal human nasal respiratory mucosa. J Histochem Cytochem 48:1215-1222.
21. Yajima T, Hasegawa T, Juni K, Saneyoshi M, and Kawaguchi T (1996) Nasal absorption of 2′,3′-didehydro-3′-deoxythymidine (D4T) and its esters in rats. Biol Pharm Bull 19:1234-1237. (Pubitemid 26342272)