Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats

Drug Metabolism and Disposition

Volumn 38, Issue 10, 2010, Pages 1865-1875

  Thiebaud, Nicolas ^a   Sigoillot, Maud ^a   Chevalier, Joëlle ^a   Artur, Yves ^a   Heydel, Jean Marie ^a   Le Bon, Anne Marie ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; AROCLOR 1242; AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A; CYTOCHROME P450 2A; CYTOCHROME P450 3A; DEXAMETHASONE; DRUG METABOLIZING ENZYME; ETHOXYQUIN; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFOTRANSFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; URIDINE DIPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; GENE EXPRESSION; LIVER; MALE; NONHUMAN; OLFACTORY EPITHELIUM; PEROXISOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; TISSUE SPECIFICITY; UPREGULATION;

ANIMALS; CYTOCHROMES; CYTOSOL; DOWN-REGULATION; ENZYME INDUCTION; MALE; MEMBRANE TRANSPORT PROTEINS; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MICROSOMES, LIVER; OLFACTORY MUCOSA; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; UP-REGULATION; XENOBIOTICS;

MAMMALIA; RATTUS;

EID: 77957148873     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.035014     Document Type: Article

References (40)

1. Baldwin RM, Jewell WT, Fanucchi MV, Plopper CG, and Buckpitt AR (2004) Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque. J Pharmacol Exp Ther 309:127-136.
2. Banger KK, Lock EA, and Reed CJ (1996) Regulation of rat olfactory glutathione S-transferase expression. Investigation of sex differences, induction, and ontogenesis. Biochem Pharmacol 52:801-808.
3. Beckmann JD, Bartzatt R, Ulphani J, Palmatier R, and Sisson JH (1995) Phenol sulfotransferase activities and localization in human nasal polyp epithelium. Biochem Biophys Res Commun 213:104-111.
4. Ben-Arie N, Khen M, and Lancet D (1993) Glutathione S-transferases in rat olfactory epithelium: purification, molecular properties and odorant biotransformation. Biochem J 292:379-384. (Pubitemid 23181948)
5. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
6. Ding X and Dahl AR (2003) Olfactory mucosa: composition, enzymatic localization and metabolism, in Handbook of Olfaction and Gustation (Doty RL, ed) pp 51-73, Marcel Dekker, New York.
7. Ding X, Peng HM, and Coon MJ (1992) Cytochromes P450 NMa, NMb (2G1), and LM4 (1A2) are differentially expressed during development in rabbit olfactory mucosa and liver. Mol Pharmacol 42:1027-1032. (Pubitemid 23028839)
8. Ding XX and Coon MJ (1990) Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone. Drug Metab Dispos 18:742-745.
9. Dunn RT 2nd and Klaassen CD (1998) Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug Metab Dispos 26:598-604. (Pubitemid 28498367)
10. Genter MB, Apparaju S, and Desai PB (2002) Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biochem Mol Toxicol 16:128-134. (Pubitemid 34752482)
11. Haber D, Siess MH, de Waziers I, Beaune P, and Suschetet M (1994) Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides. Xenobiotica 24:169-182. (Pubitemid 24104503)
12. Heydel JM, Holsztynska EJ, Legendre A, Thiebaud N, Artur Y, and Le Bon AM (2010) UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function. Drug Metab Rev 42:71-94.
13. Honkakoski P and Negishi M (1998) Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J Biochem Mol Toxicol 12:3-9. (Pubitemid 128501112)
14. Jedlitschky G, Cassidy AJ, Sales M, Pratt N, and Burchell B (1999) Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. Biochem J 340:837-843. (Pubitemid 29312884)
15. Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M, Wu W, Eraly SA, and Nigam SK (2006) Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun 351:872-876. (Pubitemid 44715866)
16. Kratskin IL, Kimura Y, Hastings L, and Doty RL (1999) Chronic dexamethasone treatment potentiates insult to olfactory receptor cells produced by 3-methylindole. Brain Res 847:240-246.
17. Kudo H, Doi Y, and Fujimoto S (2010) Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium: a possible role in the phase III xenobiotic metabolizing function. Neurosci Lett 468:98-101.
18. Ling G, Hauer CR, Gronostajski RM, Pentecost BT, and Ding X (2004) Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo. J Biol Chem 279:27888-27895. (Pubitemid 38900057)
19. Liu C, Zhuo XL, Gonzalez FJ, and Ding XX (1996) Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2A6: role in metabolic activation of nasal toxicants. Mol Pharm 50:781-788. (Pubitemid 26347697)
20. Liu L and Klaassen CD (1996) Regulation of hepatic sulfotransferases by steroidal chemicals in rats. Drug Metab Dispos 24:854-858. (Pubitemid 26274742)
21. Longo V, Citti L, and Gervasi PG (1988) Biotransformation enzymes in nasal mucosa and liver of Sprague-Dawley rats. Toxicol Lett 44:289-297. (Pubitemid 19007341)
22. Ma Q, Kinneer K, Bi Y, Chan JY, and Kan YW (2004) Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. Biochem J 377:205-213. (Pubitemid 38114447)
23. Mayer U, Ungerer N, Klimmeck D, Warnken U, Schnölzer M, Frings S, and Möhrlen F (2008) Proteomic analysis of a membrane preparation from rat olfactory sensory cilia. Chem Senses 33:145-162. (Pubitemid 351308799)
24. Messina A, Nannelli A, Fiorio R, Longo V, and Gervasi PG (2009) Expression and inducibility of CYP1A1, 1A2, 1B1 by beta-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicology 260:47-52.
25. Miao W, Hu L, Scrivens PJ, and Batist G (2005) Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J Biol Chem 280:20340-20348. (Pubitemid 40776732)
26. Minn A, Leclerc S, Heydel JM, Minn AL, Denizcot C, Cattarelli M, Netter P, and Gradinaru D (2002) Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier. J Drug Target 10:285-296. (Pubitemid 34746310)
27. Minn AL, Pelczar H, Denizot C, Martinet M, Heydel JM, Walther B, Minn A, Goudonnet H, and Artur Y (2005) Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. Drug Metab Dispos 33:1229-1237. (Pubitemid 41043767)
28. Monte JC, Nagle MA, Eraly SA, and Nigam SK (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429-436. (Pubitemid 39221116)
29. Osburn WO and Kensler TW (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 659:31-39.
30. Quattrochi LC and Guzelian PS (2001) CYP3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos 29:615-622. (Pubitemid 32374560)
31. Shelby MK, Cherrington NJ, Vansell NR, and Klaassen CD (2003) Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metab Dispos 31:326-333. (Pubitemid 36249688)
32. Stenner M, Vent J, Hüttenbrink KB, Hummel T, and Damm M (2008) Topical therapy in anosmia: relevance of steroid-responsiveness. Laryngoscope 118:1681-1686.
33. Stohs SJ and Wu CL (1982) Effect of various xenobiotics and steroids on aryl-hydrocarbon hydroxylase-activity of intestinal and hepatic microsomes from male rats. Pharmacology 25:237-249.
34. Su T, Sheng JJ, Lipinskas TW, and Ding X (1996) Expression of CYP2A genes in rodent and human nasal mucosa. Drug Metab Dispos 24:884-890. (Pubitemid 26274747)
35. Tamura HO, Harada Y, Miyawaki A, Mikoshiba K, and Matsui M (1998) Molecular cloning and expression of a cDNA encoding an olfactory-specific mouse phenol sulphotransferase. Biochem J 331:953-958. (Pubitemid 28211922)
36. Thornton-Manning J, Appleton ML, Gonzalez FJ, and Yost GS (1996) Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. J Pharmacol Exp Ther 276:21-29. (Pubitemid 26150948)
37. Voigt JM, Guengerich FP, and Baron J (1993) Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J Histochem Cytochem 41:877-885.
38. Wardlaw SA, Nikula KJ, Kracko DA, Finch GL, Thornton-Manning JR, and Dahl AR (1998) Effect of cigarette smoke on CYP1A1, CYP1A2 and CYP2B1/2 of nasal mucosae in F344 rats. Carcinogenesis 19:655-662.
39. Xu C, Li CY, and Kong AN (2005) Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 28:249-268. (Pubitemid 44698742)
40. Zhang J, Zhang QY, Guo J, Zhou Y, and Ding X (2000) Identification and functional characterization of a conserved, nuclear factor 1-like element in the proximal promoter region of CYP1A2 gene specifically expressed in the liver and olfactory mucosa. J Biol Chem 275: 8895-8902. (Pubitemid 30180246)