SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells

FEBS Letters

Volumn 584, Issue 19, 2010, Pages 4241-4246

  Cha, Young ^a   Park, Kyung Soon ^a  

^a CHA University   (South Korea)

Author keywords

ERK1 2; LIF receptor; Self renewal; SHP2; ZAP70

Indexed keywords

JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 77957124182     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.09.016     Document Type: Article

References (21)

1. Williams R.L., et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988, 336:684-687.
2. Davis S., Aldrich T.H., Stahl N., Pan L., Taga T., Kishimoto T., Ip N.Y., Yancopoulos G.D. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 1993, 260:1805-1808.
3. Gearing D.P., et al. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991, 10:2839-2848.
4. Anneren C., Cowan C.A., Melton D.A. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J. Biol. Chem. 2004, 279:31590-31598.
5. Raz R., Lee C.K., Cannizzaro L.A., d'Eustachio P., Levy D.E. Essential role of STAT3 for embryonic stem cell pluripotency. Proc. Natl. Acad. Sci. USA 1999, 96:2846-2851.
6. Xu D., Qu C.K. Protein tyrosine phosphatases in the JAK/STAT pathway. Front Biosci. 2008, 13:4925-4932.
7. Burdon T., Stracey C., Chambers I., Nichols J., Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 1999, 210:30-43.
8. Nichols J., Silva J., Roode M., Smith A. Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development 2009, 136:3215-3222.
9. Feng G.S. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp. Cell Res. 1999, 253:47-54.
10. Neel B.G., Gu H., Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 2003, 28:284-293.
11. Chan R.J., Johnson S.A., Li Y., Yoder M.C., Feng G.S. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood 2003, 102:2074-2080.
12. Qu C.K., Feng G.S. Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene 1998, 17:433-439.
13. Wu D., et al. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS ONE 2009, 4:e4914.
14. Chan A.C., Iwashima M., Turck C.W., Weiss A. ZAP-70: a 70kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992, 71:649-662.
15. Cha, Y. et al. (2010) Zap70 functions to maintain stemness of mouse embryonic stem cells negatively regulating Jak1/Stat3/c-Myc signaling. Stem Cells. Epub a head of print.
16. Cha H., Wang X., Li H., Fornace A.J. A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J. Biol. Chem. 2007, 282:22984-22992.
17. Lu W., Gong D., Bar-Sagi D., Cole P.A. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol. Cell 2001, 8:759-769.
18. Su L., Rickert R.C., David M. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J. Biol. Chem. 1999, 274:31770-31774.
19. Port M.D., Laszlo G.S., Nathanson N.M. Transregulation of leukemia inhibitory [corrected] factor receptor expression and function by growth factors in neuroblastoma cells. J. Neurochem. 2008, 106:1941-1951.
20. Feng G.S. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res 2007, 17:37-41.
21. Hanafusa H., Torii S., Yasunaga T., Matsumoto K., Nishida E. Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J. Biol. Chem. 2004, 279:22992-22995.