Fate of chemicals in skin after dermal application: Does the in vitro skin reservoir affect the estimate of systemic absorption?

Toxicology and Applied Pharmacology

Volumn 195, Issue 3, 2004, Pages 309-320

  Yourick, Jeffrey J ^a   Koenig, Michael L ^b   Yourick, Debra L ^b   Bronaugh, Robert L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

7 (2H Naphtho 1,2 d triazol 2 yl) 3 phenylcoumarin; Absorption; Chemicals; Cosmetic; Dermal penetration; Dihydroxyacetone; Disperse blue 1; Hair dye; Human skin; Rat skin; Skin; Skin absorption; Skin reservoir

Indexed keywords

7 (2H NAPHTHO[1,2 D]TRIAZOL 2 YL) 3 PHENYLCOUMARIN; COUMARIN DERIVATIVE; DIHYDROXYACETONE; DISPERSE BLUE 1; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOMETRY; DERMIS; DIFFUSION; EPIDERMIS; FEMALE; FLUORESCENCE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; RAT; SKIN ABSORPTION; SKIN PENETRATION; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTHRAQUINONES; COUMARINS; DIHYDROXYACETONE; FEMALE; HUMANS; RATS; SKIN; SKIN ABSORPTION; TISSUE DISTRIBUTION; TRIAZOLES;

ANIMALIA;

EID: 1542512383     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.07.015     Document Type: Article

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