Genital epithelial cells: Foot soldiers or fashion leaders?

Journal of Leukocyte Biology

Volumn 88, Issue 3, 2010, Pages 427-429

  Kaul, R ^a,b,c   Hirbod, T ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adaptive immunity; Epithelial cells; Genital tract dendritic cells; HIV; HPV; Innate immunity; Tolerance

Indexed keywords

CATHELICIDIN; CD4 ANTIGEN; CHEMOKINE; CYTOKINE; DEFENSIN; HLA ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ADAPTIVE IMMUNITY; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; CARCINOGENESIS; CD4+ T LYMPHOCYTE; CELL SUBPOPULATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; EDITORIAL; EMBRYO TRANSFER; EPITHELIUM CELL; FEMALE GENITAL SYSTEM; FEMALE INFERTILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SEXUAL BEHAVIOR; TRICHOMONAS VAGINALIS; UTERINE CERVIX CANCER; VAGINA EPITHELIUM; VIRUS INFECTION; VIRUS TRANSMISSION; WART VIRUS;

ADAPTIVE IMMUNITY; EPITHELIAL CELLS; FEMALE; GENITALIA; HUMANS;

HUMAN PAPILLOMAVIRUS;

EID: 77957108572     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0410230     Document Type: Editorial

References (16)

1. Wira, C. R., Grant-Tschudy, K. S., Crane-Godreau, M. A. (2005) Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am. J. Reprod. Immunol. 53, 65-76.
2. Ochiel, D. O., Ghosh, M., Fahey, J. V., Guyre, P. M., Wira, C. R. (2010) Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands. J. Leukoc. Biol., 88, 435-444.
3. Kaushic, C. (2009) The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract. J. Reprod. Immunol. 83, 168-172.
4. Hladik, F., Hope, T. J. (2009) HIV infection of the genital mucosa in women. Curr. HIV/AIDS Rep. 6, 20-28.
5. Iqbal, S. M., Kaul, R. (2008) Mucosal innate immunity as a determinant of HIV susceptibility. Am. J. Reprod. Immunol. 59, 44-54. (Pubitemid 350285582)
6. Mestecky, J., Moldoveanu, Z., Russell, M. W. (2005) Immunologic uniqueness of the genital tract: challenge for vaccine development. Am. J. Reprod. Immunol. 53, 208-214. (Pubitemid 40542802)
7. Iijima, N., Thompson, J. M., Iwasaki, A. (2008) Dendritic cells and macrophages in the genitourinary tract. Mucosal Immunol. 1, 451-459.
8. Hirbod, T., Kaldensjo, T., Lopalco, L., Klareskog, E., Andersson, S., Uberti-Foppa, C., Ferrari, D., Manghi, M., Andersson, J., Lore, K., Broliden, K. (2009) Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection. J. Acquir. Immune Defic. Syndr. 51, 239-247.
9. Wira, C. R., Fahey, J. V., Ghosh, M., Patel, M. V., Hickey, D. K., Ochiel, D. O. (2010) Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens. Am. J. Reprod. Immunol., Epub ahead of print.
10. Einstein, M. H., Schiller, J. T., Viscidi, R. P., Strickler, H. D., Coursaget, P., Tan, T., Halsey, N., Jenkins, D. (2009) Clinician's guide to human papillomavirus immunology: knowns and unknowns. Lancet Infect. Dis. 9, 347-356.
11. Van der Burg, S. H., Piersma, S. J., de Jong, A., van der Hulst, J. M., Kwappenberg, K. M., van den Hende, M., Welters, M. J., Van Rood, J. J., Fleuren, G. J., Melief, C. J., Kenter, G. G., Offringa, R. (2007) Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens. Proc. Natl. Acad. Sci. USA 104, 12087-12092.
12. Watts, D. H., Fazzari, M., Minkoff, H., Hillier, S. L., Sha, B., Glesby, M., Levine, A. M., Burk, R., Palefsky, J. M., Moxley, M., Ahdieh-Grant, L., Strickler, H. D. (2005) Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women. J. Infect. Dis. 191, 1129-1139.
13. Nazli, A., Chan, O., Dobson-Belaire, W. N., Ouellet, M., Tremblay, M. J., Gray-Owen, S. D., Arsenault, A. L., Kaushic, C. (2010) Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog. 6, e1000852.
14. Haase, A. T. (2010) Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464, 217-223.
15. Levinson, P., Kaul, R., Kimani, J., Ngugi, E., Moses, S., MacDonald, K. S., Broliden, K., Hirbod, T. (2009) Levels of innate immune factors in genital fluids: association of α defensins and LL-37 with genital infections and increased HIV acquisition. AIDS 23, 309-317.
16. Card, C. M., McLaren, P. J., Wachihi, C., Kimani, J., Plummer, F. A., Fowke, K. R. (2009) Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells. J. Infect. Dis. 199, 1318-1322.