The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract

Journal of Reproductive Immunology

Volumn 83, Issue 1-2, 2009, Pages 168-172

  Kaushic, Charu ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Epithelial cell; Genital tract; Immune response; Sex hormones; Sexually transmitted virus

Indexed keywords

ESTROGEN; PROGESTERONE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ACTIVITY; DISEASE PREDISPOSITION; EPITHELIUM CELL; FEMALE; FEMALE GENITAL TRACT INFECTION; HORMONE ACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; IMMUNOREGULATION; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; SEXUALLY TRANSMITTED DISEASE; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS TRANSMISSION;

CELL COMMUNICATION; DISEASE SUSCEPTIBILITY; FEMALE; GENITALIA, FEMALE; GONADAL STEROID HORMONES; HUMANS; IMMUNITY; PREVALENCE; RISK FACTORS; SEX FACTORS; SEXUALLY TRANSMITTED DISEASES, VIRAL;

EID: 70450247049     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.08.010     Document Type: Article

References (48)

1. Andersen J.M., Al-Khairy D., and Ingalls R.R. Innate immunity at the mucosal surface: role of toll-like receptor 3 and toll-like receptor 9 in cervical epithelial cell responses to microbial pathogens. Biol. Reprod. 74 (2006) 824-831
2. Ashkar A.A., Bauer S., Mitchell W.J., Vieira J., and Rosenthal K.L. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 77 (2003) 8948-8956
3. Asin S.N., Fanger M.W., Wildt-Perinic D., Ware P.L., Wira C.R., and Howell A.L. Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblasts. J. Infect. Dis. 190 (2004) 236-245
4. Bhavanam S., Snider D.P., and Kaushic C. Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone. Vaccine 26 (2008) 6165-6172
5. Bobardt M.D., Chatterji U., Selvarajah S., Van Der Schueren B., David G., Kahn B., and Gallay P.A. Cell-free human immunodeficiency virus type 1 transcytosis through primary genital epithelial cells. J. Virol. 81 (2007) 395-405
6. Bouschbacher M., Bomsel M., Verronese E., Gofflo S., Ganor Y., Dezutter-Dambuyant C., and Valladeau J. Early events in HIV transmission through a human reconstructed vaginal mucosa. Aids 22 (2008) 1257-1266
7. Brabin L. Interactions of female hormonal environment, susceptibility to viral infection and disease progression. AIDS Patient Care STDS 16 (2002) 211-221
8. Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., Kazzaz Z., Bornstein E., Lambotte O., Altmann D., Blazar B.R., Rodriguez B., Teixeira-Johnson L., Landay A., Martin J.N., Hecht F.M., Picker L.J., Lederman M.M., Deeks S.G., and Douek D.C. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12 (2006) 1365-1371
9. Center for Disease Control and Prevention, C., 2009. Trends in Reportable sexually transmitted diseases in the United States, 2007. Available at: http://www.cdc.gov/std/stats07.
10. Coombs R.W., Reichelderfer P.S., and Landay A.L. Recent observations on HIV type-1 infection in the genital tract of men and women. Aids 17 (2003) 455-480
11. Corey L., and Wald A. Genital Herpes. In: Holmes K.K., Sparling P.F., Mardh P.A., Lemon S.M., Stamm W.E., Piot P., and Wasserheit J.N. (Eds). Sexually Transmitted Diseases. third ed. (1999), McGraw-Hill, New York
12. Fichorova R.N., Cronin A.O., Lien E., Anderson D.J., and Ingalls R.R. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of Toll-like Receptor 4-mediated signaling. J. Immunol. 168 (2002) 2424-2432
13. Fox-Canale A.M., Hope T.J., Martinson J., Lurain J.R., Rademaker A.W., Bremer J.W., Landay A., Spear G.T., and Lurain N.S. Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue. Virology 369 (2007) 55-68
14. Geijtenbeek T.B., Kwon D.S., Torensma R., and Al E. DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances trans-infection of T-cells. Cell 100 (2000) 587-597
15. Gillgrass A.E., Ashkar A.A., Rosenthal K.L., and Kaushic C. Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J. Virol. 77 (2003) 9845-9851
16. Gillgrass A.E., Fernandez S.A., Rosenthal K.L., and Kaushic C. Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammation. J. Virol. 79 (2005) 3107-3116
17. Gillgrass A.E., Tang V.A., Towarnicki K.M., Rosenthal K.L., and Kaushic C. Protection against genital herpes infection in mice immunized under different hormonal conditions correlates with induction of vagina-associated lymphoid tissue. J. Virol. 79 (2005) 3117-3126
18. Herbst-Kralovetz M.M., and Pyles R.B. Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection. J. Virol. 80 (2006) 9988-9997
19. Hladik F., Sakchalathorn P., Ballweber L., Lentz G., Fialkow M., Eschenbach D., and McElrath M.J. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 26 (2007) 257-270
20. Kaushic C., Murdin A.D., Underdown B.J., and Wira C.R. Chlamydia trachomatis infection in the female reproductive tract of rat: influence of progesterone on infectivity and immune response. Infect. Immun. 66 (1998) 893-898
21. Kaushic C., Zhou F., Murdin A.D., and Wira C.R. Effect of estradiol and progesterone on susceptibility and immune responses to Chlamydia trachomatis infection in the female reproductive tract. Infect. Immun. 68 (2000) 4207-4216
22. Kaushic C., Ashkar A.A., Reid L.A., and Rosenthal K.L. Progesterone increases susceptibility and decreases immune responses to genital herpes infection. J. Virol. 77 (2003) 4558-4565
23. Lavreys L., Baeten J.M., Martin Jr. H.L., Overbaugh J., Mandaliya K., Ndinya-Achola J., and Kreiss J.K. Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective study. Aids 18 (2004) 695-697
24. Looker K.J., Garnett G.P., and Schmid G.P. An estimate of global prevalence and incidence of herpes simplex virus type 2 infection. Bull. World Health Organ. 86 (2008) 737-816
25. Macdonald E.M., Savoy A., Gillgrass A., Fernandez S., Smieja M., Rosenthal K.L., Ashkar A.A., and Kaushic C. Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection. Biol. Reprod. 77 (2007) 1049-1059
26. Maher D., Wu X., Schacker T., Horbul J., and Southern P. HIV binding, penetration, and primary infection in human cervicovaginal tissue. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 11504-11509
27. Maher D.M., Zhang Z.Q., Schacker T.W., and Southern P.J. Ex vivo modeling of oral HIV transmission in human palatine tonsil. J. Histochem. Cytochem. 53 (2005) 631-642
28. Medzhitov R., and Janeway Jr. C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 (1997) 295-298
29. Miller C.J., and Shattock R.J. Target cells in vaginal HIV transmission. Microbes Infect. 5 (2003) 59-67
30. Miller L., Patton D.L., Meier A., Thwin S.S., Hooton T.M., and Eschenbach D.A. Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium. Obstet. Gynecol. 96 (2000) 431-439
31. Moss G.B., Clemetson D., D'costa L., Plummer F.A., Ndinya-Achola J.O., Reilly M., Holmes K.K., Piot P., Maitha G.M., Hillier S.L., et al. Association of cervical ectopy with heterosexual transmission of human immunodeficiency virus: results of a study of couples in Nairobi, Kenya. J. Infect. Dis. 164 (1991) 588-591
32. Mostad S.B., Kreiss J.K., Ryncarz A.J., Mandaliya K., Chohan B., Ndinya-Achola J., Bwayo J.J., and Corey L. Cervical shedding of herpes simplex virus in human immunodeficiency virus-infected women: effects of hormonal contraception, pregnancy, and vitamin A deficiency. J. Infect. Dis. 181 (2000) 58-63
33. Nazli A., Yao X.D., Smieja M., Rosenthal K.L., Ashkar A.A., and Kaushic C. Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women. Antiviral Res. 81 (2009) 103-112
34. Parr M.B., and Parr E.L. Vaginal immunity in the HSV-2 mouse model. Int. Rev. Immunol. 22 (2003) 43-63
35. Paz-Bailey G., Ramaswamy M., Hawkes S.J., and Geretti A.M. Herpes simplex virus type 2: epidemiology and management options in developing countries. Sex Trans. Infect. 83 (2007) 16-22
36. Philips D.M., and Bourinbaiar A.S. Mechanism of HIV spread from lymphocytes to epithelia. Virology 186 (1992) 261-273
37. Prakash M., Kapembwa M.S., Gotch F., and Patterson S. Oral contraceptive use induces upregulation of CCR5 chemokine receptor in the cervical epithelium of healthy women. J. Reprod. Immunol. 54 (2002) 117-131
38. Pudney J., Quayle A.J., and Anderson D.J. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol. Reprod. 73 (2005) 1253-1263
39. Quayle A.J. The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. J. Reprod. Immunol. 57 (2002) 61-79
40. Quinn T.C., Wawer M.J., Sewankambo N., and Al E. Viral load and heterosexual transmission of HIV-1. Rakai project Study Group. N. Engl. J. Med. 342 (2000) 921-929
41. Schaefer T.M., Fahey J.V., Wright J.A., and Wira C.R. Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C). J. Immunol. 174 (2005) 992-1002
42. Stoddard E., Cannon G., Ni H., Kariko K., Capodici J., Malamud D., and Weissman D. gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J. Immunol. 179 (2007) 3126-3132
43. Tengvall S., Josefsson A., Holmgren J., and Harandi A.M. CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice. J. Reprod. Immunol. 68 (2005) 53-69
44. Turville S.G., Cameron P.U., Handley A., Lin G., Pohlmann S., Doms R.W., and Cunningham A.L. Diversity of receptors binding HIV on dendritic cell subsets. Nat. Immunol. 3 (2002) 975-983
45. Unaids, 2008. UNAIDS Report on AIDS Epidemic, July 2008.
46. Wang C.C., Mcclelland R.S., Overbaugh J., Reilly M., Panteleeff D.D., Mandaliya K., Chohan B., Lavreys L., Ndinya-Achola J., and Kreiss J.K. The effect of hormonal contraception on genital tract shedding of HIV-1. Aids 18 (2004) 205-209
47. Wira C.R., Kaushic C., and Richardson J. Role of sex hormones and cytokines in regulating mucosal immune system in the female reproductive tract. In: Ogra P.L., Mestecky J., Lamm M.E., Strober W., Bienenstock J., and McGhee J.R. (Eds). Mucosal Immunity. second ed. (1999), Academic Press, San Diego
48. Wira C.R., Grant-Tschudy K.S., and Crane-Godreau M.A. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am. J. Reprod. Immunol. 53 (2005) 65-76