Molecular mechanisms, and selective pharmacological rescue, of rem-inhibited CaV1.2 channels in heart

Circulation Research

Volumn 107, Issue 5, 2010, Pages 620-630

  Xu, Xianghua ^a   Marx, Steven O ^a   Colecraft, Henry M ^a  

^a Department of Physiology and Cellular Biophysics ^*  (United States)

Author keywords

cardiac myocytes; L type calcium channels; Rem; RGK GTPase

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ADENOVIRUS VECTOR; CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL STIMULATING AGENT; HYBRID PROTEIN; L TYPE CALCIUM CHANNEL ALPHA(1C); L-TYPE CALCIUM CHANNEL ALPHA(1C); MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CALCIUM HOMEOSTASIS; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GUINEA PIG; HEART CELL CULTURE; HEART CONTRACTION; HEART EXCITATION; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE POTENTIAL; IMMUNOFLUORESCENCE; MALE; MOLECULAR INTERACTION; MUSCLE CELL; NONHUMAN; NUCLEOTIDE BINDING SITE; ONCOGENE H RAS; OUTCOME ASSESSMENT; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; ACTION POTENTIAL; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CALCIUM SIGNALING; CELL CULTURE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETICS; HEART MUSCLE CELL; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN TRANSPORT; TIME;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GUANOSINE TRIPHOSPHATE; GUINEA PIGS; ION CHANNEL GATING; MALE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; MUTATION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 77957065470     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.224717     Document Type: Article

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