Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957

Nuclear Medicine and Biology

Volumn 37, Issue 7, 2010, Pages 837-843

  Palner, Mikael ^a,b   McCormick, Patrick ^c   Parkes, Jun ^c   Knudsen, Gitte M ^a,b   Wilson, Alan A ^c,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Agonist; Catechol O methyltransferase; Dopamine D1 receptor; Entacapone; Ex vivo; Metabolites; PET Tracer; R 11C SKF 82957; Tolcapone

Indexed keywords

3 METHYL 6 CHLORO 7,8 DIHYDROXY 1 PHENYL 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPINE C 11; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AMPHETAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE UPTAKE INHIBITOR; ENTACAPONE; METIROSINE; RTI 32; TOLCAPONE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG STRUCTURE; DRUG UPTAKE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE TRACING; MALE; MOLECULAR IMAGING; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; SENSITIVITY AND SPECIFICITY;

ANIMALS; BENZAZEPINES; BENZOPHENONES; BRAIN; CARBON RADIOISOTOPES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; DOPAMINE AGONISTS; ENZYME INHIBITORS; NITRILES; NITROPHENOLS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RECEPTORS, DOPAMINE D1; TISSUE DISTRIBUTION;

EID: 77957006856     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.04.193     Document Type: Article

References (34)

1. 1 receptors in prefrontal cortex. Nature 1995, 376:572-575.
2. 1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology 1994, 116:143-151.
3. 1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci 1998, 18:1613-1621.
4. 1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology 2004, 174:3-16.
5. 1 receptors in twins discordant for schizophrenia. Am J Psychiat 2006, 163:1747-1753.
6. 11C-raclopride. Psychopharmacology 1987, 92:278-284.
7. 1-dopamine receptors. J Nucl Med 1998, 39:2061-2068.
8. 11C]NNC 756, dopamine D-1 receptor ligands. Preparation, autoradiography and PET investigation in monkey. Nucl Med Biol 1993, 20:945-953.
9. Laihinen A.O., Rinne J.O., Ruottinen H.M., Någren K.A., Lehikoinen P.K., Oikonen V.J., et al. J Nucl Med 1994, 35:1916-1920.
10. Besret L., Dollé F., Hérard A., Guillermier M., Demphel S., Hinnen F., et al. J Pharm Sci 2008, 97:2811-2819.
11. 1 receptors. Nucl Med Biol 1995, 22:221-226.
12. Yang Z.Y., Perry B., Mukherjee J. Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nucl Med Biol 1996, 23:793-805.
13. 1 receptors: effect of dopamine. Eur J Pharm 1994, 268:79-88.
14. 1 dopamine receptor ligand: synthesis and structure-activity relationship. J Med Chem 1991, 34:3366-3371.
15. 11C]SKF 82957: synthesis and in vivo characterization in rats. Nucl Med Biol 1999, 26:537-542.
16. 11C]SKF 82957 as potential PET radioligands. Appl Radiat Isotopes 1996, 47:279-284.
17. 11C]SKF 82957 in rat brain: two dopamine D-1 receptor agonist ligands. Life Sci 1996, 58:1661-1670.
18. 11C]SKF 82957 produces a radiolabeled metabolite in rat brain. J Label Compd Radiopharm 2003, 46:S365-S382.
19. Männistö P.T., Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 1999, 51:593-628.
20. Pfeiffer F.R., Wilson J.W., Weinstock J., Kuo G.Y., Chambers P.A., Holden K.G., et al. Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. J Med Chem 1982, 25:352-358.
21. 11C]N-methyl-NNC 01-0259. NeuroImage 2008, 41:T-T91.
22. 11CH3]-carbomethoxy-3β-aryltropanes: radiotracers for the dopamine transporter. J Label Compd Radiopharm 1994, 34:759-765.
23. 18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. Nucl Med Biol 1996, 23:141-146.
24. Wilson A.A., Garcia A., Jin L., Houle S. Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method. Nucl Med Biol 2000, 27:529-532.
25. 11C]-methylation reactions. J Label Compd Radiopharm 2009, 52:490-492.
26. Hilton J., Yokoi F., Dannals R.F., Ravert H.T., Szabo Z., Wong D.F. Nucl Med Biol 2000, 27:627-630.
27. Forsberg M., Lehtonen M., Heikkinen M., Savolainen J., Järvinen T., Männistö P.T. Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. J Pharmacol Exp Ther 2003, 304:498-506.
28. Kaakkola S., Gordin A., Männistö P.T. General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol 1994, 25:813-824.
29. Rice O., Gatley S., Shen J., Huemmer C., Rogoz R., Dejesus O., et al. Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice. Neuropsychopharmacology 2001, 25:679-689.
30. 1 receptor radioligands: implications for imaging studies in schizophrenia. Neuropsychopharmacology 2003, 28:1703-1711.
31. Inoue O., Tsukada H., Yonezawa H., Suhara T., Langstrom B. Reserpine-induced reduction of in vivo binding of SCH 23390 and N-methylspiperone and its reversal by d-amphetamine. Eur J Pharmacol 1991, 197:143-149.
32. 11C]NNC 756. Synapse 1999, 32:93-109.
33. Chou Y.H., Karlsson P., Halldin C., Olsson H., Farde L. A PET study of D(1)-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain. Psychopharmacology 1999, 146:220-227.
34. Olanow C.W., Watkins P.B. Tolcapone: an efficacy and safety review. Clin Neuropharmacol 2007, 30:287-294.