Inactivation of hepatocyte nuclear factor-4α mediates alcohol-induced downregulation of intestinal tight junction proteins

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 3, 2010, Pages

  Zhong, Wei ^a,d   Zhao, Yantao ^a,e   McClain, Craig J ^a,b,c   Kang, Y James ^a,b   Zhou, Zhanxiang ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CHINA AGRICULTURAL UNIVERSITY   (China)

^e AGRICULTURAL UNIVERSITY OF HEBEI   (China)

Author keywords

Claudin 1; Occludin; Oxidative stress; Zinc deprivation; Zonula occludens 1

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PEROXIDASE; SMALL INTERFERING RNA; ZINC; HEPATOCYTE NUCLEAR FACTOR 4; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR GATA 4;

ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL STRAIN CACO 2; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; ILEUM; INTESTINE EPITHELIUM; LONG TERM EXPOSURE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TIGHT JUNCTION; ZINC DEFICIENCY; ANIMAL; CYTOLOGY; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HISTOLOGY; HUMAN; INTESTINE MUCOSA; METABOLISM; RNA INTERFERENCE; TISSUE DISTRIBUTION;

ANIMALS; CACO-2 CELLS; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; ETHANOL; GASTROINTESTINAL TRACT; GATA4 TRANSCRIPTION FACTOR; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; INTESTINAL MUCOSA; MEMBRANE PROTEINS; MICE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIGHT JUNCTIONS; TISSUE DISTRIBUTION; ZINC;

EID: 77957004129     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00515.2009     Document Type: Article

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