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Volumn 37, Issue 7, 2010, Pages 3561-3566

The vacuolar ATPase in bone cells: A potential therapeutic target in osteoporosis

Author keywords

Osteoclast; Osteoporosis; V ATPases; V ATPases inhibitors

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; DIPROPHYLLINE; FR 167356; MESSENGER RNA; PROTEIN INHIBITOR; SB 242784; UNCLASSIFIED DRUG;

EID: 77956977479     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0004-7     Document Type: Review
Times cited : (32)

References (60)
  • 1
    • 67349277071 scopus 로고    scopus 로고
    • Bone cell-matrix protein interactions
    • 1:STN:280:DC%2BD1MzjtFansw%3D%3D 10.1007/s00198-009-0856-7 19340509
    • PJ Marie 2009 Bone cell-matrix protein interactions Osteoporos Int 20 1037 1042 1:STN:280:DC%2BD1MzjtFansw%3D%3D 10.1007/s00198-009-0856-7 19340509
    • (2009) Osteoporos Int , vol.20 , pp. 1037-1042
    • Marie, P.J.1
  • 2
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • 1:STN:280:DC%2BD1M7pvValsg%3D%3D 10.1038/leu.2008.336 19039321
    • GD Roodman 2009 Pathogenesis of myeloma bone disease Leukemia 23 435 441 1:STN:280:DC%2BD1M7pvValsg%3D%3D 10.1038/leu.2008.336 19039321
    • (2009) Leukemia , vol.23 , pp. 435-441
    • Roodman, G.D.1
  • 3
    • 69949148448 scopus 로고    scopus 로고
    • Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
    • 1:CAS:528:DC%2BD1MXhtVKhs7vP 10.1038/nm.2007 19718038
    • B Zhao M Takami A Yamada, et al. 2009 Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis Nat Med 15 1066 1071 1:CAS:528:DC%2BD1MXhtVKhs7vP 10.1038/nm.2007 19718038
    • (2009) Nat Med , vol.15 , pp. 1066-1071
    • Zhao, B.1    Takami, M.2    Yamada, A.3
  • 4
    • 34247872795 scopus 로고    scopus 로고
    • Characterization of vacuolar-ATPase and selective inhibition of vacuolar-H(+)-ATPase in osteoclasts
    • 1:CAS:528:DC%2BD2sXlt1Wqu7o%3D 10.1016/j.bbrc.2007.04.082 17462591
    • G Yao H Feng Y Cai, et al. 2007 Characterization of vacuolar-ATPase and selective inhibition of vacuolar-H(+)-ATPase in osteoclasts Biochem Biophys Res Commun 357 821 827 1:CAS:528:DC%2BD2sXlt1Wqu7o%3D 10.1016/j.bbrc.2007.04.082 17462591
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 821-827
    • Yao, G.1    Feng, H.2    Cai, Y.3
  • 5
    • 48949118346 scopus 로고    scopus 로고
    • Vacuolar H(+)-ATPase
    • 1:CAS:528:DC%2BD1cXovF2jt7o%3D 10.1016/j.biocel.2007.08.006 17897871
    • YT Xiao LX Xiang JZ Shao 2008 Vacuolar H(+)-ATPase Int J Biochem Cell Biol 40 2002 2006 1:CAS:528:DC%2BD1cXovF2jt7o%3D 10.1016/j.biocel.2007.08.006 17897871
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2002-2006
    • Xiao, Y.T.1    Xiang, L.X.2    Shao, J.Z.3
  • 6
    • 0038165450 scopus 로고    scopus 로고
    • The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase- 1 in humans
    • 1:CAS:528:DC%2BD3sXktVaqtbc%3D 10.1074/jbc.M210077200 12649290
    • Y Su A Zhou RS Al-Lamki, et al. 2003 The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans J Biol Chem 278 20013 20018 1:CAS:528:DC%2BD3sXktVaqtbc%3D 10.1074/jbc.M210077200 12649290
    • (2003) J Biol Chem , vol.278 , pp. 20013-20018
    • Su, Y.1    Zhou, A.2    Al-Lamki, R.S.3
  • 7
    • 0033041291 scopus 로고    scopus 로고
    • Decreased bone resorption, osteoclast differentiation, and expression of vacuolar H+-ATPase in antisense DNA-treated mouse metacarpal and calvaria cultures ex vivo
    • 1:CAS:528:DyaK1MXjsVeiurc%3D 10355822
    • T Laitala-Leinonen HK Vaananen 1999 Decreased bone resorption, osteoclast differentiation, and expression of vacuolar H+-ATPase in antisense DNA-treated mouse metacarpal and calvaria cultures ex vivo Antisense Nucleic Acid Drug Dev 9 155 169 1:CAS:528:DyaK1MXjsVeiurc%3D 10355822
    • (1999) Antisense Nucleic Acid Drug Dev , vol.9 , pp. 155-169
    • Laitala-Leinonen, T.1    Vaananen, H.K.2
  • 8
    • 24144443454 scopus 로고    scopus 로고
    • Inhibition of the osteoclast V-ATPase by small interfering RNAs
    • 1:CAS:528:DC%2BD2MXpvV2rurw%3D 10.1016/j.febslet.2005.07.078 16115623
    • Y Hu J Nyman P Muhonen, et al. 2005 Inhibition of the osteoclast V-ATPase by small interfering RNAs FEBS Lett 579 4937 4942 1:CAS:528: DC%2BD2MXpvV2rurw%3D 10.1016/j.febslet.2005.07.078 16115623
    • (2005) FEBS Lett , vol.579 , pp. 4937-4942
    • Hu, Y.1    Nyman, J.2    Muhonen, P.3
  • 9
    • 0037446003 scopus 로고    scopus 로고
    • Effects of bafilomycin A1: An inhibitor of vacuolar H(+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts
    • 1:CAS:528:DC%2BD3sXislOntLg%3D 10.1002/jcb.10477 12647307
    • J Xu HT Feng C Wang, et al. 2003 Effects of bafilomycin A1: an inhibitor of vacuolar H(+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts J Cell Biochem 88 1256 1264 1:CAS:528: DC%2BD3sXislOntLg%3D 10.1002/jcb.10477 12647307
    • (2003) J Cell Biochem , vol.88 , pp. 1256-1264
    • Xu, J.1    Feng, H.T.2    Wang, C.3
  • 10
    • 0032535565 scopus 로고    scopus 로고
    • (2Z, 4E)-5-(5, 6-dichloro-2-indolyl)-2-methoxy-N-(1, 2, 2, 6, 6- pentamethylpiperidin-4-yl)-2, 4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase
    • 1:CAS:528:DyaK1MXltVKlsA%3D%3D 10.1016/S0960-894X(98)00660-X 9934482
    • G Nadler M Morvan I Delimoge, et al. 1998 (2Z, 4E)-5-(5, 6-dichloro-2-indolyl)-2-methoxy-N-(1, 2, 2, 6, 6- pentamethylpiperidin-4-yl)-2, 4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase Bioorg Med Chem Lett 8 3621 3626 1:CAS:528:DyaK1MXltVKlsA%3D%3D 10.1016/S0960-894X(98)00660-X 9934482
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 3621-3626
    • Nadler, G.1    Morvan, M.2    Delimoge, I.3
  • 11
    • 33947513226 scopus 로고    scopus 로고
    • Structure and function of V-ATPases in osteoclasts: Potential therapeutic targets for the treatment of osteolysis
    • 1:CAS:528:DC%2BD2sXnsFKjs7Y%3D 17290355
    • J Xu T Cheng HT Feng, et al. 2007 Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis Histol Histopathol 22 443 454 1:CAS:528:DC%2BD2sXnsFKjs7Y%3D 17290355
    • (2007) Histol Histopathol , vol.22 , pp. 443-454
    • Xu, J.1    Cheng, T.2    Feng, H.T.3
  • 12
    • 0036367733 scopus 로고    scopus 로고
    • Selective inhibition of osteoclast vacuolar H(+)-ATPase
    • 1:CAS:528:DC%2BD38XmvFOjsLc%3D 10.2174/1381612023393369 12171517
    • C Farina S Gagliardi 2002 Selective inhibition of osteoclast vacuolar H(+)-ATPase Curr Pharm Des 8 2033 2048 1:CAS:528:DC%2BD38XmvFOjsLc%3D 10.2174/1381612023393369 12171517
    • (2002) Curr Pharm des , vol.8 , pp. 2033-2048
    • Farina, C.1    Gagliardi, S.2
  • 13
    • 0034641590 scopus 로고    scopus 로고
    • Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis
    • 1:CAS:528:DC%2BD3cXmtVems7s%3D 10.1093/hmg/9.13.2059 10942435
    • U Kornak A Schulz W Friedrich, et al. 2000 Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis Hum Mol Genet 9 2059 2063 1:CAS:528:DC%2BD3cXmtVems7s%3D 10.1093/hmg/9.13.2059 10942435
    • (2000) Hum Mol Genet , vol.9 , pp. 2059-2063
    • Kornak, U.1    Schulz, A.2    Friedrich, W.3
  • 14
    • 46049100082 scopus 로고    scopus 로고
    • Function, structure and regulation of the vacuolar (H+)-ATPases
    • 1:CAS:528:DC%2BD1cXoslCmtb0%3D 10.1016/j.abb.2008.03.025 18406336
    • KC Jefferies DJ Cipriano M Forgac 2008 Function, structure and regulation of the vacuolar (H+)-ATPases Arch Biochem Biophys 476 33 42 1:CAS:528:DC%2BD1cXoslCmtb0%3D 10.1016/j.abb.2008.03.025 18406336
    • (2008) Arch Biochem Biophys , vol.476 , pp. 33-42
    • Jefferies, K.C.1    Cipriano, D.J.2    Forgac, M.3
  • 15
    • 0024461376 scopus 로고
    • Osteoclastic bone resorption by a polarized vacuolar proton pump
    • 1:CAS:528:DyaL1MXlslWlurY%3D 10.1126/science.2528207 2528207
    • HC Blair SL Teitelbaum R Ghiselli, et al. 1989 Osteoclastic bone resorption by a polarized vacuolar proton pump Science 245 855 857 1:CAS:528:DyaL1MXlslWlurY%3D 10.1126/science.2528207 2528207
    • (1989) Science , vol.245 , pp. 855-857
    • Blair, H.C.1    Teitelbaum, S.L.2    Ghiselli, R.3
  • 16
    • 0024990332 scopus 로고
    • Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts
    • 1:CAS:528:DyaK3cXlt12ks7o%3D 10.1083/jcb.111.3.1305 2144003
    • HK Vaananen EK Karhukorpi K Sundquist, et al. 1990 Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts J Cell Biol 111 1305 1311 1:CAS:528:DyaK3cXlt12ks7o%3D 10.1083/jcb.111.3.1305 2144003
    • (1990) J Cell Biol , vol.111 , pp. 1305-1311
    • Vaananen, H.K.1    Karhukorpi, E.K.2    Sundquist, K.3
  • 17
    • 0027401075 scopus 로고
    • Characterization of ATP-dependent proton transport in medullary bone-derived microsomes
    • 1:CAS:528:DyaK3sXksVent74%3D 10.1016/S0169-6009(08)80034-7 8384039
    • K Sundquist 1993 Characterization of ATP-dependent proton transport in medullary bone-derived microsomes Bone Miner 20 17 29 1:CAS:528: DyaK3sXksVent74%3D 10.1016/S0169-6009(08)80034-7 8384039
    • (1993) Bone Miner , vol.20 , pp. 17-29
    • Sundquist, K.1
  • 18
    • 0029670253 scopus 로고    scopus 로고
    • [3H]Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase
    • 10.1016/0005-2736(95)00285-5 8634321
    • JP Mattsson DJ Keeling 1996 [3H]Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase Biochim Biophys Acta 1280 98 106 10.1016/0005-2736(95)00285-5 8634321
    • (1996) Biochim Biophys Acta , vol.1280 , pp. 98-106
    • Mattsson, J.P.1    Keeling, D.J.2
  • 19
    • 0028365620 scopus 로고
    • Cytotoxicity of vacuolar H(+)-ATPase inhibitors to UMR-106 rat osteoblasts: An effect on iron uptake into cells?
    • 1:CAS:528:DyaK2cXls12rs7c%3D 10.1006/cbir.1994.1060 8019493
    • TJ Hall 1994 Cytotoxicity of vacuolar H(+)-ATPase inhibitors to UMR-106 rat osteoblasts: an effect on iron uptake into cells? Cell Biol Int 18 189 193 1:CAS:528:DyaK2cXls12rs7c%3D 10.1006/cbir.1994.1060 8019493
    • (1994) Cell Biol Int , vol.18 , pp. 189-193
    • Hall, T.J.1
  • 20
    • 0036129345 scopus 로고    scopus 로고
    • ATPase pumps in osteoclasts and osteoblasts
    • 1:CAS:528:DC%2BD38XitFWit7k%3D 10.1016/S1357-2725(01)00142-X 11906818
    • MJ Francis RL Lees E Trujillo, et al. 2002 ATPase pumps in osteoclasts and osteoblasts Int J Biochem Cell Biol 34 459 476 1:CAS:528: DC%2BD38XitFWit7k%3D 10.1016/S1357-2725(01)00142-X 11906818
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 459-476
    • Francis, M.J.1    Lees, R.L.2    Trujillo, E.3
  • 21
    • 33646538824 scopus 로고    scopus 로고
    • Structure and regulation of the V-ATPases
    • 1:CAS:528:DC%2BD28XjsV2htro%3D 10.1007/s10863-005-9478-8
    • T Inoue Y Wang K Jefferies, et al. 2005 Structure and regulation of the V-ATPases J Bioenergy Biomembr 37 393 398 1:CAS:528:DC%2BD28XjsV2htro%3D 10.1007/s10863-005-9478-8
    • (2005) J Bioenergy Biomembr , vol.37 , pp. 393-398
    • Inoue, T.1    Wang, Y.2    Jefferies, K.3
  • 22
    • 38349192768 scopus 로고    scopus 로고
    • The vacuolar (H +)-ATPase: Subunit arrangement and in vivo regulation
    • 1:CAS:528:DC%2BD1cXotl2itw%3D%3D 10.1007/s10863-007-9116-8
    • J Qi Y Wang M Forgac 2007 The vacuolar (H +)-ATPase: subunit arrangement and in vivo regulation J Bioenergy Biomembr 39 423 426 1:CAS:528: DC%2BD1cXotl2itw%3D%3D 10.1007/s10863-007-9116-8
    • (2007) J Bioenergy Biomembr , vol.39 , pp. 423-426
    • Qi, J.1    Wang, Y.2    Forgac, M.3
  • 23
    • 33749428456 scopus 로고    scopus 로고
    • The emerging structure of vacuolar ATPases
    • 1:CAS:528:DC%2BD28XhtFKqu7vJ
    • O Drory N Nelson 2006 The emerging structure of vacuolar ATPases Physiology (Bethesda) 21 317 325 1:CAS:528:DC%2BD28XhtFKqu7vJ
    • (2006) Physiology (Bethesda) , vol.21 , pp. 317-325
    • Drory, O.1    Nelson, N.2
  • 24
    • 0036169599 scopus 로고    scopus 로고
    • Novel mutations in the a3 subunit of vacuolar H(+)-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis
    • 1:CAS:528:DC%2BD38Xhtleqs78%3D 10.1016/S8756-3282(01)00684-6 11856654
    • T Michigami T Kageyama K Satomura, et al. 2002 Novel mutations in the a3 subunit of vacuolar H(+)-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis Bone 30 436 439 1:CAS:528:DC%2BD38Xhtleqs78%3D 10.1016/S8756-3282(01)00684-6 11856654
    • (2002) Bone , vol.30 , pp. 436-439
    • Michigami, T.1    Kageyama, T.2    Satomura, K.3
  • 25
    • 33745091487 scopus 로고    scopus 로고
    • Vacuolar ATPase as a drug discovery target
    • 1:CAS:528:DC%2BD28XntFCntL0%3D 10.1358/dnp.2006.19.3.977442 16804565
    • K Niikura 2006 Vacuolar ATPase as a drug discovery target Drug News Perspectives 19 139 144 1:CAS:528:DC%2BD28XntFCntL0%3D 10.1358/dnp.2006.19.3. 977442 16804565
    • (2006) Drug News Perspectives , vol.19 , pp. 139-144
    • Niikura, K.1
  • 26
    • 46349090602 scopus 로고    scopus 로고
    • Structure and regulation of the vacuolar ATPases
    • 1:CAS:528:DC%2BD1cXnsFCnu7k%3D 10.1016/j.bbabio.2008.03.013 18423392
    • DJ Cipriano Y Wang S Bond, et al. 2008 Structure and regulation of the vacuolar ATPases Biochim Biophys Acta 1777 599 604 1:CAS:528: DC%2BD1cXnsFCnu7k%3D 10.1016/j.bbabio.2008.03.013 18423392
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 599-604
    • Cipriano, D.J.1    Wang, Y.2    Bond, S.3
  • 27
    • 7244248726 scopus 로고    scopus 로고
    • TM2 but not TM4 of subunit c′ interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linking
    • 1:CAS:528:DC%2BD2cXosFymt70%3D 10.1074/jbc.M407345200 15322078
    • Y Wang T Inoue M Forgac 2004 TM2 but not TM4 of subunit c′ interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linking J Biol Chem 279 44628 44638 1:CAS:528:DC%2BD2cXosFymt70%3D 10.1074/jbc.M407345200 15322078
    • (2004) J Biol Chem , vol.279 , pp. 44628-44638
    • Wang, Y.1    Inoue, T.2    Forgac, M.3
  • 28
    • 36349017907 scopus 로고    scopus 로고
    • Arrangement of subunits in the proteolipid ring of the V-ATPase
    • 1:CAS:528:DC%2BD2sXhtlSltr%2FE 10.1074/jbc.M704331200 17897940
    • Y Wang DJ Cipriano M Forgac 2007 Arrangement of subunits in the proteolipid ring of the V-ATPase J Biol Chem 282 34058 34065 1:CAS:528:DC%2BD2sXhtlSltr%2FE 10.1074/jbc.M704331200 17897940
    • (2007) J Biol Chem , vol.282 , pp. 34058-34065
    • Wang, Y.1    Cipriano, D.J.2    Forgac, M.3
  • 29
    • 34047268734 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: An essential proton pump component
    • 1:CAS:528:DC%2BD2sXktFOmt70%3D 10.1016/j.gene.2007.01.020 17350184
    • KG Blake-Palmer Y Su AN Smith, et al. 2007 Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component Gene 393 94 100 1:CAS:528:DC%2BD2sXktFOmt70%3D 10.1016/j.gene.2007.01.020 17350184
    • (2007) Gene , vol.393 , pp. 94-100
    • Blake-Palmer, K.G.1    Su, Y.2    Smith, A.N.3
  • 30
    • 0028067756 scopus 로고
    • A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules
    • 1:CAS:528:DyaK2cXmsVOku70%3D 7929063
    • F Supek L Supekova S Mandiyan, et al. 1994 A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules J Biol Chem 269 24102 24106 1:CAS:528:DyaK2cXmsVOku70%3D 7929063
    • (1994) J Biol Chem , vol.269 , pp. 24102-24106
    • Supek, F.1    Supekova, L.2    Mandiyan, S.3
  • 31
    • 0036122004 scopus 로고    scopus 로고
    • Targeted disruption of the mouse gene encoding the V-ATPase accessory subunit Ac45
    • 1:CAS:528:DC%2BD38XjtFKgs74%3D 10.1080/09687680110112910 11989824
    • VT Schoonderwoert GJ Martens 2002 Targeted disruption of the mouse gene encoding the V-ATPase accessory subunit Ac45 Mol Membr Biol 19 67 71 1:CAS:528:DC%2BD38XjtFKgs74%3D 10.1080/09687680110112910 11989824
    • (2002) Mol Membr Biol , vol.19 , pp. 67-71
    • Schoonderwoert, V.T.1    Martens, G.J.2
  • 32
    • 0347157164 scopus 로고    scopus 로고
    • Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)
    • 1:CAS:528:DC%2BD3MXnsVSqtb4%3D 11590366
    • FY Demirci NJ White BW Rigatti, et al. 2001 Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) Mol Vis 7 234 239 1:CAS:528:DC%2BD3MXnsVSqtb4%3D 11590366
    • (2001) Mol Vis , vol.7 , pp. 234-239
    • Demirci, F.Y.1    White, N.J.2    Rigatti, B.W.3
  • 33
    • 34447272956 scopus 로고    scopus 로고
    • Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit
    • 1:CAS:528:DC%2BD2sXosV2nur8%3D 10.1152/ajpcell.00596.2006 17392376
    • N Da Silva WW Shum J El-Annan, et al. 2007 Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit Am J Physiol Cell Physiol 293 C199 C210 1:CAS:528: DC%2BD2sXosV2nur8%3D 10.1152/ajpcell.00596.2006 17392376
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Da Silva, N.1    Shum, W.W.2    El-Annan, J.3
  • 34
    • 58149088485 scopus 로고    scopus 로고
    • Structure of the yeast vacuolar ATPase
    • 1:CAS:528:DC%2BD1cXhsVylsrfF 10.1074/jbc.M805345200 18955482
    • Z Zhang Y Zheng H Mazon, et al. 2008 Structure of the yeast vacuolar ATPase J Biol Chem 283 35983 35995 1:CAS:528:DC%2BD1cXhsVylsrfF 10.1074/jbc.M805345200 18955482
    • (2008) J Biol Chem , vol.283 , pp. 35983-35995
    • Zhang, Z.1    Zheng, Y.2    Mazon, H.3
  • 35
    • 67649438642 scopus 로고    scopus 로고
    • Role of V-ATPases in solid tumors: Importance of the subunit C (Review)
    • 1:CAS:528:DC%2BD1MXmsVCitrg%3D 10.3892/ijo-00000280 19424568
    • M Perez-Sayans A Garcia-Garcia MD Reboiras-Lopez, et al. 2009 Role of V-ATPases in solid tumors: importance of the subunit C (Review) Int J Oncol 34 1513 1520 1:CAS:528:DC%2BD1MXmsVCitrg%3D 10.3892/ijo-00000280 19424568
    • (2009) Int J Oncol , vol.34 , pp. 1513-1520
    • Perez-Sayans, M.1    Garcia-Garcia, A.2    Reboiras-Lopez, M.D.3
  • 36
    • 0029074074 scopus 로고
    • VMA8 encodes a 32-kDa V1 subunit of the Saccharomyces cerevisiae vacuolar H(+)-ATPase required for function and assembly of the enzyme complex
    • 1:CAS:528:DyaK2MXmsFKqsbw%3D 10.1074/jbc.270.25.15037 7797485
    • LA Graham KJ Hill TH Stevens 1995 VMA8 encodes a 32-kDa V1 subunit of the Saccharomyces cerevisiae vacuolar H(+)-ATPase required for function and assembly of the enzyme complex J Biol Chem 270 15037 15044 1:CAS:528: DyaK2MXmsFKqsbw%3D 10.1074/jbc.270.25.15037 7797485
    • (1995) J Biol Chem , vol.270 , pp. 15037-15044
    • Graham, L.A.1    Hill, K.J.2    Stevens, T.H.3
  • 37
    • 0028813472 scopus 로고
    • A bovine cDNA and a yeast gene (VMA8) encoding the subunit D of the vacuolar H(+)-ATPase
    • 1:CAS:528:DyaK2MXjt12qtrY%3D 10.1073/pnas.92.2.497 7831318
    • H Nelson S Mandiyan N Nelson 1995 A bovine cDNA and a yeast gene (VMA8) encoding the subunit D of the vacuolar H(+)-ATPase Proc Natl Acad Sci USA 92 497 501 1:CAS:528:DyaK2MXjt12qtrY%3D 10.1073/pnas.92.2.497 7831318
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 497-501
    • Nelson, H.1    Mandiyan, S.2    Nelson, N.3
  • 38
    • 0023949171 scopus 로고
    • Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase
    • 1:CAS:528:DyaL1MXhvV2n 10.1073/pnas.85.9.3004 2896353
    • S Hirsch A Strauss K Masood, et al. 1988 Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase Proc Natl Acad Sci USA 85 3004 3008 1:CAS:528:DyaL1MXhvV2n 10.1073/pnas.85.9.3004 2896353
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3004-3008
    • Hirsch, S.1    Strauss, A.2    Masood, K.3
  • 39
    • 0036572831 scopus 로고    scopus 로고
    • A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit e
    • 1:CAS:528:DC%2BD38XjvFGhsro%3D 10.1016/S0378-1119(02)00542-5 12036578
    • Y Imai-Senga GH Sun-Wada Y Wada, et al. 2002 A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E Gene 289 7 12 1:CAS:528:DC%2BD38XjvFGhsro%3D 10.1016/S0378-1119(02)00542-5 12036578
    • (2002) Gene , vol.289 , pp. 7-12
    • Imai-Senga, Y.1    Sun-Wada, G.H.2    Wada, Y.3
  • 40
    • 0028031164 scopus 로고
    • A novel 14-kDa V-ATPase subunit in the tobacco hornworm midgut
    • 1:STN:280:DyaK2c7kvVyrtw%3D%3D 8106421
    • R Graf A Lepier WR Harvey, et al. 1994 A novel 14-kDa V-ATPase subunit in the tobacco hornworm midgut J Biol Chem 269 3767 3774 1:STN:280: DyaK2c7kvVyrtw%3D%3D 8106421
    • (1994) J Biol Chem , vol.269 , pp. 3767-3774
    • Graf, R.1    Lepier, A.2    Harvey, W.R.3
  • 41
    • 60149087436 scopus 로고    scopus 로고
    • Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity
    • 1:CAS:528:DC%2BD1MXit1Ojsro%3D 10.1016/j.jmb.2009.01.014 19244615
    • SP Muench M Huss CF Song, et al. 2009 Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity J Mol Biol 386 989 999 1:CAS:528:DC%2BD1MXit1Ojsro%3D 10.1016/j.jmb.2009.01.014 19244615
    • (2009) J Mol Biol , vol.386 , pp. 989-999
    • Muench, S.P.1    Huss, M.2    Song, C.F.3
  • 42
    • 0000729527 scopus 로고    scopus 로고
    • A novel subunit of vacuolar H(+)-ATPase related to the b subunit of F-ATPases
    • 1:CAS:528:DyaK28XjslCrs7w%3D 8786335
    • L Supekova M Sbia F Supek, et al. 1996 A novel subunit of vacuolar H(+)-ATPase related to the b subunit of F-ATPases J Exp Biol 199 1147 1156 1:CAS:528:DyaK28XjslCrs7w%3D 8786335
    • (1996) J Exp Biol , vol.199 , pp. 1147-1156
    • Supekova, L.1    Sbia, M.2    Supek, F.3
  • 43
    • 0035985203 scopus 로고    scopus 로고
    • Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins
    • 1:CAS:528:DC%2BD38XltVWqtrk%3D 10.1091/mbc.02-02-0026 12058068
    • M Geyer OT Fackler BM Peterlin 2002 Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins Mol Biol Cell 13 2045 2056 1:CAS:528:DC%2BD38XltVWqtrk%3D 10.1091/mbc.02-02-0026 12058068
    • (2002) Mol Biol Cell , vol.13 , pp. 2045-2056
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 44
    • 0024327043 scopus 로고
    • Molecular mechanisms of bone resorption by the osteoclast
    • 1:CAS:528:DyaL1MXltFamt7k%3D 10.1002/ar.1092240220 2549811
    • R Baron 1989 Molecular mechanisms of bone resorption by the osteoclast Anat Rec 224 317 324 1:CAS:528:DyaL1MXltFamt7k%3D 10.1002/ar.1092240220 2549811
    • (1989) Anat Rec , vol.224 , pp. 317-324
    • Baron, R.1
  • 45
    • 0022348139 scopus 로고
    • Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border
    • 1:CAS:528:DyaL28Xjt1ahuw%3D%3D 10.1083/jcb.101.6.2210 3905822
    • R Baron L Neff D Louvard, et al. 1985 Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border J Cell Biol 101 2210 2222 1:CAS:528:DyaL28Xjt1ahuw%3D%3D 10.1083/jcb.101.6.2210 3905822
    • (1985) J Cell Biol , vol.101 , pp. 2210-2222
    • Baron, R.1    Neff, L.2    Louvard, D.3
  • 46
    • 58249089414 scopus 로고    scopus 로고
    • Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts
    • 1:CAS:528:DC%2BD1cXhsV2lt7zL 10.1042/BJ20081073 18657050
    • S Feng L Deng W Chen, et al. 2009 Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts Biochem J 417 195 203 1:CAS:528:DC%2BD1cXhsV2lt7zL 10.1042/BJ20081073 18657050
    • (2009) Biochem J , vol.417 , pp. 195-203
    • Feng, S.1    Deng, L.2    Chen, W.3
  • 47
    • 0032739536 scopus 로고    scopus 로고
    • Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro
    • 1:CAS:528:DyaK1MXns1Olsb4%3D 10523502
    • T Laitala-Leinonen C Lowik S Papapoulos, et al. 1999 Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro J Cell Sci 112 Pt 21 3657 3666 1:CAS:528:DyaK1MXns1Olsb4%3D 10523502
    • (1999) J Cell Sci , vol.112 , Issue.PART 21 , pp. 3657-3666
    • Laitala-Leinonen, T.1    Lowik, C.2    Papapoulos, S.3
  • 48
    • 0030041317 scopus 로고    scopus 로고
    • Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes
    • 1:CAS:528:DyaK28XhtVygu7c%3D 8772466
    • BS Lee LS Holliday B Ojikutu, et al. 1996 Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes Am J Physiol 270 C382 C388 1:CAS:528:DyaK28XhtVygu7c%3D 8772466
    • (1996) Am J Physiol , vol.270
    • Lee, B.S.1    Holliday, L.S.2    Ojikutu, B.3
  • 49
    • 0031006179 scopus 로고    scopus 로고
    • Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies
    • 1:CAS:528:DyaK2sXjtlOqtrg%3D 10.1359/jbmr.1997.12.5.753 9144341
    • JP Mattsson C Skyman H Palokangas, et al. 1997 Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies J Bone Miner Res 12 753 760 1:CAS:528:DyaK2sXjtlOqtrg%3D 10.1359/jbmr.1997.12.5.753 9144341
    • (1997) J Bone Miner Res , vol.12 , pp. 753-760
    • Mattsson, J.P.1    Skyman, C.2    Palokangas, H.3
  • 50
    • 10744233422 scopus 로고    scopus 로고
    • Vacuolar H+-ATPase binding to microfilaments: Regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B
    • 1:CAS:528:DC%2BD2cXhsFejtLo%3D 10.1074/jbc.M305351200 14662773
    • SH Chen MR Bubb EG Yarmola, et al. 2004 Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B J Biol Chem 279 7988 7998 1:CAS:528:DC%2BD2cXhsFejtLo%3D 10.1074/jbc.M305351200 14662773
    • (2004) J Biol Chem , vol.279 , pp. 7988-7998
    • Chen, S.H.1    Bubb, M.R.2    Yarmola, E.G.3
  • 51
    • 0034644703 scopus 로고    scopus 로고
    • The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site
    • 1:STN:280:DC%2BD3M%2FislClsg%3D%3D 10.1074/jbc.M004795200 10915794
    • LS Holliday M Lu BS Lee, et al. 2000 The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site J Biol Chem 275 32331 32337 1:STN:280:DC%2BD3M%2FislClsg%3D%3D 10.1074/jbc.M004795200 10915794
    • (2000) J Biol Chem , vol.275 , pp. 32331-32337
    • Holliday, L.S.1    Lu, M.2    Lee, B.S.3
  • 52
    • 33748168693 scopus 로고    scopus 로고
    • Coordination of microtubules and the actin cytoskeleton is important in osteoclast function, but calcitonin disrupts sealing zones without affecting microtubule networks
    • 1:CAS:528:DC%2BD28XpsVOhtrg%3D 10.1016/j.bone.2006.04.010 16774853
    • S Okumura T Mizoguchi N Sato, et al. 2006 Coordination of microtubules and the actin cytoskeleton is important in osteoclast function, but calcitonin disrupts sealing zones without affecting microtubule networks Bone 39 684 693 1:CAS:528:DC%2BD28XpsVOhtrg%3D 10.1016/j.bone.2006.04.010 16774853
    • (2006) Bone , vol.39 , pp. 684-693
    • Okumura, S.1    Mizoguchi, T.2    Sato, N.3
  • 53
    • 0032748995 scopus 로고    scopus 로고
    • Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
    • 1:CAS:528:DyaK1MXnvFOktbc%3D 10.1038/70563 10581033
    • YP Li W Chen Y Liang, et al. 1999 Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification Nat Genet 23 447 451 1:CAS:528:DyaK1MXnvFOktbc%3D 10.1038/70563 10581033
    • (1999) Nat Genet , vol.23 , pp. 447-451
    • Li, Y.P.1    Chen, W.2    Liang, Y.3
  • 54
    • 1542677106 scopus 로고    scopus 로고
    • The a3 isoform of the 100-kDa V-ATPase subunit is highly but differentially expressed in large (> or = 10 nuclei) and small (< or = nuclei) osteoclasts
    • 1:CAS:528:DC%2BD3sXptlGrsb0%3D 10.1074/jbc.M309914200 14504271
    • MF Manolson H Yu W Chen, et al. 2003 The a3 isoform of the 100-kDa V-ATPase subunit is highly but differentially expressed in large (> or = 10 nuclei) and small (< or = nuclei) osteoclasts J Biol Chem 278 49271 49278 1:CAS:528:DC%2BD3sXptlGrsb0%3D 10.1074/jbc.M309914200 14504271
    • (2003) J Biol Chem , vol.278 , pp. 49271-49278
    • Manolson, M.F.1    Yu, H.2    Chen, W.3
  • 55
    • 0035880417 scopus 로고    scopus 로고
    • The mutational spectrum of human malignant autosomal recessive osteopetrosis
    • 1:CAS:528:DC%2BD3MXntFCitLY%3D 10.1093/hmg/10.17.1767 11532986
    • C Sobacchi A Frattini P Orchard, et al. 2001 The mutational spectrum of human malignant autosomal recessive osteopetrosis Hum Mol Genet 10 1767 1773 1:CAS:528:DC%2BD3MXntFCitLY%3D 10.1093/hmg/10.17.1767 11532986
    • (2001) Hum Mol Genet , vol.10 , pp. 1767-1773
    • Sobacchi, C.1    Frattini, A.2    Orchard, P.3
  • 56
    • 23944509836 scopus 로고    scopus 로고
    • Vacuolar H+-ATPase d2 subunit: Molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone
    • 1:CAS:528:DC%2BD2MXksF2gs7g%3D 10.1681/ASN.2004090761 15800125
    • AN Smith F Jouret S Bord, et al. 2005 Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone J Am Soc Nephrol 16 1245 1256 1:CAS:528:DC%2BD2MXksF2gs7g%3D 10.1681/ASN.2004090761 15800125
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1245-1256
    • Smith, A.N.1    Jouret, F.2    Bord, S.3
  • 57
    • 0033941575 scopus 로고    scopus 로고
    • A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats
    • 1:CAS:528:DC%2BD3cXkvFWgs7o%3D 10.1172/JCI6145 10903347
    • L Visentin RA Dodds M Valente, et al. 2000 A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats J Clin Invest 106 309 318 1:CAS:528:DC%2BD3cXkvFWgs7o%3D 10.1172/JCI6145 10903347
    • (2000) J Clin Invest , vol.106 , pp. 309-318
    • Visentin, L.1    Dodds, R.A.2    Valente, M.3
  • 58
    • 0025317797 scopus 로고
    • Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption
    • 1:CAS:528:DyaK3cXitlarsbc%3D 10.1016/0006-291X(90)91709-2 2139331
    • K Sundquist P Lakkakorpi B Wallmark, et al. 1990 Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption Biochem Biophys Res Commun 168 309 313 1:CAS:528:DyaK3cXitlarsbc%3D 10.1016/0006-291X(90)91709-2 2139331
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 309-313
    • Sundquist, K.1    Lakkakorpi, P.2    Wallmark, B.3
  • 59
    • 24144489983 scopus 로고    scopus 로고
    • A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: Potential for clinical application
    • 1:CAS:528:DC%2BD2MXhtVOltrvI 10.1359/JBMR.050517 16059630
    • K Niikura N Takeshita M Takano 2005 A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application J Bone Miner Res 20 1579 1588 1:CAS:528:DC%2BD2MXhtVOltrvI 10.1359/JBMR.050517 16059630
    • (2005) J Bone Miner Res , vol.20 , pp. 1579-1588
    • Niikura, K.1    Takeshita, N.2    Takano, M.3
  • 60
    • 38449105080 scopus 로고    scopus 로고
    • Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption
    • 10.1359/jbmr.070613 17576165
    • MG Sorensen K Henriksen AV Neutzsky-Wulff, et al. 2007 Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption J Bone Miner Res 22 1640 1648 10.1359/jbmr.070613 17576165
    • (2007) J Bone Miner Res , vol.22 , pp. 1640-1648
    • Sorensen, M.G.1    Henriksen, K.2    Neutzsky-Wulff, A.V.3


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