Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N 2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [13C2]-VC

Chemical Research in Toxicology

Volumn 23, Issue 9, 2010, Pages 1485-1491

  Mutlu, Esra ^a   Collins, Leonard B ^a   Stout, Matthew D ^a,c   Upton, Patricia B ^a   Daye, Laura R ^a   Winsett, Darrell ^b   Hatch, Gary ^b   Evansky, Paul ^a   Swenberg, James A ^a  

^a IL   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; DNA; GUANINE DERIVATIVE; ISOTOPE; N 2,3 ETHENOGUANINE; UNCLASSIFIED DRUG; VINYL CHLORIDE;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KIDNEY; LIQUID CHROMATOGRAPHY; LUNG; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; CARBON ISOTOPES; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; GUANINE; HALF-LIFE; KIDNEY; LIVER; LUNG; MALE; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; VINYL CHLORIDE;

ANIMALIA; RATTUS;

EID: 77956942037     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx1001767     Document Type: Article

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