The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α

Medical Oncology

Volumn 27, Issue 3, 2010, Pages 697-701

  Xia, De Hong ^a   Xi, Lei ^a   Xv, Chen ^a   Mao, Wei Dong ^a   Shen, Wei Sheng ^a   Shu, Zhong Qin ^a   Yang, Hong Zhi ^b   Dai, Min ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Ambroxol; Cytokine; Pulmonary injury; Radiation prevention; Radiotherapy

Indexed keywords

AMBROXOL; CARBON MONOXIDE; CYTOKINE; GLUCOCORTICOID; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; IMMUNE RESPONSE; LUNG CANCER; LUNG FUNCTION; LUNG INJURY; MAJOR CLINICAL STUDY; MALE; PLASMA; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PNEUMONIA; RANDOMIZED CONTROLLED TRIAL;

ADRENAL CORTEX HORMONES; ADULT; AGED; AMBROXOL; CARBON MONOXIDE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PULMONARY DIFFUSING CAPACITY; PULMONARY FIBROSIS; RADIATION PNEUMONITIS; RADIOTHERAPY, CONFORMAL; SINGLE-BLIND METHOD; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956933267     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-009-9271-3     Document Type: Article

References (9)

1. DM Brass GW Hoyle HG Poovey JY Liu AR Brody 1999 Reduced tumor necrosis factor-alpha and transforming growth factor-beta 1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure Am J Pathol 154 853 862 1:CAS:528:DyaK1MXitVeltbY%3D 10079263
2. CE Rube D Uthe F Wilfert D Ludwing K Ying J Konig J Palm A Schuck N Willich K Remberger, et al. 2005 The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation Int J Radiat Oncol Biol Phys 61 1482 1492 15817354
3. CE Rube D Uthe KW Schmid KD Richter J Wessel A Schuck N Willich C Rube 2000 Dose dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation Int J Radiat Oncol Biol Phys 47 1033 1042 1:CAS:528:DC%2BD3cXktFSisbk%3D 10863076
4. CE Rube F Wilfert D Uthe KW Schmid R Knoop N Willich A Schuck 2002 Rube C: modulation of radiation-induced tumor necrosis factor α (TNF-α) expression in the lung tissue by penloxifylline Radiother Oncol 64 177 187 10.1016/S0167-8140(02)00077-4 1:CAS:528:DC%2BD38XntVWrsLc%3D 12242128 (Pubitemid 35247896)
5. D Aztonadou N Coliarakis M Synodinou H Athanassiou A Kouveli C Verigos G Georgakopouls K Panoussaki P Karageorgis N Throuvalas 2001 Randomized phase III trial of radiation treatment ± Amifostil in patients with advanced-stage lung cancer Int J Radiat Oncol Biol Phys 51 915 922
6. A Cillissen 1998 Nowak D: characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy Respir Med 92 609 623 10.1016/S0954-6111(98) 90506-6 (Pubitemid 28174829)
7. X Su L Wang Y Song 2004 Bai C: inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide Intensive Care Med 30 133 140 10.1007/s00134-003-2001-y 14504727 (Pubitemid 38147119)
8. W Qiao Y Zhao C Wang R Wang 2006 Experimental study of the protective effect of ambroxol on radiation-induced pulmonary injury Chin J Radiol Med Prot 26 137 140 1:CAS:528:DC%2BD2sXpsV2gsrw%3D (in Chinese)
9. X Zhou G Zhu G Zhang B Sun 2003 Experimental research on the effect of ambroxol on acute lung injury Chin J Tuberc Respir Dis 26 440 441 (in Chinese)