Modulation of radiation-induced tumour necrosis factor α (TNF-α) expression in the lung tissue by pentoxifylline

Radiotherapy and Oncology

Volumn 64, Issue 2, 2002, Pages 177-187

  Rübe, Claudia E ^a   Wilfert, Falk ^a   Uthe, Daniela ^b   Schmid, Kurt W ^c   Knoop, Reinhild ^b   Willich, Norman ^b   Schuck, Andreas ^b   Rübe, Christian ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Fibrosis; Ionising radiation; Pentoxifylline; Pneumonitis; TNF

Indexed keywords

ALKALINE PHOSPHATASE; MESSENGER RNA; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG EFFECT; EXPERIMENTAL MODEL; FEMALE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATORY CELL; LATENT PERIOD; LUNG INJURY; LUNG PARENCHYMA; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PNEUMONIA; RADIATION RESPONSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORAX; TISSUE LEVEL;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MICE, INBRED C57BL; PENTOXIFYLLINE; POLYMERASE CHAIN REACTION; RADIATION-PROTECTIVE AGENTS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036669350     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(02)00077-4     Document Type: Article

References (46)

1. Ardizzoia A., Lissoni P., Tancini G., et al. Respiratory distress syndrome in patients with advanced cancer treated with pentoxifylline: a randomized study. Support Care Cancer. 1:1993;331-333.
2. Balibrea J.L., Arias-Diaz J., Garcia C., et al. Effect of pentoxifylline and somatostatin on tumour necrosis factor production by human pulmonary macrophages. Circ Shock. 43:1994;51-56.
3. Beck-Schimmer B., Schimmer R.C., Warner R.L., et al. Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol. 17:1997;344-352.
4. Brass D.M., Hoyle G.W., Poovey H.G., et al. Reduced tumor necrosis factor-alpha and transforming growth factor-beta 1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure. Am J Pathol. 154:1999;853-862.
5. Cordell J.L., Falini B., Erber W.N., et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 32:1984;219-229.
6. Delanian S., Balla-Mekias S., Lefaix J.L. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol. 17:1999;3283-3290.
7. Delanian S. Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol. Br J Radiol. 71:1998;892-894.
8. Doherty G.M., Jensen J.C., Alexander H.R., et al. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery. 110:1991;192-198.
9. Entzian P., Gerlach C., Gerdes J., et al. Pentoxifyline inhibits experimental bleomycin-induced fibrosing alveolitis. Pneumologie. 51:1997;375-380.
10. Entzian P., Zahringer U., Schlaak M., et al. Comparative study on effects of pentoxifylline, prednisolone and colchicine in experimental alveolitis. Int J Immunopharmacol. 20:1998;723-735.
11. Finkelstein J.N., Johnston C.J., Baggs R., et al. Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys. 28:1994;621-631.
12. Franko A.J., Sharplin J., Ghahary A., et al. Immunohistochemical localization of transforming growth factor β and tumor necrosis factor α in the lungs of fibrosis-prone and 'non-fibrosing' mice during the latent period and early phase after irradiation. Radiat Res. 147:1997;245-256.
13. Futran N.D., Trotti A., Gwede C. Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. Laryngoscope. 107:1997;391-395.
14. Gottlober P., Krahn G., Korting H.C., et al. The treatment of cutaneous radiation-induced fibrosis with pentoxifylline and vitamin E. Strahlenther Onkol. 172:1996;34-38.
15. Harada H., Ishizaka A., Yonemaru M., et al. The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis. Am Rev Respir Dis. 140:1989;974-980.
16. Heid C.A., Stevens J., Livak K.J., et al. Real time quantitative PCR. Genome Methods. 6:1996;986-994.
17. Honess D.J., Dennis I.F., Bleehen N.M. Pentoxifylline: its pharmakokinetics and ability to improve tumour perfusion and radiosensitivity in mice. Radiother Oncol. 28:1993;208-218.
18. Hong J.-H., Chiang C.-S., Campbell I.L., et al. Induction of acute phase gene expression by brain irradiation. Int J Radiat Oncol Biol Phys. 33:1995;619-626.
19. Ibelgaufts H. TNF-a: tumor necrosis factor alpha. Dictionary of cytokines. 1995;VCH Verlagsgesellschaft mbH, Weinheim. p. 709-17.
20. Jetten A.M. Growth and differentiation factors in tracheobronchial epithelium. Am J Physiol. 260:1991;L361-L373.
21. Johnston C.J., Piedboeuf B., Baggs R., et al. Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res. 142:1995;197-203.
22. Johnston C.J., Piedboeuf B., Rubin F., et al. Early and persistant alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 145:1996;762-767.
23. Kallfass E., Krämling H.J., Schultz-Hector S. Early inflammatory reaction of the rabbit coeliac artery wall after combined intraoperative (IORT) and external (ERT) irradiation. Radiother Oncol. 39:1996;167-178.
24. Kim S.H., Khil M.S., Ryu S., et al. Enhancement of radiation response on human carcinoma cells in culture by pentoxifylline. Int J Radiat Oncol Biol Phys. 25:1993;61-65.
25. Kwon H.-C., Kim S.-K., Chung W.-K., et al. Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomized multicenter trial. Radiother Oncol. 56:2000;175-179.
26. Lee I., Levitt S.H., Song C.W. Improved tumour oxygenation and radiosensitization by combination with nicotinamide and pentoxifylline. Int J Radiat Biol. 64:1993;237-244.
27. Lilly C.M., Sandhu J.S., Ishizaka A., et al. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis. 139:1989;1361-1368.
28. Lissoni F., Ardizzoia A., Perego M.S., et al. Inhibition of tumor necrosis factor-alpha secretion by pentoxifylline in advanced cancer patients with abnormally high blood levels of tumor necrosis factor-alpha. J Biol Regul Homeost Agents. 7:1993;73-75.
29. Litwin M.S., Gamble J.R., Vadas M.A. Role of cytokines in endothelial cell function. Aggarwal B.B., Pun R.K., Human cytokines: their role in disease and therapy. 1995;101-129 Blackwell Science, Oxford, England.
30. McDonald S., Rubin P., Phillips T.L., et al. Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems. Int J Radiat Oncol Biol Phys. 31:1995;1187-1203.
31. Molteni A., Moulder J.E., Cohen E.F., et al. Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int J Radiat Biol. 76:2000;523-532.
32. Movsas B., Raffin T.A., Epstein A.H., et al. Pulmonary radiation injury. Chest. 111:1997;1061-1076.
33. Overbergh L., Valckx D., Waer M., et al. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine. 11:1999;305-312.
34. Rodemann H.P., Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother Oncol. 35:1995;83-90.
35. Rubin P., Johnston C.J., Williams J.P., et al. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 33:1995;99-109.
36. Rübe C., Finke C., van Valen F., et al. Ionizing radiation induces production of tumor necrosis factor α in the Ewing's sarcoma cell line RM 82 in vitro and in vivo. Strahlenther Onkol. 173:1997;407-414.
37. Rübe C.E., Uthe D., Schmid K.W., et al. Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys. 47:2000;1033-1042.
38. Samlaska C.P., Winfield E.A. Pentoxifylline. J Am Acad Dermatol. 30:1994;603-621.
39. Siebert P.D., Larrick J.W. PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR. Biotechniques. 14:1993;244-249.
40. Travis E.L., Komaki R. Treatment-related lung damage. Pass H.I., Mitchell J.B., Johnson D.H., et al. Lung cancer: principles and practice. 1996;285-301 Lippincott-Raven Publishers, Philadelphia, PA.
41. Vernimmen F., Verheye-Dua F., du-Toit H., et al. Effect of pentoxifylline on radiation damage and tumor growth. Strahlenther Onkol. 170:1994;595-601.
42. Yi E.S., Bedoya A., Lee H., et al. Radiation-induced lung injury in vivo: expression of transforming growth factor-beta precedes fibrosis. Inflammation. 20:1996;339-351.
43. Zabel P., Entzian F., Dalhoff K., et al. Pentoxifylline in treatment of sarcoidosis. Am J Respir Crit Care Med. 155:1997;1665-1669.
44. Zabel P., Schade F.U., Schlaak M. Inhibition of endogenous TNF formation by pentoxifylline. Immunobiology. 187:1993;447-463.
45. Zabel P., Schade F.U., Schlaak M. Pentoxifylline - an inhibitor of the synthesis of tumor necrosis factor alpha. Immun Infekt. 20:1992;80-83.
46. Zhang Y., Pasparakis M., Kollias G., et al. Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Biol Chem. 274:1999;14786-14790.