CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes

Journal of Immunology

Volumn 185, Issue 4, 2010, Pages 2059-2070

  Lai, Jacqueline C Y ^a,b   Wlodarska, Marta ^a   Liu, David J ^a,c   Abraham, Ninan ^a   Johnson, Pauline ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR9; STEM CELL ANTIGEN 1; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; CXCL12 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PTPRC PROTEIN, MOUSE; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CD4- CD8- T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DOUBLE NEGATIVE 1 CELL; IN VIVO STUDY; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; THYMUS; ADOPTIVE TRANSFER; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; COCULTURE; CYTOLOGY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MOUSE MUTANT; STROMA CELL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD45; BONE MARROW CELLS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CXCL12; COCULTURE TECHNIQUES; FEMALE; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, ANTIGEN, T-CELL; STROMAL CELLS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 77956930241     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902693     Document Type: Article

References (44)

1. Bhandoola, A., H. von Boehmer, H. T. Petrie, and J. C. Zúñiga-Pflücker. 2007. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26: 678-689.
2. Kondo, M., I. L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661-672. (Pubitemid 27513657)
3. Uehara, S., A. Grinberg, J. M. Farber, and P. E. Love. 2002. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168: 2811-2819.
4. Lind, E. F., S. E. Prockop, H. E. Porritt, and H. T. Petrie. 2001. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194: 127-134.
5. Petrie, H. T., and J. C. Zúñiga-Pflücker. 2007. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 25: 649-679.
6. Petrie, H. T. 2003. Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3: 859-866.
7. Schmitt, T. M., M. Ciofani, H. T. Petrie, and J. C. Zúñiga- Pflücker. 2004. Maintenance of T cell specification and differentiation requires recurrent Notch receptor-ligand interactions. J. Exp. Med. 200: 469-479.
8. Garbe, A. I., and H. von Boehmer. 2007. TCR and Notch synergize in alphabeta versus gammadelta lineage choice. Trends Immunol. 28: 124-131.
9. García-Peydró, M., V. G. de Yébenes, and M. L. Toribio. 2006. Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J. Immunol. 177: 3711-3720.
10. Massa, S., G. Balciunaite, R. Ceredig, and A. G. Rolink. 2006. Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro. Eur. J. Immunol. 36: 526-532.
11. Huang, J., K. P. Garrett, R. Pelayo, J. C. Zúñiga- Pflücker, H. T. Petrie, and P. W. Kincade. 2005. Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J. Immunol. 175: 4858-4865.
12. Matsuzaki, Y., J. Gyotoku, M. Ogawa, S. Nishikawa, Y. Katsura, G. Gachelin, and H. Nakauchi. 1993. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. J. Exp. Med. 178: 1283-1292.
13. Porritt, H. E., L. L. Rumfelt, S. Tabrizifard, T. M. Schmitt, J. C. Zúñiga-Pflücker, and H. T. Petrie. 2004. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20: 735-745.
14. Plotkin, J., S. E. Prockop, A. Lepique, and H. T. Petrie. 2003. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J. Immunol. 171: 4521-4527.
15. Misslitz, A., O. Pabst, G. Hintzen, L. Ohl, E. Kremmer, H. T. Petrie, and R. Förster. 2004. Thymic T cell development and progenitor localization depend on CCR7. J. Exp. Med. 200: 481-491.
16. Hermiston, M. L., Z. Xu, and A. Weiss. 2003. CD45: a critical regulator of signaling thresholds in immune cells. Annu. Rev. Immunol. 21: 107-137.
17. Byth, K. F., L. A. Conroy, S. Howlett, A. J. H. Smith, J. May, D. R. Alexander, and N. Holmes. 1996. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J. Exp. Med. 183: 1707-1718.
18. Kishihara, K., J. Penninger, V. A. Wallace, T. M. Kündig, K. Kawai, A. Wakeham, E. Timms, K. Pfeffer, P. S. Ohashi, M. L. Thomas, et al. 1993. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74: 143-156.
19. Fernandis, A. Z., R. P. Cherla, and R. K. Ganju. 2003. Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase, CD45. J. Biol. Chem. 278: 9536-9543.
20. Irie-Sasaki, J., T. Sasaki, W. Matsumoto, A. Opavsky, M. Cheng, G. Welstead, E. Griffiths, C. Krawczyk, C. D. Richardson, K. Aitken, et al. 2001. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409: 349-354.
21. Wright, D. E., S. H. Cheshier, A. J. Wagers, T. D. Randall, J. L. Christensen, and I. L. Weissman. 2001. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 97: 2278-2285.
22. Schmitt, T. M., and J. C. Zúñiga-Pflücker. 2002. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17: 749-756.
23. Dudley, E. C., H. T. Petrie, L. M. Shah, M. J. Owen, and A. C. Hayday. 1994. T cell receptor b chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1: 83-93.
24. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4: 168-174.
25. Bhandoola, A., and A. Sambandam. 2006. From stem cell to T cell: one route or many? Nat. Rev. Immunol. 6: 117-126.
26. Gossens, K., S. Naus, S. Y. Corbel, S. Lin, F. M. Rossi, J. Kast, and H. J. Ziltener. 2009. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J. Exp. Med. 206: 761-778.
27. Shortman, K., M. Egerton, G. J. Spangrude, and R. Scollay. 1990. The generation and fate of thymocytes. Semin. Immunol. 2: 3-12.
28. Ogilvy, S., C. Louis-Dit-Sully, J. Cooper, R. L. Cassady, D. R. Alexander, and N. Holmes. 2003. Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice. J. Immunol. 171: 1792-1800.
29. Rothenberg, E. V., J. E. Moore, and M. A. Yui. 2008. Launching the T-cell-lineage developmental programme. Nat. Rev. Immunol. 8: 9-21.
30. Schwarz, B. A., and A. Bhandoola. 2004. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5: 953-960.
31. + T cells in CD45-deficient mice. J. Immunol. 166: 6066-6073.
32. Egawa, T., G. Eberl, I. Taniuchi, K. Benlagha, F. Geissmann, L. Hennighausen, A. Bendelac, and D. R. Littman. 2005. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22: 705-716.
33. Ciofani, M., G. C. Knowles, D. L. Wiest, H. von Boehmer, and J. C. Zúñiga-Pflücker. 2006. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity 25: 105-116.
34. lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J. Exp. Med. 181: 345-349.
35. Tanigaki, K., and T. Honjo. 2007. Regulation of lymphocyte development by Notch signaling. Nat. Immunol. 8: 451-456.
36. -/- mice. J. Immunol. 157: 2366-2373.
37. Fleming, H. E., C. D. Milne, and C. J. Paige. 2004. CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro. J. Immunol. 173: 2542-2551.
38. Mee, P. J., M. Turner, M. A. Basson, P. S. Costello, R. Zamoyska, and V. L. Tybulewicz. 1999. Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur. J. Immunol. 29: 2923-2933.
39. Ferguson, B. V., and H. L. Ostergaard. 2010. CD45 regulates thymocyte survival during development in fetal thymic organ culture. Immunobiology 215: 458-465.
40. Ciofani, M., and J. C. Zúñiga-Pflücker. 2005. Notch promotes survival of pre- T cells at the β-selection checkpoint by regulating cellular metabolism. Nat. Immunol. 6: 881-888.
41. lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem. 279: 2937-2944.
42. Balciunaite, G., R. Ceredig, H. J. Fehling, J. C. Zúñiga- Pflücker, and A. G. Rolink. 2005. The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur. J. Immunol. 35: 1292-1300.
43. Shivtiel, S., O. Kollet, K. Lapid, A. Schajnovitz, P. Goichberg, A. Kalinkovich, E. Shezen, M. Tesio, N. Netzer, I. Petit, et al. 2008. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. J. Exp. Med. 205: 2381-2395.
44. Δ/Δ mutant thymus. J. Immunol. 180: 914-921.