How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality

Statistics in Medicine

Volumn 29, Issue 22, 2010, Pages 2347-2358

  Finner, Helmut ^a   Strassburger, Klaus ^a   Heid, Iris M ^b,d   Herder, Christian ^a   Rathmann, Wolfgang ^a   Giani, Guido ^a   Dickhaus, Thorsten ^c   Lichtner, Peter ^d,e   Meitinger, Thomas ^d,e   Wichmann, H Erich ^d,f   Illig, Thomas ^d   Gieger, Christian ^d  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

False discovery rate; Genome wide association (GWA) studies; Genotyping errors; Multiple comparisons; Multiple hypotheses testing; Quality control; Randomized p values

Indexed keywords

ADULT; AGED; ALGORITHM; ARTICLE; GENE FREQUENCY; GENETIC ANALYSIS; GENOTYPE; GERMANY; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; PROBABILITY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BAYES THEOREM; CARDIOVASCULAR DISEASES; DATA INTERPRETATION, STATISTICAL; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GERMANY; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77956928025     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.4004     Document Type: Article

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