Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina

Neurobiology of Aging

Volumn 31, Issue 11, 2010, Pages 2002-2010

  Wang, Ai Ling ^a   Lukas, Thomas J ^a   Yuan, Ming ^a   Neufeld, Arthur H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

8 OHdG; Base excision repair enzymes; Oxidative damage; Retina

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CELL NUCLEUS DNA; DNA GLYCOSYLASE MUTY; ENDONUCLEASE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SUPEROXIDE DISMUTASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL DNA DISORDER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; RETINA NEUROEPITHELIAL LAYER; WESTERN BLOTTING;

AGING; ANIMALS; DEOXYGUANOSINE; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA REPAIR ENZYMES; DNA, MITOCHONDRIAL; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; NEURONS; PHOTORECEPTOR CELLS, VERTEBRATE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED BN; RETINA; RETINAL GANGLION CELLS; SUPEROXIDE DISMUTASE;

EID: 77956926306     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.10.019     Document Type: Article

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