Characterization of the extrinsic apoptotic pathway in the basal chordate amphioxus

Science Signaling

Volumn 3, Issue 139, 2010, Pages

  Yuan, Shaochun ^a   Liu, Huiling ^a   Gu, Ming ^a   Xu, Liqun ^a   Huang, Shengfeng ^a   Ren, Zhenhua ^a   Xu, Anlong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CRADD PROTEIN; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN;

APOPTOSIS; ARTICLE; BRANCHIOSTOMA BELCHERI TSINGTAUENSE; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; FILAMENTOUS ALGA; GENE ACTIVATION; GENETIC ANALYSIS; GENOME ANALYSIS; HUMAN; HUMAN CELL; INVERTEBRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VERTEBRATE; ANIMAL; CELL STRAIN HEK293; GENETICS; HELA CELL; INVERTEBRATE CHORDATA; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

BRANCHIOSTOMA BELCHERI; BRANCHIOSTOMA LANCEOLATUM; ECHINOIDEA; INVERTEBRATA; VERTEBRATA;

ANIMALS; APOPTOSIS; CASPASE 8; CHORDATA, NONVERTEBRATE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HEK293 CELLS; HELA CELLS; HUMANS; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 77956919856     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000906     Document Type: Article

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42. Acknowledgments: We thank H. Tang for constructive comments on this study. Funding: This work was supported by project 2007CB815800 of the National Basic Research Program (973); project 2008AA092603 of the State High-Tech Development Project (863); project 2007DFA30840 of the International S&T Cooperation Program from the Ministry of Science and Technology of China; key project (0107) from the Ministry of Education; the second special supporting project 200902341 of the China Postdoctoral Science Foundation; and project 30901305 of the National Nature Science Foundation of China. A.X. is a recipient of the Outstanding Young Scientist Award from the National Nature Science Foundation of China. Author contributions: S.Y. designed and performed most of the experiments and co-wrote the paper. H.L. constructed most of the vectors and performed the reporter assays. M.G. performed the subcellular analysis. L.X. cloned BbtCaspase-8. S.H. did the sequence analysis. Z.R. prepared the cells used in this study. A.X. conceived and co-designed the study, advised on experiments, and co-wrote the paper. Competing interests: The authors declare that they have no competing interests.