Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

FEBS Journal

Volumn 276, Issue 15, 2009, Pages 4256-4265

  Föger, Niko ^a   Bulfone Paus, Silvia ^a   Chan, Andrew C ^b   Lee, Kyeong Hee ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b GENENTECH INC   (United States)

Author keywords

Apoptosis; CD95; Compartmentalization; FADD; Nuclear trafficking

Indexed keywords

CASPASE 8; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL MIGRATION; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

APOPTOSIS; BURKITT LYMPHOMA; CASPASE 8; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MEMBRANE; CELL NUCLEUS; CYTOPLASM; ENDOCYTOSIS; ENDOSOMES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; NEOPLASM PROTEINS; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 68149157991     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07134.x     Document Type: Article

References (28)

1. Chinnaiyan AM, O'Rourke K, Tewari M Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505 512.
2. Ashkenazi A Dixit VM (1998) Death receptors: signaling and modulation. Science 281, 1305 1308.
3. Tibbetts MD, Zheng L Lenardo MJ (2003) The death effector domain protein family: regulators of cellular homeostasis. Nat Immun 4, 404 409.
4. Chinnaiyan AM, Tepper CG, Seldin MF, O'Rourke K, Kischkel FC, Hellbardt S, Krammer PH, Peter ME Dixit VM (1996) FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 271, 4961 4965.
5. Zhang J, Cado D, Chen A, Kabra NH Winoto A (1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296 300.
6. Newton K, Harris AW, Bath ML, Smith KG Strasser A (1998) A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 17, 706 718.
7. Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM Hedrick SM (1998) A role for FADD in T cell activation and development. Immunity 8, 439 449.
8. Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, Peter ME Chan AC (2006) The role of receptor internalization in CD95 signaling. EMBO J 25, 1009 1023.
9. Gómez-Angelats M Cidlowski J (2003) Molecular evidence for the nuclear localization of FADD. Cell Death Differ 10, 791 797.
10. Screaton RA, Kiessling S, Sansom OJ, Millar CB, Maddison K, Bird A, Clarke AR Frisch SM (2003) Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci USA 100, 5211 5216.
11. Bhojani MS, Chen G, Ross BD, Beer DG Rehemtulla A (2005) Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. Cell Cycle 4, 1478 1481.
12. Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, Griffin LB, Yu J, Coppola JM, Giordano TJ et al. (2005) Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc Natl Acad Sci USA 102, 12507 12512.
13. Stolz LE, Huynh CV, Thorner J York JD (1998) Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. Genetics 148, 1715 1729.
14. Itoh T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S Takenawa T (2001) Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science 291, 1047 1051.
15. Itoh T Takenawa T (2004) Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins. Curr Top Microbiol Immunol 282, 31 47.
16. Jost M, Simpson F, Kavran JM, Lemmon MA Schmid SL (1998) Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr Biol 8, 1399 1402.
17. Algeciras-Schimnich A Peter ME (2003) Actin dependent CD95 internalization is specific for type I cells. FEBS Lett 546, 185 188.
18. Boldin MP, Goncharov TM, Goltsev YV Wallach D (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85, 803 815.
19. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH Peter ME (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14, 5579 5588.
20. Scaffidi C, Volkland J, Blomberg I, Hoffmann I, Krammer PH Peter ME (2000) Phosphorylation of FADD/MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. J Immunol 164, 1236 1242.
21. Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL et al. (2005) Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell 19, 321 332.
22. Alappat EC, Volkland J Peter ME (2003) Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site. J Biol Chem 278, 41585 41588.
23. Faustino RS, Cheung P, Richard MN, Dibrov E, Kneesch AL, Deniset JF, Chahine MN, Lee K, Blackwood D Pierce GN (2008) Ceramide regulation of nuclear protein import. J Lipid Res 49, 654 662.
24. Grullich C, Sullards MC, Fuks Z, Merrill AH Kolesnick R (2000) CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis. J Biol Chem 275, 8650 8656.
25. Grassme H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K, Kolesnick R Gulbins E (2001) CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 276, 20589 20596.
26. Wagenknecht B, Roth W, Gulbins E, Wolburg H Weller M (2001) C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. Cell Death Differ 8, 595 602.
27. Kabra NH, Kang C, Hsing LC, Zhang J Winoto A (2001) T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc Natl Acad Sci USA 98, 6307 6312.
28. Bender LM, Morgan MJ, Thomas LR, Liu ZG Thorburn A (2005) The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ 12, 473 481.