Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide

Medical Oncology

Volumn 27, Issue 3, 2010, Pages 785-790

  Miao, Ying ^a   Xiao, Bingxiu ^a   Jiang, Zhen ^a   Guo, Yanan ^a   Mao, Fang ^a   Zhao, Junwei ^a   Huang, Xia ^a   Guo, Junming ^a  

^a NINGBO UNIVERSITY   (China)

Author keywords

Anticancer effects; Cell cycle; Gastric cancer; Lycium barbarum polysaccharide; Natural compound

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLINE; LYCIUM BARBARUM EXTRACT; POLYSACCHARIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG EFFECT; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYCIUM; NEOPLASM PROTEINS; PHYTOTHERAPY; S PHASE; STOMACH NEOPLASMS;

EID: 77956896284     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-009-9286-9     Document Type: Article

References (20)

1. YF Xin, et al. 2007 Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity Phytother Res 21 1020 1024 10.1002/ptr.2186 1:CAS:528:DC%2BD1cXlslCmug%3D%3D 17622973 (Pubitemid 350190294)
2. JC Chao SW Chiang CC Wang YH Tsai MS Wu 2006 Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells World J Gastroenterol 12 4478 4484 16874858
3. H Gong P Shen L Jin C Xing F Tang 2005 Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice Cancer Biother Radiopharm 20 155 162 10.1089/cbr.2005.20. 155 1:CAS:528:DC%2BD2MXjsl2lsb8%3D 15869449 (Pubitemid 40696097)
4. L Gan S Hua Zhang X Liang Yang H Bi Xu 2004 Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum Int Immunopharmacol 4 563 569 10.1016/j.intimp.2004.01.023 1:CAS:528: DC%2BD2cXjtFOit7c%3D 15099534 (Pubitemid 38501664)
5. YK Tan JW Fielding 2006 Early diagnosis of early gastric cancer Eur J Gastroenterol Hepatol 18 821 829 10.1097/00042737-200608000-00004 16825897 (Pubitemid 44034794)
6. J Guo, et al. 2007 Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin Cancer Biol Ther 6 85 88 1:CAS:528:DC%2BD2sXhtVeqsb7L 17172820
7. J Guo B Xiao Q Liu Z Gong Y Le 2008 Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells Cancer Invest 26 369 374 10.1080/07357900701788130 1:CAS:528:DC%2BD1cXlt1ahtLo%3D 18443957 (Pubitemid 351601394)
8. MS Butler 2008 Natural products to drugs: natural product-derived compounds in clinical trials Nat Prod Rep 25 475 516 10.1039/b514294f 1:CAS:528:DC%2BD1cXmtFemtrg%3D 18497896 (Pubitemid 351725315)
9. DJ Newman GM Cragg 2007 Natural products as sources of new drugs over the last 25 years J Nat Prod 70 461 477 10.1021/np068054v 1:CAS:528: DC%2BD2sXhvFKrsro%3D 17309302 (Pubitemid 46595760)
10. I Paterson EA Anderson 2005 Chemistry. The renaissance of natural products as drug candidates Science 310 451 453 10.1126/science.1116364 16239465 (Pubitemid 41507948)
11. L Gan JH Wang Q Luo SH Zhang 2001 Effect of lycium barbarum polysaccharide on apoptosis of human leukemia cells Acta Nutrimenta Sinica 23 220 224 1:CAS:528:DC%2BD3MXotVCks7g%3D
12. JL Liu LH Zhang YK Qian 1996 Immune tumor-inhibition of lycium barbarum polysaccharide on S180-bearing mice Chin J Immunol 12 115 117 1:CAS:528:DyaK28XlsVCrurs%3D
13. GD Diaz C Paraskeva MG Thomas L Binderup A Hague 2000 Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy Cancer Res 60 2304 2312 1:CAS:528:DC%2BD3cXivVakt74%3D 10786699
14. QH Hu, et al. 1994 The effect of Active components of Lycium barbarum and Garlic (LB-GO) on the synthesis of DNA and ultrastructure of U14 cervix cancer cells in mice Chin J Cancer Res 6 266 273 10.1007/BF03025580
15. M Zhang, et al. 2005 Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis Life Sci 76 2115 2124 10.1016/j.lfs.2004.11.009 1:CAS:528:DC%2BD2MXhtlGhsbo%3D 15826878 (Pubitemid 40249369)
16. N Mendoza, et al. 2003 Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from ATP site inhibitors block tumor growth Cancer Res 63 1020 1024 1:CAS:528:DC%2BD3sXhs1agt78%3D 12615717
17. ER McDonald III WS El-Deiry 2001 Checkpoint genes in cancer Ann Med 33 113 122 10.3109/07853890109002066 1:CAS:528:DC%2BD3MXks1Krurk%3D 11327114
18. QM Ding TC Ko BM Evers 1998 Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4 Am J Physiol 275 C1193 C1200 1:CAS:528:DyaK1cXns1aitLw%3D 9814966
19. S van den Heuvel E Harlow 1993 Distinct roles for cyclin-dependent kinases in cell cycle control Science 262 2050 2054 10.1126/science.8266103 8266103
20. GG McIntosh, et al. 1995 Determination of the prognostic value of cyclin D1 overexpression in breast cancer Oncogene 11 885 891 1:CAS:528: DyaK2MXosVyrurk%3D 7675447